Herbicidal oxabicyclo ethers

ABSTRACT

The present invention relates to novel oxabicyclo ether derivative compounds, compositions containing these ether derivative compounds, and methods of using these compounds or compositions to control the growth of undesired vegetation. More particularly, the present invention relates to a variety of compounds, compositions, and methods of using them which are herbicidally active on a wide variety of weed species and exhibit safety to rice, cereals or broadleaf crops.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation-in-part of copending application U.S. Ser. No. 07/431,734 field Sep. 11, 1989, now abandoned, by way of PCT application PCT/US90/04953 filed Sep. 5, 1990.

FIELD OF THE INVENTION

The present invention relates to novel oxabicyclo ether derivative compounds, to compositions containing these ether derivative compounds, and to methods of using these compounds or compositions to control the growth of undesired vegetation. More particularly, the present invention relates to a variety of compounds, compositions, and methods of using them which are herbicidally active on a wide variety of weed species and exhibit safety to rice, cereals and broadleaf crops.

BACKGROUND OF THE INVENTION

Payne et al., U.S. Pat. No. 4,567,283 and Payne et al., U.S. Pat. No. 4,670,041 disclose a variety of herbicidal bicyclic ethers of the Formula ##STR1##

U.S. Pat. No. 4,798,621 and WO 8,902,219 both disclose bicyclic ethers and their method-of-use in rice.

U.S. Pat. No. 4,486,219 discloses bicyclic ethers of the formula: ##STR2##

It is an object of the present invention to provide compounds and compositions which exhibit herbicidal activity on a variety of economically important weed species. It is a further object of the present invention to provide compounds and compositions that are herbicidally safe to rice, cereals and broadleaf crops. It is a feature of the present invention to furnish novel oxabicyclo ethers that exhibit useful herbicidal activity. These and other objects, features and advantages will become apparent with respect to the following description of the invention.

SUMMARY OF THE INVENTION

The present invention comprises compounds of the formulas selected from the group consisting of: ##STR3## and stereoisomers thereof, wherein

X and Y are independently H or C(R³)(R⁴) OR⁵ ;

Z is C(R³)(R⁴) OR⁵ ;

R¹ is H or a straight-chain C₁ -C₃ alkyl;

R² is H, C₁ -C₆ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, phenyl or C₁ -C₄ alkyl substituted by Ph, OH, CN, OR⁸, SO₂ R⁸, PhSO₂, N₃, CO₂ R⁸ or CO₂ H;

R³, R⁴, R⁹ and R¹⁰ are independently H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl or C₁ -C₃ alkyl substituted with OCH₃ or OCH₂ CH₃ ;

R⁵ is C₁ -C₃ alkyl, C₂ -C₄ alkenyl, C₃ -C₄ alkynyl, benzyl or C₁ -C₄ alkyl substituted with OR⁸, OCF₃ ;

R⁸ is C₁ -C₃ alkyl;

Q is WCH₂ or ##STR4## W is phenyl optionally substituted with 1-3 substituents selected from F, Cl, Br, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, OH, CN, C₁ -C₃ haloalkyl, C₁ --C₃ haloalkoxy, C₁ -C₃ alkylthio, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl, or W is a 5 or 6-membered heterocyclic ring containing 0-2 nitrogens, 0-2 oxygens or 0-2 sulfurs, each ring optionally substituted with 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃ ;

Z¹ is CH₂, NR_(a), O, S or may be taken to form a double bond with an adjacent carbon;

R_(a) is H or C₁ -C₃ alkyl;

R⁶ is H, halogen, R⁸, OR⁸, SR⁸ or CN;

R⁷ is H, F, Cl, CH₃, OCH₃, OH or OR⁸ ;

q¹ is 0, 1 or 2; and

q is 0, 1 or 2.

provided that

1) at least one of X and Y is C(R³)(R⁴)OR⁵ ;

2) R³, R⁴, R⁹ and R¹⁰ each contains no more than four carbon atoms;

3) in Formula II, if R¹ is H then X is C(R³)(R⁴)OR⁵ and Y is H;

4) the sum of q and q¹ is 0, 1 or 2; and

5) if the sum of q and q¹ is 0 then Z¹ is CH₂.

A representative exemplification of the aforementioned heterocycles includes but is not limited to pyrrole, furan, thiophene, tetrahydropyran, tetrahydrofuran, isoxazole, oxazole, pyrazole, imidazole, thiazole, pyridine and pyrazines;

Preferred compounds of the invention for either their biological activity or ease of synthesis are:

1. Compounds of Formulas I, II, III, IV, V, VI, VII, or VIII wherein:

W is phenyl optionally substituted by 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃ ; or W is tetrahydropyran, tetrahydrofuran, thiophene, isoxazole, pyridine or pyrazine, each ring optionally substituted with 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃ ;

Q is ##STR5## R_(a) is H or C₁ -C₃ alkyl; and R⁵ is other than benzyl.

2. Compounds of Preferred 1 wherein R² is H, C₁ -C₃ alkyl, C₂ -C₃ alkenyl or C₂ -C₃ alkynyl.

3. Compounds of Preferred 2 wherein

R³ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

R⁴ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

R⁵ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

R⁹ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

R¹⁰ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;

4. Compounds of Preferred 3 wherein Q is Q-1, Q-3, Q-6, Q-7 or Q-15.

5. Compounds of Preferred 4 wherein the compound is of Formula I.

6. Compounds of Preferred 4 wherein the compound is of Formula II.

7. Compounds of Preferred 4 wherein the compound is of Formula III.

8. Compounds of Preferred 4 wherein the compound is of Formula IV.

9. Compounds of Preferred 4 wherein the compound is of Formula V.

10. Compounds of Preferred 4 wherein the compound is of Formula VI.

11. The Compounds of Preferred 4 wherein the compound is of Formula VII.

12. Compounds of Preferred 4 wherein the compound is of Formula VIII.

Specifically Preferred for its biological activity and/or ease of synthesis is the compound of Preferred 5 which is:

2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-oxabicyclo[2.2.1]heptane, (2-exo, 6-exo); and the compound of Preferred 7 which is:

2-(ethoxymethyl)-5-methyl-4-(phenylmethoxy)-6-oxabicyclo[3.2.1]octane, (2-endo, 4-endo).

All may preferably be selected from the group consisting of pyrrole, furan, thiophene, tetrahydropyran, tetrahydrofuran, isoxazole, oxazole, pyrazole, imidazole, triazole, pyridine, and pyrazine.

Compounds of Formula I-VIII that have the WCH₂ O group syn with respect to the oxygen-containing bridge are usually more herbicidally active than the anti form. The present invention contemplates all of the herbicidally active forms resulting from synthesis and from deliberately created mixtures.

The compounds of the invention are prepared by treating the appropriately substituted oxabicycloalkanol (Ia-VIIIa) with a compound of the formula WCH₂ X in which X is a halogen atom or a mesyloxy, tosyloxy group or the like. This reaction is carried out, as shown in Scheme 1, in the present of a strong base, such as an alkali metal hydride, in an inert solvent, such as ethers, aromatic hydrocarbons, dimethylformamide and the like. Suitable temperatures for the reaction are preferably from 20° C. to 100° C. The product ethers are recovered and isolated by conventional techniques.

Compositions suitable for controlling the growth of undersired vegetation are also contemplated as within the scope of this invention. Such compositions comprise an effective amount of any of the compounds disclosed herein and at least one of the following: surfactant, solid, or liquid diluent.

Methods for controlling the growth of undesired vegetation are similarly considered to be within the scope of the invention. These methods comprise applying to the locus to be protected as effective amount of any of the compounds disclosed herein. Of particular importance is the method wherein the locus to be protected is rice. ##STR6##

The alkylating agents WCH₂ X are prepared in the conventional manners known to those skilled in the art from the alcohols WCH₂ OH.

The alcohols, WCH₂ OH, are generally known in the art and are most conveniently prepared through metal hydride (e.g., sodium borohydride) reduction of the corresponding bicyclic ketones which can be derived by Friedel-Crafts type cyclization of derivatives of phenylalkylcarboxylic acid, phenoxyalkylcarboxylic acids, phenylthioalkylcarboxylic acids, benzyloxyalkylcarboxylic acids, and benzylthioalkylcarboxylic acids. Details may be found in a) T. Laird in Comprehensive Organic Chemistry, D. Barton and W. D. Ollis, ed., Vol. 1, pp. 1165-1168, Pergamon Press, New York (1979); b) M. H. Palmer and N. M. Scollick, J. Chem. Soc., C., (1968), 2833; c) C. E. Dalgliesch and Mann, J. Chem. Soc., (1945), 893; d) C. D. Hurd and S. Hayao, J. Am. Chem. Soc., (1954), 76, 4299 and 5056; and e) R. Lesser, Chem. Ber., (1923), 56, 1642.

Alternatively, the compounds of Formulas I-VIII may be prepared by the coupling procedure described in Scheme 2, which is used in cases where the standard Williamson ether synthesis proves problematic. This procedure uses a Lewis acidic metal oxide wherein the metal can remove the halide ion by forming an insoluble precipitate. For example, Silver (I) oxide can be used and the silver halide is the co-produce. Alternative metal oxides that may be used are HgO, CaO, MgO. N,N-Dimethylformamide and ethereal solvents, such as diethyl ether, tetrahydrofuran, dioxane, or 1,2-dimethoxyethane are the preferred solvents. Other solvents likely to provide good yields include dipolar aprotic solvents like dimethyl sulfoxide, actone and N,N'-dimethylpropyleneures. ##STR7##

The oxabicycloalkanols (Ia-VIIIa) can be obtained generally by one or more of the following routes: directly by a) epoxidation-cyclization of unsaturated cyclic alcohols, with or without isolation of the epoxy alcohol intermediates; indirectly by b) Diels-Alder reactions of furans with dienophiles; or by c) Diels-Alder reactions of other dienes with dienophiles.

Non-limiting illustrations of the preparation of representative compounds follow.

The compounds of Formula Ia are synthesized through the sequence shown in Scheme 3. Diels-Alder adducts are formed from readily available furans and from dienophiles including acrylate esters, acrolein, acryloyl chloride, and the like (see Murai et al., J. Chem. Soc., Chem. Comm. 221 (1981); and Kotsuki et al., Bull. Chem. Soc. Jpn., 57, 3339 (1984); and Laszlo et al., Tet. Let., 25, 4387 (1984); for Diels-Alder methodology). For example, the Diels-Alder adduct (2) is prepared from furan (3) and acryloyl chloride. Treatment of (2) with alcohol and base at 0° C. to ambient temperature produces the corresponding ester. This intermediate is treated with the appropriate Grignard reagent or reducing agent (e.g, lithium aluminum hydride) as shown in Equation 3b. Optionally ,treatment with an alkyl halide or alkyl sulfonate and a base (e.g., sodium hydride) in an inert solvent, such as tetrahydrofuran or N,N-dimethylformamide at ambient temperature to 150° C. produces (4). Alcohol (4a) or ether (4b) is oxidized with a peroxide, such as hydrogen peroxide or m-chloroperbenzoic acid, in a suitable solvent, such as methylene chloride, to yield an epoxide. This intermediate is treated with a reducing agent, such as lithium triethylborohdyride or lithium aluminum hydride, to reductively open the epoxide to produce alcohol Ia, using the method of Krishnamurthy et al., J. Amer. Chem. Soc., 95, 8486 (1973), as shown in Equation 3c. ##STR8##

Alternatively, compounds of Formula Ia may be synthesized through the sequence shown in Scheme 4, in which groups R³ and R⁴ may be varied independently. The Diels-Alder adducts (5) prepared from furan (3) and a vinyl carbonyl (6) are treated with the appropriate Grignard reagent or reducing agent to produce alcohol (7). Alcohol Ia can then be prepared via the routes previously described in Equations 3b and 3c or modifications thereof. ##STR9##

Compounds of Formula Ia, especially where R³ and/or R⁴ are allylic or vinylic can be prepared through the sequence shown in Scheme 5. The Diels-Alder adducts (8) are treated with a peroxide as described in Equation 3c. This intermediate is treated with the appropriate Grignard reagent such as vinyl magnesium halide or allyl magnesium halide, to produce alcohol (9). Alcohol Ia can be prepared via the routes previously described in Equations 3b and 3c, or modifications thereof. ##STR10##

Compounds of Formula Ia can also be synthesize through the sequence shown in Scheme 6. Diels-Alder adducts (10) are formed from furan (3) and a dicarbonyl dienophile, such as maleic anhydride, using the methods of Hanessian et al., Tet. Lett., 27, 5071 (1986) or Woodward et al., J. Amer. Chem. Soc., 70, 1161 (1948). Alcohol Ia can be prepared via the routes shown previously in Equations 4b and 4c or 5b and 5c or modifications thereof. ##STR11##

Compounds of Formula IIa can be prepared by the method described in Scheme 7 or modifications thereof. Cyclohexene (11) can be prepared via a Diels-Alder reaction using the methods of Alder et al., Chem. Ber., 86, 1312 (1953). Treatment of the diester with a Grignard reagent or a reducing agent yields the diol derivative. Monoalkylation, using methods described earlier, yield a mixture of ethers (12). Treatment of (12) with peroxide and acid, as taught in U.S. patent Ser. No. 4,542,244, yields alcohol IIa.

In situations where the endo form is desired, it can be obtained by oxidation of the 2-exo-IIa to the corresponding ketone, followed by reduction of the ketone with a reducing agent, such as sodium borohydride. ##STR12##

Compounds of Formula IIIa can be prepared by the method described in Scheme 8 or modifications thereof. Cyclohexene (13) can be prepared via a Diels-Alder from readily available dienophiles, such as maleic anhydride, and a diene component, such as isoprene or butadiene, using the methods of Fieser et al., J. Amer. Chem. Soc., 64, 802 (1942). Treatment of (13) with a Grignard reagent or reducing agent yields the diol derivative. Monoalkylation using methods described earlier yields ether (14). Treatment of (14) with peroxide and acid as taught in U.S. patent Ser. No. 4,542,244 yields IIIa.

In situations where the endo form is desired, it can be obtained by oxidation of the 2-exo-IIIa to the corresponding ketone, followed by reduction of the ketone with a reducing agent, such as sodium borohydride. ##STR13##

Compounds of Formula IIIa can also be prepared by the method described in Scheme 9 or modifications thereof. cyclohexene (15) can be prepared via a Diels-Alder from diene (16) and a readily available dienophile, such as methylacrylate. Treatment of (15) with a Grignard reagent of reducing agent yields the diol derivative. Monoalkylation using methods described earlier yields ether (17). Treatment of (17) with peroxide and acid, as described earlier, yields IIIa. In situations where the endo form is desired, it can be obtained by oxidation of the 2-exo-IIIa to the corresponding ketone, followed by reduction of the ketone with a reducing agent, such as sodium borohydride. ##STR14##

Compounds of Formula IV can be prepared by the method described in Scheme 10. Hydroxylation of 1,5-cyclooctadiene with a catalytic amount of osmium tetroxide and trimethylamine oxide as stoichiometric oxidant, adapted from a literature procedure [Ray et al., Tet. Lett., 21, 449 (1980)], followed by Williamson ether coupling reaction with the appropriate alkylating agent WCH₂ X, as described previously, yields ether (18). Oxidation of this alcohol using Jones reagent, as described by Heap et al. J. Chem. Soc. B, 164 (1966), yields ketone (19), which is alkylated with an appropriately substituted ketone using an amide base under conditions known in the art. Treatment of the resulting alcohol with an alkyl halide in the presence of a strong base, as described previously, yields (20). Addition of an appropriate Grignard reagent or reducing agent (such as sodium borohydride) to the carbonyl group produces alcohol (21), which is cyclized to yield the desired ether IVa by means of the alkoxymercuratin/demurcuration sequence [Bordwell et al., J. Amer. Chem. Soc., 88, 993 (1966)] . ##STR15##

Compounds of Formula VIIa (where X=H) and VIa can be prepared by the method described in Scheme 11 or modifications thereof. Diesters (22) and (23) can be prepared via a Diels-Alder reaction such as described by Ruden et a., (J. Amer. Chem. Soc., 97, 6892 (1975)) using readily available diene components, such as isoprene or butadiene and a dialkylketomalonate. Treatment of the esters with a Grignard reagent or a reducing reagent, as described earlier, yields the diols (24) and (25). Monoalkylation, using methods described earlier, followed by treatment with peroxide and acid, as described earlier, yield alcohols VIIa and VIa. In situations where the endo alcohol is desired, it can be obtained by oxidation of the exo-VIIa or exo-VIa to the corresponding ketone followed by reduction of the ketone with a reducing gent, such as sodium borohydride. ##STR16##

Compounds of Formula VIIa (where Y=H) and of Formula Va can be prepared by the method described in Scheme 12 or modifications thereof. Diene (26) can be prepared from the corresponding diene ester by addition of a Grignard reagent or a reducing agent such as described by Corey et al. (Tet. Let., 30, 2537 (1975), followed by alkylation of the resulting alcohol. Diels-Alder reaction of (26) with glyoxylate using methods similar to Jurczak et al., J. Org. Chem., 44, 3347 (1979) yields (27) and (28). Treatment of (27) and (28) with a Grignard reagent or a reducing agent yields alcohols (29) and (30). Treatment with peroxide and acid as described earlier yields alcohols VIIa and Va. The endo alcohol can be obtained as described in Scheme 11. ##STR17##

Compounds of Formula VIII can be prepared by the method described in Scheme 13. Treatment of compound (4) with a trialkylamine N-oxide and catalytic osmium tetroxide yields triol (31). Alkylation of (31) with a QX (such as benzyl bromide), followed by treatment with R⁵ X and a strong base, yields VIII. ##STR18##

EXAMPLE 1 Step A: 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 1,4-dimethyl-, methyl ester, (endo and exo, racemic)

Acryloyl chloride (32.8 ml, 0.40 mol) was cooled to 0° C. in an ice-water bath under a nitrogen atmosphere. Aluminum chloride (1.60 g, 0.012 mol) was added in 0.5 g portions with stirring. The mixture was stirred at 5° C. for 10 minutes, then was cooled to -65° C. with an isopropanol-dry ice bath. 2,5-Dimethylfuran (38.4 g, 0.40 mol) was added dropwise at -65° C. to -50° C. over 1.5 hours. After addition was complete, the mixture was stirred for 1 hour. Methylene chloride (250 ml) was added to the mixture. The mixture was then cannulated to a stirring mixture of triethylamine (48.4 g, 0.48 mol) and methanol ()60 ml) at -55° C. to -40° C. over 10 minutes. The mixture was stirred at -65° C. for 1.25 hours, then was allowed to warm to ambient temperature. The mixture was poured into 500 ml water. The phases were separated and the aqueous layer was extracted two times with methylene chloride. The combined organic layers were washed with saturated sodium bicarbonate and brine solutions, dried over magnesium sulfate and concentrated in vacuo to leave 35.12 g of a yellow oil. Flash chromatography in 3:1 hexanes:ether on 800 g of silica gel yielded 17.34 g of the endo isomer and 11.82 g of the exo isomer.

NMR (CDCl₃) endo isomer: 6.22 (d, 1H), 6.03 (d, 1H), 3.61 (s, 3H), 2.88 (dd, 1H), 1.91 (ddd, 1H), 1.80 (ddd, 1H), 1.70 (s, 3H), 1.56 (2, 3H).

NMR (CDCl₃) exo isomer: 6.18 (d, 1H), 6.12 (d, 1H), 3.69 (s, 3H), 2.52 (dd, 1H), 2.0 (dd, 1H), 1.66 (dd, 1H), 1.62 (s, 3H), 1.50 (s, 3H).

Step B: 7-oxabicyclo[2.2.1]hept-5-ene-2-methanol, 1,4-dimethyl-, exo-, (racemic-)

Lithium aluminum hydride (2.3 g, 60.0 mmol) was added under a nitrogen atmosphere to 100 ml dry tetrahydrofuran. The mixture was heated at reflux for 15 minutes, then cooled to 0° C. A solution of 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 1,4-dimethyl-, methyl ester, (exo, racemic) (14.3 g, 78.6 mmol) in 100 ml tetrahydrofuran was added dropwise over 1.5 hours. The mixture was then allowed to warm to ambient temperature and stirred for another 4.0 hours. The mixture was cooled to 5° C. in an ice-water bath and 2.3 ml of water, 2.3 ml of 10% sodium hydroxide, and 2.3 ml of water were added The solids were removed by suction filtration and washed with 40 ml of cold tetrahydrofuran. The filtrate was concentrated in vacuo to yield 9.5 g of a colorless oil.

NMR (CDCl₃): 6.22 (d, 1H), 6.12 (d, 1H), 3.83 (m, 1H), 3.74 (m, 1H), 2.17 (dd, 1H), 1.86 (m, 1H), 1.68 (dd, 1H), 1.59 (s, 3H), 1.58 (s, 3H), 1.51 (dd, 1H).

IR (CH₂ Cl₂): 3620, 3480, 1385, 1330, 1190, 1140, 1120, 1075, 1035, 975, 365 cm⁻¹.

MS (CI): 155 (M+1), 137, 109, 107, 96, 95, 93.

Step C: 7-oxabicyclo[2.2.1]hept-2-ene, 1,4-dimethyl-2-[(phenyl methoxy)methyl]-, (exo-, racemic)

Sodium hydride (1.54 g, 3.85 mmol of a 60% oil dispersion) was washed with hexanes, decanted, and suspended in 20 ml of dimethylformamide. A solution of 4.75 g (30.8 mmol) of 7-oxabicyclo[2.2.1]hept-5-ene-2-methanol, 1,4-dimethyl-, exo (racemic) in 40 ml dimethylformamide was added dropwise at 20° over 45 minutes. The mixture was stirred 45 minutes at ambient temperature. Benzyl bromide (6.05 g, 35.4 mmol) was added dropwise in 30 ml dimethylformamide over 30 minutes. The mixture was stirred 20 hours at ambient temperature. The mixture was poured into 350 ml of water and extracted three times with methylene chloride. The combined extracts were washed with brine, dried over magnesium sulfate and concentrated in vacuo to yield 7.83 g of a yellow oil. Flash chromatography in 3:1 hexanes:ether on 400 g of silica gel yielded 3.77 g of a light yellow oil.

NMR (CDCl₃): 7.40-7.26 (m, 5H), 6.12 (s, 2H), 4.51 (dq, 2H), 3.60 (dd, 1H), 3.43 (dd, 1H), 1.97 (m, 1H), 1.70 (dd, 1H), 1.56 (s, 3H), 1.53 (s, 3H), 1.18 (dd, 1H).

IR (CH₂ Cl₂): 1595, 1450, 1380, 1360, 1330, 1195, 1140, 1120, 1090, 1035, 1025, 860.

Anal. Calcd. for C₁₆ H₂₀ O₂ : C, 78.69; H, 8.20, Found: C, 78.80; H, 8.37.

Step D: 3.8-dioxatricyclo[3.2.1.0 sup2, sup4]octane, 1,5-dimethyl-6-[(phenylmethoxy)methyl]-, (exo, racemic-)

To a stirring solution of 3.60 g (15.0 mmol) of 7-oxabicyclo[2.2.1]hept-2-ene, 1,4-dimethyl-2-[(phenylmethoxy)methyl]- (exo, racemic) in 50 ml methylene chloride was added 3.56 g (16.5 mmol) of 80% technical m-chloroperbenzoic acid at 0° C. to 10° C. The mixture was stirred at 0° C. to 10° C. for 1 hour, then at ambient temperature. After 20 hours at ambient temperature, the mixture was cooled to 0° C. for 0.5 hour, filtered, and washed with cold methylene chloride. The filtrate was washed with 10% sodium sulfite, sat. sodium bicarbonate, and brine and dried over magnesium sulfate and concentrated in vacuo to yield 4.05 g of a light yellow oil. Flash chromatography in 1:1 hexane:ether on 150 g of silica gel yielded 3.30 g of a colorless liquid.

NMR (CDCl₃): 7.40-7.26 (m, 5H), 4.48 (dq, 2H), 3.52 (dd, 1H), 3.26 (dd, 1H), 3.17 (dq, 2H), 2.10-1.98 (m, 1H), 1.85 (dd, 1H), 1.47 (s, 3H), 1.46 (s, 3H), 1.18 (dd, 1H).

IR (CH₂ Cl₂): 1451, 1400, 1380, 1362, 1308, 1216, 1192, 1120, 1090, 1025, 968, 915, 880, 870, 830, 810 cm⁻¹.

MS (CI): 261 (M+1), 183, 181, 169, 153, 139, 91.

Step E: 7-oxabicyclo[2.2.1]heptan-2-ol, 1,4-dimethyl-6-[(phenylmethoxy)methyl]-, (exo, racemic), mixed with -5-[(phenylmethoxy)methyl]regioisomer

To a stirring 1M solution of lithium triethylborohydride (25.4 ml) in tetrahydrofuran was added 3.30 g (12.7 mmol) of 3,8-dioxatricyclo[3.2.1.0 sup2, sup4]octane,1,5-dimethyl-6-[(phenylmethoxy)methyl]-, (exo, racemic) in 10 ml tetrahydrofuran at ambient temperature. After 3 hours at reflux, the mixture was cooled to 0° C. and 10.2 g of a 10% sodium hydroxide solution was added dropwise. The mixture was warmed to ambient temperature and 8.64 g of 30% hydrogen peroxide (76.2 mmol) was added dropwise. The mixture was stirred at 40° C. for 30 minutes, then was saturated with potassium carbonate crystals. The mixture was poured into 100 ml ether and the organic layer was separated. The aqueous layer was extracted with ether three times. The combined organic layers were washed with brine, dried over magnesium sulfate and concentrated in vacuo to yield 4.45 g of a light yellow oil. Flash chromatography in 3:1 ether: hexanes on 150 g of silica gel yielded 2.04 g of colorless oil containing a 2:1 mixture of the 5-(phenylmethoxymethyl)isomer: 6-(phenylmethoxy) methyl isomer.

NMR (CDCl₃): 7.32 (m, 5H), 4.48 (m, 2H), 3.77 (m, 1H), 3.64 (m, 1H), 3.20 (m, 1H), 2.20 (m, 1H), 1.90 (m, 1H), 1.75 (m, 1H), 1.66 (m, 1H), 1.45, 1.43, 1.41 and 1.38 (s, 6H, total), 1.30 (m, 1H), 1.12 (m, 1H).

IR(CH₂ Cl₂): 3580, 3460 (br), 1452, 1380, 1363, 1203, 1090, 1070, 1027, 860 cm⁻¹.

Step F: 7-oxabicyclo[2.2.1]heptane, 1,4-dimethyl-2-(phenylmethoxy)-6-[(phenylmethoxy)methyl]-, 2:1 with the -5-[(phenylmethoxy)methyl]isomer, (exo, exo, racemic)

Sodium hydride (0.39 g, 9.73 mmol) was washed with hexanes, decanted, and suspended in 10 ml of dimethylacetamide. To the suspension was added 2.04 g (7.79 mmol) of 7-oxabicyclo[2.2.1]heptan-2-ol, 1,4-dimethyl-6-[(phenylmethoxy)methyl]-(exo, racemic), mixed with -5-[(phenylmethoxy)methyl]regioisomer in 20 ml dimethylacetamide at ambient temperature over 20 minutes. The mixture was stirred at 65° C. for 2 hours, then 1.66 g (9.73 mmol) of benzyl bromide in 10 ml dimethylacetamide was added at 0° C. The mixture was warmed to ambient temperature. After 20 hours, the mixture was poured into 100 ml methylene chloride and 100 ml water. The phases were separated and the aqueous layer was extracted three times with methylene chloride. The combined organic layers were washed with brine, dried, and concentrated in vacuo to yield 4.00 g of a light yellow oil. Flash chromatography in 2:1 hexanes:ether on 150 g of silica gel yielded 1.97 g of a light oil containing a 2:1 mixture of isomers.

NMR (CDCl₃): 7.32 (m, 10H), 4.58-4.36 (m, 4H), 3.54 (m, 2H), 3.20 (m, 1H), 2.02 (m, 1H), 1.88 (m, 1H), 1.8-1.6 (m, 1H), 1.47, 1.45 and 1.43 (s, 6H total), 1.2-1.05 (m, 2H).

IR (CH₂ Cl₂): 1605, 1587, 1495, 1452, 1385, 1372, 1360, 1333, 1203, 1185, 1085, 1013, 860 cm ⁻¹.

MS (CI): 363 (M+1), 335, 261, 246, 245, 244, 215, 181, 155, 137, 119, 91.

EXAMPLE 2 Step A: 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, methyl ester (exo and endo, racemic)

To a mixture of 93.0 g (1.37 mmol) of furan and 0.50 g (8.6 mmol) of propylene oxide was added 47.0 g (0.52 mmol) acryloyl chloride at ambient temperature. The mixture was stirred under a nitrogen atmosphere for tree days in the dark. The mixture was then added to a solution of 45.0 ml (0.556 mol) pyridine and 45.0 ml of methanol in 100 ml methylene chloride at 0° C. The mixture was warmed to ambient temperature after the addition was complete. After 1 hour, water was added to the mixture and the layers were separated. The aqueous layer was extracted two times with methylene chloride. The combined organic layers were washed with water, brine and dried over magnesium sulfate and concentrated in vacuo to yield 66.3 g of dark oil containing a 2:1 ratio of exo:endo isomers. Flash chromatography of 4.0 g in 20:1 hexanes:ethyl acetate on 320 g of silica gel separated the endo and exo isomers.

NMR (CDCl₃) endo: 6.44 (dd, 1), 6.21 (dd, 1H), 51.7 (dd, 1H), 5.03 (dd, 1H), 3.64 (s, 3H), 3.10 (ddd, 1H), 2.10 (ddd, 1H), 1.58 (dd, 1H).

NMR (CDCl₃) exo: 6.37 (dd, 2H), 5.10 (dd, 2H), 3.73 (s, 3H), 2.44 (dd, 1H), 2.18 (dt, 1H), 1.56 (dd, 1H).

Step B: 7-oxabicyclo[2.2.1]hept-5-ene, 2-(1-ethyl-1-methoxypropyl), exo-, (racemic-)

To 20 ml (40 mmol) of 2M ethylmagnesium bromide in tetrahydrofuran at 0° C. was added 3.0 (19.5 mmol) of 7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, methyl ester (exo, racemic) in 20 ml tetrahydrofuran. The mixture was warmed to reflux. After eight hours, the mixture was cooled to 1° and 20 ml water was added. The mixture was acidified to pH3 with 10% hydrochloric acid, then extracted two times with ether. The combined organic layers were combined, washed with brine, dried over magnesium sulfate and concentrated in vacuo to yield 2.3 g of light yellow oil. This intermediate was dissolved in 50 ml tetrahydrofuran and added to 0.65 g (45.1 mmol) of 60% sodium hydride in oil at 0 ° C. The solution was warmed to ambient temperature and stirred 10 minutes. Iodomethane (1.3 g, 40.0 mmol) was added and the mixture was refluxed. After 20 hours, the mixture was cooled and poured into 100 ml water. The layers were separated, and the aqueous layer was extracted twice with ether. The organic layers were combined and washed with brine, dried over magnesium sulfate and concentrated in vacuo to yield 1.69 g of yellow oil. Flash chromatography in 6:1 hexanes: ethylacetate yielded 1.27 of a pale yellow oil.

NMR (CDCl₃): 6.40 (dd, 1H), 6.28 (dd, 1H), 4.95 (dd, 2H), 3.19 (s, 3H), 1.77 (dd, 1H), 1.60 (m, 4H), 1.47 (dd, 1H), 1.33 (dd, 1H), 0.9 (dt, 6H) .

Step C: 7-oxabicyclo[2.2.1]heptane, 2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-, [exo-(2-alpha, 6-alpha)]

Following procedures similar to those described in Steps D, E and F in Example 1, reaction of 1.27 g (6.48 mmol) of 7-oxabicyclo[2.2.1]heptane, 2-(1-ethyl-1-methoxy-propyl)(exo, racemic) with 1.9 g (6.6 mmol) of m-chloroperbenzoic acid gave 0.75 g of a yellow oil. Consequent reaction with 10 ml (10 mmol) of lithium triethylborohydride yielded 0.9 g of a pale yellow oil. Treatment with benzyl bromide, followed by flash chromatography yielded 0.20 g of a colorless oil.

NMR (CDCl₃): 7.33 (m, 5H), 4.55 (m, 4H), 3.64 (dd, 1), 3.16 (s, 3H), 1.85-1.31 (m, 9H), 0.89 and 0.88 (t, t, 6H).

EXAMPLE 3 Step A: cis-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dimethanol, (exo)-

Furan (85.0 ml, 1.17 mol) was added to maleic anhydride (81.0 g, 0.827 mol) in 100 ml ether at ambient temperature. After 20 hours, the precipitated solid was filtered off and washed with ether to give 104 g of white crystalline solid.

Reduction of 34.0 of the Diels-Alder adduct with lithium aluminum hydride, as described previously, yielded 28.0 g oil. The NMR spectrum was the same as that reported in the literature [Das et al.,J. Med. Chem., 31, 930 (1988)].

NMR (CDCl₃): 6.40 (s, 2H), 4.70 (s, 2H), 4.00 (br, 2H), 3.80 (m, 4H), 1.95 (m, 2H).

Step B: 7-oxabicyclo[2.2.1]heptane, 2,3-bis(ethoxymethoxy)-5-hydroxy-, [2 exo-(2 alpha, 3 alpha, 5 alpha)]

Alkylation of 14.0 g (0.0897 mol) cis-7-oxabicyclo[2.2.1]-hept-5-ene-2,3-dimethanol using ethyl iodide and sodium hydride was accomplished as described previously to give 15.0 g of the bis-ether. Epoxidation using m-chloroperbenzoic acid, followed by reductive opening with lithium triethylborohydride, as described previously, yielded 4.00 g of oil.

NMR (CDCl₃): 4.49 (dd, 1H), 4.23 (s, 1H), 3.96 (brt, 1H), 3.5-3.2 (m, 8H), 2.12 (brd, 1H), 1.95 (m, 3H), 1.55 (ddt, 1H), 1.17 (t, 6H).

MS (CI): 231 (M+1), 259, 185.

Step C: 7-oxabicyclo[2.2.1]heptane, 2,3-bis(ethoxymethoxy)-5-(phenylmethoxy)-, [2 exo-(2 alpha, 3 alpha, 5 alpha)]-

Coupling of 7-oxabicyclo[2.2.1]heptane, 2.3-bis(ethoxymethoxy)-5-(phenylmethoxy)-, [2 exo-(2 alpha, 3 alpha, 5 alpha)] (0.5 g, 2.17 mmol) with benzylbromidine the presence of sodium hydride, as described earlier, yielded 0.40 g of colorless oil.

NMR (CDCl₃): 7.33 (m, 5H), 4.52 (m, 4H), 3.75 (dd, 1H), 3.5-3.2 (m, 8H), 2.0-1.7 (m, 4H), 1.21 and 1.20 (t, t, 6H).

EXAMPLE 4 Step A: (±)-4-methyl-4-cyclohexene-1,2-dicarboxylic anhydride

To 50 ml (0.50 mol) of isoprene cooled to 0° C. was added 25 g (0.26 mol) of maleic anhydride portionwise. The reaction mixture was warmed to ambient temperature and stirred for 4 hours. The excess isoprene was removed under vacuum to give 40.5 g of a white solid, m.p. 63°-65° C.

NMR (CDCl₃): 5.70 (brs, 1H), 3.45 (m, 2H), 2.50 (m, 4H), 1.81 (s, 3H).

IR (KBr):2900, 1840, 1770, 1445, 1235, 965, 920, 800.

Step B: (±)-cis-4-methyl-4-cyclohexene-1,2-dimethanol

To 300 ml of tetrahydrofuran at 0° C. was added 16.0 g (0.42 mol) lithium aluminum hydride portionwise keeping the reaction temperature between 0° C. and 5° C. A solution of 33.0 g (0.20 mol) of 4-methyl-4-cyclohexene-1,2-dicarboxylic anhydride in 100 ml of tetrahydrofuran was added dropwise over 2 hours keeping the temperature between 0° C. and 10° C. The reaction mixture was warmed to ambient temperature and stirred for 2 hours. The reaction was cooled to 0° C. and 35 ml of ethyl acetate was added dropwise, followed by dropwise addition of 35 ml isopropanol and 35 ml water. The reaction mixture was filtered through celite using acetone, dried with MgSO₄ and concentrated to 33.0 g of oil. Flash chromatography in 3:1 hexanes:ethyl acetate, followed by 1:1 hexanes:ethyl acetate and finally ethyl acetate along yielded 18.2 of oil.

NMR (CDCl₃): 5.35 (brs, 1H, 3.68 (m, 2H), 3.60 (m, 2H), 3.10 (brs, 2H), 2.05 (brs, 6H), 1.64 (s, 3H).

IR (neat): 3500-3100, 1730W, 1440, 1010.

MS (CI): 157 (M+1), 139, 121.

Step C: 2-endo, 4-exo-(±)-4-hydroxy-5-methyl-6-oxabicyclo[3.2.1]octane-2-methanol

To a suspension of 39.0 g (0.124 mol) of 55% m-chloro-perbenzoic acid in 400 ml methylene chloride at 0° C. was added 19.4 g (0.124 mol) of (±)-cis-4-methyl-1,4-cyclohexene-1,2-dimethanol in 100 ml methylene chloride over 15 minutes keeping the temperature less than 8° C. The reaction mixture was warmed to ambient temperature and stirred for 24 hours. The reaction was cooled to 0° C. and 30 ml of a saturated aqueous solution of Na₂ S₂ O₃ was added dropwise keeping the temperature less than 8° C. The reaction mixture was dried with MgSO₄, filtered and concentrated. Flash chromatography in 3:1 hexanes:ethyl acetate, 1:1 hexanes:ethyl acetate, then ethyl acetate alone yielded 6.1 g oily solid.

NMR (CDCl₃): 3.80 (brd, 2H), 3.60 (brd, 1H), 3.45 (d, 2H), 2.70 (brs, 2H), 2.42 (brs, 1H), 2.0 (m), 1.5 (m), 1.33 (s, 3H).

IR (neat): 3400-3200, 2900, 1450, 1400, 1380, 1060, 1000, 820.

MS (CI): 173 (M+1), 213, 155.

Step D: (±)-2-endo,4-exo-4-hydroxy-2-(methoxymethyl)-5-methyl-6-oxabicyclo[3.2.1]octane

To 1.45 g (0.36 mol) of hexane-washed 60% sodium hydride was added 100 ml tetrahydrofuran. The reaction was cooled to 0° C. and 6.1 g (0.035 mol) of (±)-2-endo,4-exo-4-hydroxy-5-methyl-6-oxabicyclo[3.2.1]octan-2-methanol in 70 ml tetrahydrofuran was added dropwise over 45 minutes keeping the temperature between 0° C. and 5° C. The reaction mixture was warmed to ambient temperature and 2.5 ml (0.04 mol) of methyliodide was added. An additional 1.0 g (0.025 mol) of 60% sodium hydride and 2.0 ml (0.03 mol) of methyliodide was added to the reaction. After 48 hours, the reaction was cooled to 0° C. and 25 ml of water was added dropwise. The reaction mixture was extracted with ether, and then with methylene chloride. The combined organic layers were dried with MgSO₄, filtered and concentrated to 7.26 g oil. Flash chromatography in 3:1 hexanes:ethyl acetate yielded 2.0 g of oil.

NMR (CDCl₃): 3.80 (m, 2H), 3.60 (brs, 1H), 3.32 (s, 3H), 3.20 (m, 2H), 2.40 (brs, 1H), 2.18 M, 1H), 2.10 (d, 1H), 1.50 (m, 3H), 1.33 (s, 3H).

MS (CI): 187 (M+1), 204, 169, 155.

Step E: (±)-2-endo-2-(methoxymethyl)-5-methyl-6-oxabicyclo[3.2.1]octan-4-one

To 21.0 ml (0.042 mol) of 2M oxalylchloride in methylene chloride at -78° C. was added 4.2 ml (0.06 mol) dimethyl sulfoxide. The reaction mixture was stirred for 15 minutes, then 3.9 g (0.021 mol) of (±)-2-endo,4-exo-4-hydroxy-2-(methoxymethyl)-5-methyl-6-oxabicyclo[3.2.1]octane in 10 ml methylene chloride was added dropwise an the reaction mixture was stirred for 45 minutes. Triethylamine (16.5 ml, 0.12 mol) was added dropwise and the reaction mixture was warmed to ambient temperature. Water was added (50 ml) and the reaction mixture was extracted with methylene chloride, dried over MgSO₄, filtered and concentrated. Flash chromatography in 3:1 hexanes:ethyl acetate yielded 0.96 g of oil.

NMR (CDCl₃): 4.10 (m, 2H), 3.34 (m, 5H), 2.69 (brs, 1H), 2.5-2.0 (m, 4H), 1.80 (d, 1H), 1.34 (s, 3H).

IR (neat): 2920, 1720s, 1445, 1105, 975.

MS (CI): 185 (M+1), 202, 199, 216.

Step F: (±)-2-endo,4-endo-4-hydroxy-2-(methoxymethyl)-5-methyl-6-oxabicyclo[3.2.1]octane

To 2.2 g (0.012 mol) of (±)-2-endo,4-endo-4-hydroxy-2-(methoxymethyl)-5-methyl-6-oxabicyclo[3.2.1]octan4-one in tetrahydrofuran at -78° C. was added a slight excess of 1 M lithium triethylborohydride in tetrahydrofuran. After 5 minutes 10 ml of water was added and the reaction mixture was warmed to ambient temperature. The reaction mixture was extracted with methylene chloride, dried over MgSO₄, filtered and concentrated. Flash chromatography in 1:1 hexanes:ethyl acetate yielded 1.2 g of oil.

NMR (CDCl₃): 3.83 (brd, 2H), 3.40 (m, 1H), 3.32 (s, 3H), 3.20 (d, 2H), 2.40 (brs, 1H), 2.05-1.9 (m), 1.52 (d, 1H), 1.34 (s, 3H).

Step G: 2-endo,4-endo-2-(methoxymethyl)-5-methyl-4-(phenylmethoxy)-6-oxabicyclo[3.2.1]octane

To 0.12 g (3 mmol) of hexane-washed sodium hydride in tetrahydrofuran was added 0.35 g (1.8 mmol) of (±)-2-endo,4-endo-2-(methoxymethyl)-5-methyl-6-oxabicyclo[3.2.1]octan-4-ol in tetrahydrofuran. The reaction mixture was stirred at 60° C. for 24 hours. Water was added and the reaction mixture was extracted with ether, dried over MgSO₄, filtered and concentrated. Flash chromatography in 20:1 hexanes:ethyl acetate yielded an oil.

NMR (CDCl₃): 7.32 (m, 5H), 4.62 (d, 1H), 3.82 (d+dd, 2H), 3.32 (s, 3H), 3.2-2.2 (m, 3H), 2.39 (brs, 1H), 2.03 (dt, 1H), 1.8 (m, 2H), 1.49 d, 1H), 1.37 (s, 3H), 1.25 (m, 1H).

IR (neat): 2900, 1460, 1360, 1080, 1000, 960, 850, 730, 690.

MS (CI): 277 (M+1), 294.

EXAMPLE 5 Step A: (±)-diethyl 3,6-dihydro-4-methyl-2H-pyran-2,2-dicarboxylate

To 50 g (0.70 mol) isoprene was added 25 g (0.14 mol) diethylketomalonate and 0.78 g (2.4 mmol) zinc iodide. The reaction mixture was stirred at room temperature for 48 hours. The excess isoprene was removed under vacuum. Flash chromatography in 20:1 hexanes:ethyl acetate yielded 1.2 g of oil.

NMR (CDCl₃): 5.40 (brs, 1H), 4.34 (m, 2H), 4.28 (q, 4H), 2.58 (brs, 2H), 1.75 (brs, 3H), 1.29 (t, 6H.

MS (CI): 243 (M+1), 283, 225, 169.

Step B: (±)-3,6-dihydro-4-methyl-2H-pyran-2,2-dimethanol

To 200 ml tetrahydrofuran at 0° C. was added 4.0 g (0.015 mol) lithium aluminum hydride portionwise. A solution of 12.5 g (0.052 mol) of (±)-diethyl 3,6-dihydro-4-methyl-2H-pyran-2,2-dicarboxylate in 60 ml tetrahydrofuran was added dropwise over 30 minutes. The reaction mixture was warmed to ambient temperature. After 2 hours, the reaction was cooled to 0° C. and successively treated with 30 ml ethyl acetate, 30 ml isopropanol, 30 ml water dropwise keeping the temperature under 10° C. The reaction mixture was filtered through celite with acetone, dried over MgSO₄, filtered, and concentrated to an oil. Flash chromatography in 1:1 hexanes:ethyl acetate followed by ethyl acetate alone yielded 5.5 g oil.

NMR (CDCl₃); 5.42 (brs, 1H), 4.18 (brs, 2H), 3.71 (d, 2H), 3.65 (d, 2H), 1.84 (brs, 2H), 1.7 (s, 3H).

IR (neat): 3300 broad, 2900, 1435, 1380, 1110, 1020.

MS (CI): 159 (M+1), 173, 141, 127.

Step C: (±)-exo-4-hydroxy-5-methyl-2,6-dioxabicyclo[3.2.1]octan-1-methanol

To a suspension of 11.0 g (0.035 mol) 55% m-chloroperbenzoic acid in 100 ml methylene chloride at 0° C., was added 5.5 g (0.035 mol) of (±)-3,6-dihydro-4-methyl-2H-pyran-2,2-dimethanol in 100 ml methylene chloride. The reaction mixture was warmed to ambient temperature. After 20 hours, the reaction mixture was cooled to 0° C. and 30 ml of a saturated aqueous solution of Na₂ S₂ O₃ was added dropwise. The reaction mixture was dried over MgSO₄, filtered, and concentrated. Flash chromatography in 1:1 hexanes:ethyl acetate followed by ethyl acetate yielded 1.7 of oil.

NMR (CDCl₃): 4.13 (dd, 1H), 4.08 (d, 1H), 3.86 (m, 2H), 3.78 (d, 1H), 3.62 (d, 1H), 3.45 (d, 1H), 2.22 (d, 1H), 1.40 (d, 1H), 1.40 (s, 3H).

MS (CI): 175 (M+1), 192, 157.

Step D: (±)-4-exo-1-(ethoxymethyl)-4-hydroxy-5-methyl-2,6-dioxabicyclo[3.2.1]octane

To 0.3 g (0.007 mol) of 60% sodium hydride in tetrahydrofuran was added 1.2 g (0.007 mol) of (±)-exo-4-hydroxy-5-methyl-2,6-dioxabicyclo[3.2.1]octan-1-methanol in tetrahydrofuran followed by 0.6 ml (0.013 mol) ethyliodide. After 24 hours at ambient temperature, water was added and the reaction mixture was extracted with methylene chloride, dried over MgSO₄, filtered, and concentrated. Flash chromatography yielded an oil.

NMR (CDCl₃): 4.18 (dd, 1H), 4.09 (dd, 1H), 3.95 (d, 1H), 2.81 (m, 2H), 3.65-3.4 (m, 4H), 2.20 (d, 1H), 1.50 (d, 1H), 1.40 (s, 3H), 1.19 (t, 3H).

MS (CI): 203 (M+1), 220, 185.

Step E: (±)-1-(ethoxymethyl)-5-methyl-2,6-dioxabicyclo[3.2.1]octan-4-one

To 4 ml (0.008 mol) of 2 M oxalylchloride in methylene chloride at -78° C. was added successively 0.7 ml (0.01 mol) dimethylsulfoxide, 1.2 g (0.0058 mol) of (±)-4-exo-1-(ethoxymethyl)-4-hydroxy-5-methyl-2,6-dioxabicyclo[3.2.1]octane and 2.79 ml (0.02 mol) triethylamine. The reaction mixture was warmed to ambient temperature, and water was added. The reaction mixture was extracted with methyl chloride, dried over MgSO₄, filtered and concentrated. Flash chromatography yielded 1.0 g oil.

NMR (CDCl₃): 4.50 (d, 1H), 4.21 (m, 3H), 3.57 (m, 4H), 2.20 (d, 1H), 2.10 (d, 1H), 1.40 (s, 3H), 1.21 (t, 3H).

Step F: (±)-4-endo-1-(ethoxymethyl)-5-methyl-5-methyl-4-(phenylmethoxy)-2,6-dioxabicyclo[3.2.1]octane

To a slight excess of lithium triethylborohydride in tetrahydrofuran at -78° C. was added 1.0 g (0.0049 mol) of (±)-1-(ethoxymethyl)-5-methyl-2,6-dioxabicyclo[3.2.1]octan-4-one. After 5 minutes water was added and the reaction mixture was warmed to ambient temperature. The reaction mixture was extracted with methylene chloride, dried over MgSO₄, filtered, and concentrated to give 0.5 g of oil. To 0.2 g (0.97 mmol) of this oil was added 0.1 g (2.5 mmol) of 60% sodium hydride and 0.25 g (1.5 mmol) of benzylbromide in tetrahydrofuran. After 24 hours at 60° C., water was added and the reaction mixture as extracted with ether, dried over MgSO₄, filtered, and concentrated. Flash chromatography in 20:1 hexanes:ethyl acetate yielded 0.38 g oil.

NMR (CDCl₃): 7.32 (brs, 5H), 4.55 (s, 2H), 4.00 (d+d dd, 3H), 3.68 (t, 1H), 3.40 (m, 4H), 3.38 (dd, 1H), 1.79 (dd, 2H), 1.40 (s, 3H), 1.18 (s, 3H).

EXAMPLE 6 Step A: (±)-exo,exo,exo-αα-diethyl-5,6-bishydroxy-7-oxabicyclo[2.2.1]heptane-2-methanol

To 26.5 g (0.146 mol) of 2-(1-ethyl-1-hydroxypropyl)-7-oxabicyclo[2.2.1]hept-5-ene in 100 ml acetone at 0° C. was added 17.6 g (0.15 mol) N-methyl morpholine N-oxide and 10 ml of 4% osmium tetroxide in water. The reaction mixture as warmed to ambient temperature and stirred for 4 days. A saturated aqueous solution of Na₂ S₂ O₃ was added. The reaction mixture was extracted with ethyl acetate twice and the combined extracts were washed with water and brine, and dried over MgSO₄, filtered, and concentrated. Flash chromatography yielded 12.0 g thick oil.

NMR (CDCl₃): 4.44 (s, 1H), 4.38 (d, 1H), 3.85 (m), 1.8-1.7 (m), 0.84 (t+t, 6H).

MS (CI): 217 (M+1), 234.

Step B: (±)-exo,exo,exo-α,α-diethyl-6-[(2-fluorophenyl)methoxy]-5-hydroxy-7-oxabicyclo[2.2.1]heptane-2-methanol

To 1.2 g (0.03 mol) of 60% sodium hydride in tetrahydrofuran at 0° C. was added 6.0 g (0.028 mol) of (±)-exo,exo,exo-diethyl-5,6-bishydroxy-7-oxabicyclo[2.2.1]heptan-2-methanol in tetrahydrofuran. The reaction mixture was warmed to ambient temperature and 3.4 ml (0.03 mol) of 2-fluorobenzylbromide was added. After 24 hours, water was added and the reaction mixture was extracted with ether, dried over MgSO_(r), filtered and concentrated. Flash chromatography yielded 1.3 g oil.

NMR (CDCl₃): 7.5-7.0 (m, 4H), 4.69 (d+d, 2H), 4.50 (s, 1H), 4.40 (d, 1H), 3.92 (dd, 1H), 3.61 (d, 1H), 3.20 (d, 1H), 1.2-2.0 (m), 0.80 (m).

MS (CI): 324 (M+), 342.

Step C: (±)-exo-exo-exo-5-(1-ethyl-1-methoxypropyl)-3((2-fluorophenyl)methoxy-2-methoxy-7-oxabicyclo[2.2.1]heptane

To 1.3 g (4.0 mmol) of (±)-exo,exo,exo-α,α-diethyl-6-[(2-fluorophenyl)methoxy]-5-hydroxy-7-oxabicyclo[ 2.2.1]hexane-2-methanol in dimethylformamide was added excess sodium hydride and methyliodide. The reaction mixture was stirred at 70° C. for 12 hours. Following aqueous workup, flash chromatography yielded 0.25 g oil.

NMR (CDCl₃): 7.6-7.0 (m, 4H), 4.71 (brs, 2H), 4.45 (s+d, 2H), 3.66 (d, 1H), 3.52 (d, 1H), 3.52 (d, 1H), 3.42 (s, 3H), 3.15 (s, 3H), 1.8-1.2 (m), 0.80 (m, 6H).

MS (CI): 353 (M+1), 370, 338.

Tables 1-5 present examples of species of the present invention. It is understood that these enumerated examples are merely representative of the range of species contemplated by the present invention. The notation "Ph" connotes a phenyl group. Compounds in Tables 10-15 have the WCH₂ O group syn with respect to the oxygen-containing bridge. The endo-exo notation refers to the configuration of the C(R³)(R⁴)OR⁵ group. The indicated ratios (Table 10) refer to cases where the compounds of invention (I) are formed in an inseparable mixture with compounds of Formula (18). The ratio is given in the form (I:(18)). ##STR19##

The species of Tables 1-8 correspond to the Formulas I-VIII of the compounds of the present invention. Thus, the first compound identified in Table 1 (with R¹ =H; R² =H; R³ =CH₃ CH₂ ; R⁴ =CH₃ CH₂ ; R⁵ =CH₃ ; and W=2-FPh) is a species of the compound identified as Formula I.

                                      TABLE 1                                      __________________________________________________________________________      ##STR20##                                                   I                 X and Y are C(R.sup.3)(R.sup.4)OR.sup.5 (unless specified)                     R.sup.1 = R.sup.2 = H (unless specified)                                       __________________________________________________________________________     R.sup.3       R.sup.4      R.sup.5     Q                 Y                     __________________________________________________________________________     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,3-F.sub.2 Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,4-F.sub.2 Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,5-F.sub.2 Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,6-F.sub.2 Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,4-Cl.sub.2 Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,4-Br.sub.2 Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,6-Br.sub.2 Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,3-(CH.sub.3).sub.2                                                                   Hh)                   CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,4-(CH.sub.3).sub.2                                                                   Hh)                   CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,5-(CH.sub.3).sub.2                                                                   Hh)                   CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,6-(CH.sub.3).sub.2                                                                   Hh)                   CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(CH.sub.3 CH.sub.2)Ph)                                                               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(CH.sub.3 CH.sub.2)Ph)                                                               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(OH)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(CH.sub.2 CHCH)Ph)                                                                   H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(CH.sub.2 CHCH)Ph)                                                                   H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(HCC)Ph)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (4-(HCC)Ph)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-furanyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(3-Cl)pyridyl)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-(2-Cl)pyridyl)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(3-Br)thiophenyl)                                                                    H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-(2-Br)thiophenyl)                                                                    H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(5-CH.sub.3)furanyl)                                                                 H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (3-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-thiazolyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-imidazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-pyrazoyl)                                                                            H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-oxazolyl)                                                                            H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-pyrrolyl)                                                                            H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-pyrimidinyl)                                                                         H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-tetrahydropyranyl)                                                                   H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-tetrahydrofuranyl)                                                                   H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-1               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-2               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-3               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-4               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-5               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-6               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-7               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-8               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-9               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-10              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-11              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-12              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-13              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-14              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-15              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          Q-1               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          Q-3               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          Q-6               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          Q-7               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2                                                                          Q-15              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 Q-1               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 Q-3               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 Q-6               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 Q-7               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.3 CH.sub.2 CH.sub.2                                                                 Q-15              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub. 2 (2-(SCH.sub.3)Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        Q-1               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        Q-3               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        Q-6               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        Q-7               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CHCH.sub.2                                                                        Q-15              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 C CH                                                                              CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub. 2                                                                          CH.sub.2 CCH                                                                               CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               Q-1               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub. 2 CCH                                                                              Q-3               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               Q-6               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               Q-7               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 CCH                                                                               Q-15              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph Q-1               H                     CH.sub.3 CH.sub.2                                                                            CH.sub. 3 CH.sub.2                                                                          CH.sub.2 Ph Q-3               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph Q-6               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph Q-7               H                     CH.sub.3 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 Ph Q-15              H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-FPh)  H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-ClPh) H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-BrPh) H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (Ph)     H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         Q-1               H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         Q-3               H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub. 2                                                                          CH.sub.2 OCH.sub.3                                                                         Q-6               H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         Q-7               H                     CH.sub.2 CH.sub.2                                                                            CH.sub.3 CH.sub.2                                                                           CH.sub.2 OCH.sub.3                                                                         Q-15              H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub. 3   CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub. 2 CH.sub.2                                                                 CH.sub.3    Q-1               H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    Q-3               H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    Q-6               H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    Q-7               H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3    Q-15              H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2 CH.sub.2                                                                   CH.sub.3 CH.sub.2 CH.sub.2                                                                  CH.sub.2 Ph CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-BrPh) H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-(OCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-(CN)Ph)                                                                              H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-(SCH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2,6-(F).sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-furanyl)                                                                             H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-tetrahydrofuran)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-thiophenyl)                                                                          H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-isoxazolyl)                                                                          H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (2-pyrazinyl)                                                                           H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    Q-1               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    Q-3               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    Q-6               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    Q-7               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3    Q-15              H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                         CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph)     H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-1               H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-3               H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-6               H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-7               H                     CH.sub.3      CH.sub.3 CH.sub.2                                                                           CH.sub.3    Q-15              H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    Q-1               H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    Q-3               H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    Q-6               H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    Q-7               H                     CH.sub.2 CHCH.sub.2                                                                          CH.sub.2 CHCH.sub.2                                                                         CH.sub.3    Q-15              H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2-FPh)  H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2-ClPh) H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    CH.sub.2 (Ph)     H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    Q-1               H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    Q-3               H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    Q-6               H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    Q-7               H                     CHCH.sub.2    CHCH.sub.2   CH.sub.3    Q-15              H                     CH.sub.2 C CH CH.sub.2 CCH CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.2 C CH CH.sub.2 CCH CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    Q-1               H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    Q-3               H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    Q-6               H                     CH.sub.2 CCH  CH.sub.2 CCH CH.sub.3    Q-7               H                     CH.sub.2 CCH  CH.sub.2 C CH                                                                               CH.sub.3    Q-15              H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    Q-1               H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    Q-3               H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    Q-6               H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    Q-7               H                     CH.sub.2 OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                          CH.sub.3    Q-15              H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    Q-1               H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    Q-3               H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    Q-6               H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    Q-7               H                     CH.sub.3 CH.sub.2                                                                            H            CH.sub.3    Q-15              H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    Q-1               H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    Q-3               H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    Q-6               H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    Q-7               H                     CH.sub.2 CH.sub.2 CH.sub.3                                                                   H            CH.sub.3    Q-15              H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub. 3 CH.sub.2 CH.sub.2 CH.sub.2                                                         H            CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    Q-1               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    Q-3               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    Q-6               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    Q-7               H                     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2                                                          H            CH.sub.3    Q-15              H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2-FPh)  H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2-ClPh) H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                        H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                       H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)                                                                         H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                     H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (2-pyridyl)                                                                             H                     CH.sub.3      CH.sub.3     CH.sub.3    CH.sub.2 (Ph)     H                     CH.sub.3      CH.sub.3     CH.sub.3    Q-1               H                     CH.sub.3      CH.sub.3     CH.sub.3    Q-3               H                     CH.sub.3      CH.sub.3     CH.sub.3    Q-6               H                     CH.sub.3      CH.sub.3     CH.sub.3    Q-7               H                     CH.sub.3      CH.sub. 3    CH.sub.3    Q-15              H                     __________________________________________________________________________     R.sup.1                                                                               R.sup.2 R.sup.3  R.sup.4  R.sup.5     Q             Y                   __________________________________________________________________________     CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-ClPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-BrPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(OCH.sub.3)Ph)                                                                   H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(CN)Ph)                                                                          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)                                                                   H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(SCH.sub.3)Ph)                                                                   H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2,6-(F).sub.2                                                                      Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2,6-(Cl).sub.2                                                                     Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-pyridyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-furanyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-tetrahydrofuran)                                                                 H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                 H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-thiophenyl)                                                                      H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-isoxazolyl)                                                                      H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-pyrazinyl)                                                                       H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-1           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-6           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-7           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-15          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-ClPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-F.sub.2                                                                        Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-BrPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-pyridyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-1           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-6           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-7           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-15          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-ClPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-CF.sub.3                                                                         Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-tetrahydropyran)                                                                 H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-pyridyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-1           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-6           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-7           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-15          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.3    Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                          CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                          Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3 CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3 CH.sub.3    Q-3           H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.3    Q-3           H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CH.sub.3                                                                          CH.sub.2 (Ph) H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-FPh)                                                                             H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CH.sub.3                                                                          Q-3           H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (Ph) H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-FPh)                                                                             H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CH CH.sub.2                                                                       CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H        H        CH.sub.2 CHCH.sub.2                                                                        Q-3           H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3 CH.sub.3 CH.sub.3    Q-3           H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.2 CH.sub. 3                                                                    CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3    Q-3           H                   H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph) H                   H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3           H                   H      CCH     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph) H                   H      CCH     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   H      C CH    CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   H      CCH     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 H      CCH     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3           H                   H      Ph      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph) H                   H      Ph      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   H      Ph      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   H      Ph      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 H      Ph      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3           H                   H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph) H                   H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3           H                   H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 (2(CH.sub.3)Ph                                                                    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              (2-FPh)     CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-ClPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-BrPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(OCH.sub.3)Ph)                                                                   H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(CN)Ph)                                                                          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)                                                                   H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-(SCH.sub.3)Ph)                                                                   H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2,6-(F).sub.2                                                                      Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2,6-(Cl).sub.2                                                                     Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-pyridyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-furanyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-tetrahydrofuran)                                                                 H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-tetrahydropyran)                                                                 H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-thiophenyl)                                                                      H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-isoxazolyl)                                                                      H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (2-pyrazinyl)                                                                       H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-1           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-6           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-7           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3    Q-15          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-ClPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-F.sub.2                                                                        Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-BrPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-pyridyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-1           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-6           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-7           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.3 CH.sub.2                                                                          Q-15          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-ClPh)                                                                            H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-CF.sub.3                                                                         Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-tetrahydropyran)                                                                 H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-pyridyl)                                                                         H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-1           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-6           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-7           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH.sub.2                                                                        Q-15          H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 Ph Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 CHCH(CH.sub.3)                                                                    Q-3           H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (Ph) H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                             H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                   CH.sub.3                                                                              CH.sub.3                                                                               H        H        CH.sub.2 OCH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                 __________________________________________________________________________     R.sup.1                                                                               R.sup.2 R.sup.3   R.sup.4    R.sup.5   W             X                  __________________________________________________________________________     CH.sub.3                                                                              CH.sub.3                                                                               H         H          CH.sub.2 OCH.sub.3                                                                       Q-3           H                  CH.sub. 3                                                                             CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-3           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.2 CH.sub.3                                                                        Q-3           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub. 3  CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3   CH.sub.3  Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub. 2                                                                      Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CH.sub.3                                                                        Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.2 CHCH.sub.2                                                                      Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  Q-3           H                  H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      CHCH.sub.2                                                                             CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  H      CCH     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  H      CCH     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      CCH     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      CCH     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      CCH     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  H      Ph      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  H      Ph      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      Ph      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      Ph      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      Ph      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      CH.sub.2 OCH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.2 (2(CH.sub.3)Ph                                                                  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                (2-FPh)   CH.sub.2 (2-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub. 2 (2-FPh)                                                                            H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-ClPh)                                                                            H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-BrPh)                                                                            H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(OCH.sub.3)Ph)                                                                   H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CN)Ph)                                                                          H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CF.sub.3)Ph)                                                                    H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(OCF.sub.3)Ph)                                                                   H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(SCH.sub.3)Ph)                                                                   H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-(Cl).sub.2                                                       Ph)           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-pyridyl)                                                                         H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub. 2 CH.sub.3                                                                        CH.sub.3  CH.sub.2 (2-furanyl)                                                                         H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-tetrahydrofuran)                                                   2             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                   7             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-thiophenyl)                                                                      H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-isoxazolyl)                                                                      H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-pyrazinyl)                                                                       H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-1           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-6           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-7           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-15          H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub. 2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-ClPh)                                                                            H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-CF.sub.3                                                                         Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-tetrahydropyran)                                                   .             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-pyridyl)                                                                         H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph) H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        Q-1           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        Q-3           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        Q-6           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        Q-7           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub. 2 CH.sub.3                                                                       Q-15          H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-ClPh)                                                                            H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-CF.sub.3                                                                         Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-tetrahydropyran)                                                                 H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-pyridyl)                                                                         H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (Ph) H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      Q-1           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      Q-3           H                  H      H       CH.sub. 2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      Q-6           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      Q-7           H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.2 CHCH.sub.2                                                                      Q-15          H                  H      H       H         H          CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      H       H         H          CH.sub.3  CH.sub.2 (2-ClPh)                                                                            H                  H      H       H         H          CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       H         H          CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      H       H         H          CH.sub.3  CH.sub.2 (2-CF.sub.3                                                                         Hh)                H      H       H         H          CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                 H                  H      H       H         H          CH.sub.3  CH.sub.2 (2-pyridyl)                                                                         H                  H      H       H         H          CH.sub.3  CH.sub.2 (Ph) H                  H      H       H         H          CH.sub.3  Q-1           H                  H      H       H         H          CH.sub.3  Q-3           H                  H      H       H         H          CH.sub.3  Q-6           H                  H      H       H         H          CH.sub.3  Q-7           H                  H      H       H         H          CH.sub.3  Q-15          H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                             H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-ClPh)                                                                            H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-CF.sub.3                                                                         Hh)                H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-tetrahydropyran)                                                                 H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-pyridyl)                                                                         H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph) H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        Q-1           H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        Q-3           H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        Q-6           H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        Q-7           H                  H      H       H         H          CH.sub.2 CH.sub.3                                                                        Q-15          H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-ClPh)                                                                            H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-CF.sub.3                                                                         Hh)                H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                 H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-pyridyl)                                                                         H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  Q-1           H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  Q-3           H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  Q-6           H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  Q-7           H                  H      H       CH.sub.3  CH.sub.3   CH.sub.3  Q-15          H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-ClPh)                                                                            H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-CF.sub.3                                                                         Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                 H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-pyridyl)                                                                         H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-1           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-6           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-7           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-15          H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-ClPh)                                                                            H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-CF.sub.3                                                                         Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                 H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-pyridyl)                                                                         H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-1           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-3           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-6           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-7           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-15          H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-ClPh)                                                                            H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-CF.sub.3                                                                         Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                 H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-pyridyl)                                                                         H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-1           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-6           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-7           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-15          H                  CH.sub.3                                                                              CH.sub.3                                                                               H         H          CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               H         H          CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               H         H          CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               H         H          CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               H         H          CH.sub.3  Q-3           H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.3   CH.sub.3  Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      H         H          CH.sub.3  Q-3           H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (Ph) H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.3   CH.sub.3  Q-3                              H      CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (Ph) H                  H      CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-FPh)                                                                             H                  H      CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                    H                  H      CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,6-Cl.sub.2                                                                       Hh)                H      CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  Q-3           H                  H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  H      H       CH.sub.2 CH(CH.sub.3).sub.2                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH(CH.sub.3).sub.2                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH(CH.sub.3).sub.2                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CH.sub.2 CH(CH.sub.3).sub.2                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CH.sub.2 CH(CH.sub.3).sub.2                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  H      H       CHCH.sub.2                                                                               CHCH.sub.2 CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CHCH.sub.2                                                                               CHCH.sub.2 CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CHCH.sub.2                                                                               CHCH.sub.2 CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CHCH.sub.2                                                                               CHCH.sub.2 CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CHCH.sub.2                                                                               CHCH.sub.2 CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  H      H       CH.sub.3  CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,5-(F).sub.2                                                                      Hh)                H      H       CH.sub.3  CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (2,4-(F).sub.2                                                                      Hh)                H      H       CH.sub.3  CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (4-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (3-FPh)                                                                             H                  H      H       CH.sub.3  CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 (3-ClPh)                                                                            H                  __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR21##                                                   II                __________________________________________________________________________     R.sup.1  R.sup.2 R.sup.3 = R.sup.4                                                                      R.sup.9 = R.sup.10                                                                      R.sup.5    O               Y                 __________________________________________________________________________     H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-BrPh)                                                                              H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(OCH.sub.3)Ph)                                                                     H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CN)Ph)                                                                            H                 H        H       CH.sub. 2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CF.sub.3)Ph)                                                                      H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(OCF.sub.3)Ph)                                                                     H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(SCH.sub.3)Ph)                                                                     H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(Cl).sub.2                                                                       Hh)               H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-furanyl)                                                                           H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydrofuran)                                                                   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-thiophenyl)                                                                        H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-isoxazolyl)                                                                        H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyrazinyl)                                                                         H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                               H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-ClPh)                                                                              H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-pyridyl)                                                                           H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (Ph)   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-1             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-3             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-6             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-7             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-15            H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-FPh)                                                                               H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-ClPh)                                                                              H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H       CH.sub.2 CH.sub. 3                                                                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-pyridyl)                                                                           H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (Ph)   H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-1             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-3             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-6             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-7             H                 H        H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-15            H                 H        H       H       H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H       H       H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H       H       H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H       H       H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H       H       H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H       H       H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H       H       H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H       H       H        CH.sub.3   CH.sub.2 (Ph)   H                 H        H       H       H        CH.sub.3   Q-1             H                 H        H       H       H        CH.sub.3   Q-3             H                 H        H       H       H        CH.sub.3   Q-6             H                 H        H       H       H        CH.sub.3   Q-7             H                 H        H       H       H        CH.sub.3   Q-15            H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-3             H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 H        H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub. 3                                                                               CH.sub.3   Q-3             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       H       H        CH.sub.3   Q-1             H                 CH.sub.3 H       H       H        CH.sub.3   Q-3             H                 CH.sub.3 H       H       H        CH.sub.3   Q-6             H                 CH.sub.3 H       H       H        CH.sub.3   Q-7             H                 CH.sub.3 H       H       H        CH.sub.3   Q-15            H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub. 3                                                                               CH.sub.3   Q-3             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-1             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-3             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-6             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-7             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-15            H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       CH.sub. 3                                                                              H        CH.sub.3   CH.sub.2 (Ph)   H                 __________________________________________________________________________     R.sup.1  R.sup.2 R.sup.3 = R.sup.4                                                                      R.sup.9 = R.sup.10                                                                      R.sup.5    O               X                 __________________________________________________________________________     CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H       CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub. 3  Q-3             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.2 CH.sub.3                                                                       H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       H       H        CH.sub.3   Q-1             H                 CH.sub.3 H       H       H        CH.sub.3   Q-3             H                 CH.sub.3 H       H       H        CH.sub.3   Q-6             H                 CH.sub.3 H       H       H        CH.sub.3   Q-7             H                 CH.sub.3 H       H       H        CH.sub.3   Q-15            H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       H       H        CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub. 3  Q-3             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 CH.sub.3                                                                               CH.sub.3                                                                               CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       H       CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       H       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-1             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-3             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-6             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-7             H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   Q-15            H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H       CH.sub.3                                                                               H        CH.sub.3   CH.sub.2 (Ph)   H                 __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________      ##STR22##                                                                     X and Y are C(R.sup.3)(R.sup.4)OR.sup.5 (unless specified)                     R.sup.1  R.sup.2                                                                               R.sup.3 = R.sup.4                                                                       R.sup.9 = R.sup.10                                                                      R.sup.5    Q                                 __________________________________________________________________________                                                                  Y                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-BrPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(OCH.sub.3)Ph)                                                                     H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CN)Ph)                                                                            H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CF.sub.3)pH)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(OCF.sub.3)Ph)                                                                     H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(SCH.sub.3)Ph)                                                                     H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl).sub.2                                                                        Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-furanyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydrofuran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-thiophenyl)                                                                        H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-isoxazolyl)                                                                        H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyrazinyl)                                                                         H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (Ph)   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-1             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-3             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-6             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-7             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-15            H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (Ph)   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-1             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-3             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-6             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-7             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-15            H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      H        H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2 Ph)        H        H      H        H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      H        H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      H        H        CH.sub.3   CH.sub.2 (Ph)   H                 H        H      H        H        CH.sub.3   Q-1             H                 H        H      H        H        CH.sub.3   Q-3             H                 H        H      H        H        CH.sub.3   Q-6             H                 H        H      H        H        CH.sub.3   Q-7             H                 H        H      H        H        CH.sub.3   Q-15            H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-1             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-3             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-6             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-7             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.3 H        CH.sub.3   CH.sub.2 (Ph)   H                 H        H      CH.sub.3 H        CH.sub.3   Q-1             H                 H        H      CH.sub.3 H        CH.sub.3   Q-3             H                 H        H      CH.sub.3 H        CH.sub.3   Q-6             H                 H        H      CH.sub.3 H        CH.sub.3   Q-7             H                 H        H      CH.sub.3 H        CH.sub.3   Q-15            H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      H        H        CH.sub.3   Q-1             H                 CH.sub.3 H      H        H        CH.sub.3   Q-3             H                 CH.sub.3 H      H        H        CH.sub.3   Q-6             H                 CH.sub.3 H      H        H        CH.sub.3   Q-7             H                 CH.sub.3 H      H        H        CH.sub.3   Q-15            H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub. 3  CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-15            H                                                                              X                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-BrPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(OCH.sub.3)Ph)                                                                     H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CN)Ph)                                                                            H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CF.sub.3)pH)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(OCF.sub.3)Ph)                                                                     H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(SCH.sub.3)Ph)                                                                     H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(Cl).sub.2                                                                       Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-furanyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydrofuran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-thiophenyl)                                                                        H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-isoxazolyl)                                                                        H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyrazinyl)                                                                         H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         CH.sub.2 (Ph)   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-1             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-3             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-6             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-7             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                         Q-15            H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (Ph)   H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-1             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-3             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-6             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-7             H                 H        H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                       Q-15            H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      H        H        CH.sub. 3  CH.sub.2 (2-ClPh)                                                                              H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      H        H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2 Ph)        H        H      H        H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      H        H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      H        H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      H        H        CH.sub.3   CH.sub.2 (Ph)   H                 H        H      H        H        CH.sub.3   Q-1             H                 H        H      H        H        CH.sub.3   Q-3             H                 H        H      H        H        CH.sub.3   Q-6             H                 H        H      H        H        CH.sub.3   Q-7             H                 H        H      H        H        CH.sub.3   Q-15            H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-1             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-3             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-6             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-7             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   Q-15            H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,4-FPh)                                                                             H                 H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,5-(F).sub.2                                                                        Hh)               H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               H        H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-BrPh)                                                                              H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-BrPh)                                                                              H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(OCH.sub.3)Ph)                                                                     H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(CN)Ph)                                                                            H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(CF.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(OCF.sub.3)Ph)                                                                     H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-(SCH.sub.3)Ph)                                                                     H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2,6-(Cl).sub.2                                                                       Hh)               CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-furanyl)                                                                           H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-tetrahydrofuran)                                                                   H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-thiophenyl)                                                                        H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-isoxazolyl)                                                                        H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-pyrazinyl)                                                                         H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      H        H        CH.sub.3   Q-1             H                 CH.sub.3 H      H        H        CH.sub.3   Q-3             H                 CH.sub.3 H      H        H        CH.sub.3   Q-6             H                 CH.sub.3 H      H        H        CH.sub.3   Q-7             H                 CH.sub.3 H      H        H        CH.sub.3   Q-15            H                 CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2,4-(F).sub.2                                                                        Hh)               CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2,5-(F).sub.2                                                                        Hh)               CH.sub.3 H      H        H        CH.sub.3   CH.sub.2 (2-F,6-ClPh)                                                                          H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (Ph)   H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         Q-1             H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         Q-3             H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         Q-6             H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         Q-7             H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         Q-15            H                 CH.sub.3 H      H        H        CH.sub.2 CH.sub.3                                                                         CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub. 3                                                                               H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       CH.sub.2 (Ph)   H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       Q-1             H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       Q-3             H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       Q-6             H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       Q-7             H                 CH.sub.3 H      H        H        CH.sub.2 CHCH.sub.2                                                                       Q-15            H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub. 2 (2-ClPh)                                                                             H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   Q-1             H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   Q-3             H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   Q-6             H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   Q-7             H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   Q-15            H                 CH.sub.3 CH.sub.2                                                                       H      H        H        CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      CH.sub.3 CH.sub. 3                                                                               CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub.3 H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,4-(F).sub.2                                                                        Hh)               CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.3 H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub. 3                                                                      CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 H        CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   Q-1             H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   Q-3             H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   Q-6             H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   Q-7             H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   Q-15            H                 CH.sub.3 H      CH.sub.3 H        CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.3 H      H        CH.sub.3 CH.sub.3   Q-15            H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-(F).sub.2                                                                        Hh)               CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-1             H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-3             H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-6             H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-7             H                 CH.sub.3 H      H        CH.sub.2 CH.sub.3                                                                       CH.sub.3   Q-15            H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-FPh)                                                                               H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-ClPh)                                                                              H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-(CH.sub.3)Ph)                                                                      H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2,6-Cl.sub.2                                                                         Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-CF.sub.3                                                                           Hh)               CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-tetrahydropyran)                                                                   H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (2-pyridyl)                                                                           H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   CH.sub.2 (Ph)   H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   Q-1             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   Q-3             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   Q-6             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   Q-7             H                 CH.sub.2 CH.sub.3                                                                       H      CH.sub.3 CH.sub.3 CH.sub.3   Q-15            H                 __________________________________________________________________________

                                      TABLE 4                                      __________________________________________________________________________      ##STR23##                                                                     X = C(R.sup.3)(R.sup.4)OR.sup.5                                                R.sup.1  R.sup.2  R.sup.3  R.sup.4  R.sup.5     Q                              __________________________________________________________________________     H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-FPh)               H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-BrPh)              H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (22-(OCH.sub.3)Ph                                                     )                              H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-(CN)Ph)            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)      H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)     H        H        CH.sub. 3 CH.sub.2                                                                      CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-(SCH.sub.3)Ph)     H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2,6-(F).sub.2                                                        Ph)                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2,6-(Cl).sub.2                                                       Ph)                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-furanyl)           H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-tetrahydrofura                                                     n)                             H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-thiophenyl)        H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-isoxazolyl)        H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (2-pyrazinyl)         H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    CH.sub.2 (Ph)                  H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    Q-1                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    Q-3                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    Q-6                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    Q-7                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3    Q-15                           H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-FPh)               H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-ClPh)              H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-CF.sub.3 Ph)       H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (2-pyridyl)           H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          CH.sub.2 (Ph)                  H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          Q-1                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          Q-3                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          Q-6                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          Q-7                            H        H        CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                       CH.sub.3 CH.sub.2                                                                          Q-15                           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-FPh)               H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-ClPh)              H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-CF.sub.3 Ph)       H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-pyridyl)           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (Ph)                  H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-1                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-3                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-6                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-7                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-15                           H        H        H        H        CH.sub.3    CH.sub.2 (2-FPh)               H        H        H        H        CH.sub.3    CH.sub.2 (2-ClPh)              H        H        H        H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      H        H        H        H        CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        H        H        CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       H        H        H        H        CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        H        H        CH.sub.3    CH.sub.2 (2-pyridyl)           H        H        H        H        CH.sub.3    CH.sub.2 (Ph)                  H        H        H        H        CH.sub.3    Q-1                            H        H        H        H        CH.sub.3    Q-3                            H        H        H        H        CH.sub.3    Q-6                            H        H        H        H        CH.sub.3    Q-7                            H        H        H        H        CH.sub.3    Q-15                           H        H        CH.sub.3 CH.sub.3 CH.sub. 3   CH.sub.2 (2-FPh)               H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-ClPh)              H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-pyridyl)           H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph)                  H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-1                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-3                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-6                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-7                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-15                           CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub. 2 (2,6-Cl.sub.2                                                        Ph)                            CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-1                            CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3                            CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub. 2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-1                            CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3                            CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            CH.sub. 2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-1                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            CH.sub.3 H        CH.sub.2 CH.sub. 3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-1                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub. 3                                                                      CH.sub.3    Q-3                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           __________________________________________________________________________

                                      TABLE 5                                      __________________________________________________________________________      ##STR24##                                                                     X = C(R.sup.3)(R.sup.4)OR.sup.5                                                R.sup.1  R.sup.2  R.sup.3 R.sup.4                                                                         R.sup.9 R.sup.10                                                                        R.sup.5     Q                              __________________________________________________________________________     H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-BrPh)              H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(OCH.sub.3)Ph)     H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CN)Ph)            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CF.sub.3)Ph)      H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(OCF.sub.3)Ph)     H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(SCH.sub.3)Ph)     H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-(F).sub.2                                                        Ph)                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-(Cl).sub.2                                                       Ph)                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-furanyl)           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydrofura                                                     n)                             H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydrofura                                                     n)                             H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-thiophenyl)        H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-isoxazolyl)        H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyrazinyl)         H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  H        H        CH.sub.2 CH.sub.3                                                                       CH.sub. 2 CH.sub.3                                                                      CH.sub.3    Q-1                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-FPh)               H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-ClPh)              H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-CF.sub.3 Ph)       H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (2-pyridyl)           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          CH.sub.2 (Ph)                  H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          Q-1                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          Q-3                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          Q-6                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          Q-7                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                          Q-15                           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-FPh)               H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-ClPh)              H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-CF.sub.3 Ph)       H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub. 2 CHCH.sub.2                                                                       CH.sub.2 (2-pyridyl)           H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        CH.sub.2 (Ph)                  H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-1                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-3                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-6                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-7                            H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                        Q-15                           H        H        H        H        CH.sub.3    CH.sub.2 (2-FPh)               H        H        H        H        CH.sub.3    CH.sub.2 (2-ClPh)              H        H        H        H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      H        H        H        H        CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        H        H        CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       H        H        H        H        CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        H        H        CH.sub.3    CH.sub.2 (2-pyridyl)           H        H        H        H        CH.sub.3    CH.sub.2 (Ph)                  H        H        H        H        CH.sub.3    Q-1                            H        H        H        H        CH.sub.3    Q-3                            H        H        H        H        CH.sub.3    Q-6                            H        H        H        H        CH.sub.3    Q-7                            H        H        H        H        CH.sub.3    Q-15                           H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)               H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-ClPh)              H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-pyridyl)           H        H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph)                  H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-1                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-3                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-6                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-7                            H        H        CH.sub.3 CH.sub.3 CH.sub.3    Q-15                           CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-1                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph)                  CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    Q-1                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    Q-3                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    Q-6                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    Q-7                            CH.sub.2 CH.sub.3                                                                       H        CH.sub.3 CH.sub.3 CH.sub.3    Q-15                           CH.sub.3 H        H        H        CH.sub.3    Q-1                            CH.sub.3 H        H        H        CH.sub.3    Q-3                            CH.sub.3 H        H        H        CH.sub.3    Q-6                            CH.sub.3 H        H        H        CH.sub.3    Q-7                            CH.sub.3 H        H        H        CH.sub.3    Q-15                           CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub. 3                                                                               H        H        H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        H        H        CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    Q-1                            CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    Q-3                            CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    Q-6                            CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    Q-7                            CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    Q-15                           CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    Q-1                            CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    Q-3                            CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    Q-6                            CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    Q-7                            CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    Q-15                           CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 H        H        CH.sub.3 CH.sub.3    Q-1                            CH.sub.3 H        H        CH.sub.3 CH.sub.3    Q-3                            CH.sub.3 H        H        CH.sub.3 CH.sub.3    Q-6                            CH.sub.3 H        H        CH.sub.3 CH.sub.3    Q-7                            CH.sub.3 H        H        CH.sub.3 CH.sub.3    Q-15                           CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        H        CH.sub.3 CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-1                            CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-3                            CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-6                            CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-7                            CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    Q-15                           CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub. 2 (2-ClPh)             CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)                                                      2                              CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                       CH.sub.3    CH.sub.2 (Ph)                  CH.sub.3 H        CH.sub.3 H        CH.sub.3    Q-1                            CH.sub.3 H        CH.sub.3 H        CH.sub.3    Q-3                            CH.sub.3 H        CH.sub.3 H        CH.sub.3    Q-6                            CH.sub.3 H        CH.sub.3 H        CH.sub.3    Q-7                            CH.sub.3 H        CH.sub.3 H        CH.sub.3    Q-15                           CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2-FPh)               CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2-ClPh)              CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2-(CH.sub.3)Ph)      CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                            CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2-CF.sub.3 Ph)       CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2-tetrahydropyra                                                     n)                             CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (2-pyridyl)           CH.sub.3 H        CH.sub.3 H        CH.sub.3    CH.sub.2 (Ph)                  __________________________________________________________________________

                                      TABLE 6                                      __________________________________________________________________________      ##STR25##                                                   VI                R.sup.1     R.sup.3 = R.sup.4                                                                          R.sup.9 = R.sup.10                                                                         R.sup.5        O                           __________________________________________________________________________     H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-FPh)            H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-ClPh)           H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-BrPh)           H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(OCH.sub.3)                                                        Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(CN)Ph)         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(CF.sub.3)P                                                        h)                          H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(OCF.sub.3)                                                        Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(SCH.sub.3)                                                        Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2,6-(F).sub.2                                                         Ph)                        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2,6-(Cl).sub.                                                        2 Ph)                       H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-pyridyl)        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-furanyl)        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-tetrahydrof                                                        uran)                       H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-thiophenyl)     H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-isoxazolyl)     H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-pyrazinyl)      H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (Ph)               H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-1                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-3                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-6                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-7                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-15                        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2-FPh)            H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2-ClPh)           H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2-(CH.sub.3)P                                                        h)                          H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2-CF.sub.3                                                           Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2-tetrahydrop                                                        yran)                       H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (2-pyridyl)        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             CH.sub.2 (Ph)               H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             Q-1                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             Q-3                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             Q-6                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             Q-7                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                             Q-15                        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2-FPh)            H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2-ClPh)           H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2-(CH.sub.3)P                                                        h)                          H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2-CF.sub.3                                                           Ph)                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2-tetrahydrop                                                        yran)                       H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (2-pyridyl)        H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           CH.sub.2 (Ph)               H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           Q-1                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub. 3                                                                         CH.sub.2 CHCH.sub.2                                                                           Q-3                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           Q-6                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           Q-7                         H           CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                           Q-15                        H           H           H           CH.sub.3       CH.sub.2 (2-FPh)            H           H           H           CH.sub.3       CH.sub.2 (2-ClPh)           H           H           H           CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          H           H           H           CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         H           H           H           CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         H           H           H           CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       H           H           H           CH.sub.3       CH.sub.2 (2-pyridyl)        H           H           H           CH.sub.3       CH.sub.2 (Ph)               H           H           H           CH.sub.3       Q-1                         H           H           H           CH.sub.3       Q-3                         H           H           H           CH.sub.3       Q-6                         H           H           H           CH.sub.3       Q-7                         H           H           H           CH.sub.3       Q-15                        H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-FPh)            H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-ClPh)           H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         H           CH.sub.3    CH.sub. 3   CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-pyridyl)        H           CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (Ph)               H           CH.sub.3    CH.sub.3    CH.sub.3       Q-1                         H           CH.sub.3    CH.sub.3    CH.sub.3       Q-3                         H           CH.sub.3    CH.sub.3    CH.sub.3       Q-6                         H           CH.sub.3    CH.sub.3    CH.sub.3       Q-7                         H           CH.sub.3    CH.sub.3    CH.sub.3       Q-15                        CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-pyridyl)        CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub. 3      CH.sub.2 (Ph)               CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-1                         CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-3                         CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-6                         CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-7                         CH.sub.3    CH.sub.2 CH.sub.3                                                                          CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-15                        CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-pyridyl)        CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (Ph)               CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       Q-1                         CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       Q-3                         CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       Q-6                         CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       Q-7                         CH.sub.2 CH.sub.3                                                                          CH.sub.3    CH.sub.3    CH.sub.3       Q-15                        CH.sub.3    H           H           CH.sub.3       Q-1                         CH.sub.3    H           H           CH.sub.3       Q-3                         CH.sub.3    H           H           CH.sub.3       Q-6                         CH.sub.3    H           H           CH.sub.3       Q-7                         CH.sub.3    H           H           CH.sub.3       Q-15                        CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.3    H           H           CH.sub.3       CH.sub.2 (2-pyridyl)        CH.sub.3    H           H           CH.sub.3       CH.sub.2 (Ph)               CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       Q-1                         CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       Q-3                         CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       Q-6                         CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       Q-7                         CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       Q-15                        CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (2-pyridyl)        CH.sub.3    CH.sub.3    CH.sub.3    CH.sub.3       CH.sub.2 (Ph)               CH.sub.3    H           CH.sub.3    CH.sub.3       Q-1                         CH.sub.3    H           CH.sub.3    CH.sub.3       Q-3                         CH.sub.3    H           CH.sub.3    CH.sub.3       Q-6                         CH.sub.3    H           CH.sub.3    CH.sub.3       Q-7                         CH.sub.3    H           CH.sub.3    CH.sub.3       Q-15                        CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub. 2 (2-pyridyl)       CH.sub.3    H           CH.sub.3    CH.sub.3       CH.sub.2 (Ph)               CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-1                         CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-3                         CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-6                         CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-7                         CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       Q-15                        CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (2-pyridyl)        CH.sub.3    H           CH.sub.2 CH.sub.3                                                                          CH.sub.3       CH.sub.2 (Ph)               CH.sub.3    CH.sub.3    H           CH.sub.3       Q-1                         CH.sub.3    CH.sub.3    H           CH.sub.3       Q-3                         CH.sub.3    CH.sub.3    H           CH.sub.3       Q-6                         CH.sub.3    CH.sub.3    H           CH.sub.3       Q-7                         CH.sub.3    CH.sub.3    H           CH.sub.3       Q-15                        CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2-FPh)            CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2-ClPh)           CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2-(CH.sub.3)P                                                        h)                          CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2,6-Cl.sub.2                                                         Ph)                         CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2-CF.sub.3                                                           Ph)                         CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2-tetrahydrop                                                        yran)                       CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (2-pyridyl)        CH.sub.3    CH.sub.3    H           CH.sub.3       CH.sub.2 (Ph)               __________________________________________________________________________

                                      TABLE 7                                      __________________________________________________________________________      ##STR26##                                                                     X and Y are C(R.sup.3)(R.sup.4)OR.sup.5 (unless specified)                     __________________________________________________________________________     R.sup.1  R.sup.3 = R.sup.4                                                                       R.sup.9 = R.sup.10                                                                      R.sup.5      Q                Y                     __________________________________________________________________________     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-FPh) H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-BrPh)                                                                               H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(OCH.sub.3)Ph)                                                                      H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CN)Ph)                                                                             H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CF.sub.                                                                            H)Ph)                 H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(OCF.sub.3)Ph)                                                                      H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(SCH.sub.3)Ph)                                                                      H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-(F).sub.2 Ph)                                                                     H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-furanyl)                                                                            H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydrofuran)                                                                    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-thiophenyl)                                                                         H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-isoxazolyl)                                                                         H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyrazinyl)                                                                          H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (Ph)    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-1              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-3              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-6              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-7              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-15             H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-FPh) H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-ClPh)                                                                               H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-pyridyl)                                                                            H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           CH.sub.2 (Ph)    H                     H        CH.sub. 2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           Q-1              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           Q-3              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           Q-6              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           Q-7              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                           Q-15             H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-FPh) H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-ClPh)                                                                               H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub. 2                                                                        CH.sub.2 (2-pyridyl)                                                                            H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (Ph)    H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         Q-1              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         Q-3              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         Q-6              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         Q-7              H                     H        CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                         Q-15             H                     H        H        H        CH.sub.3     CH.sub.2 (2-FPh) H                     H        H        H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     H        H        H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        H        H        CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     H        H        H        CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     H        H        H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        H        H        CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     H        H        H        CH.sub.3     CH.sub.2 (Ph)    H                     H        H        H        CH.sub.3     Q-1              H                     H        H        H        CH.sub.3     Q-3              H                     H        H        H        CH.sub.3     Q-6              H                     H        H        H        CH.sub.3     Q-7              H                     H        H        H        CH.sub.3     Q-15             H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-FPh) H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     H        CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (Ph)    H                     H        CH.sub.3 CH.sub.3 CH.sub.3     Q-1              H                     H        CH.sub.3 CH.sub.3 CH.sub.3     Q-3              H                     H        CH.sub.3 CH.sub.3 CH.sub.3     Q-6              H                     H        CH.sub.3 CH.sub.3 CH.sub.3     Q-7              H                     H        CH.sub.3 CH.sub.3 CH.sub.3     Q-15             H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub. 2 (2-(CH.sub.3)Ph)                                                                      H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-1              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-3              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-6              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-7              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-15             H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.2 CH.sub.3                                                                       CH.sub. 2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-1              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-3              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-6              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-7              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-15             H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2-FPh) H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     H        CH.sub.3 H        CH.sub.3     CH.sub.2 (Ph)    H                     H        CH.sub.3 H        CH.sub.3     Q-1              H                     H        CH.sub.3 H        CH.sub.3     Q-3              H                     H        CH.sub.3 H        CH.sub.3     Q-6              H                     H        CH.sub.3 H        CH.sub.3     Q-7              H                     H        CH.sub.3 H        CH.sub.3     Q-15             H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-1              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-3              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-6              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-7              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-15             H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 H        H        CH.sub.3     Q-1              H                     CH.sub.3 H        H        CH.sub.3     Q-3              H                     CH.sub.3 H        H        CH.sub.3     Q-6              H                     CH.sub.3 H        H        CH.sub.3     Q-7              H                     CH.sub.3 H        H        CH.sub.3     Q-15             H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-1              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-3              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-6              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-7              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-15             H                     __________________________________________________________________________     R.sup.1  R.sup.3 = R.sup.4                                                                       R.sup.9 = R.sup.10                                                                      R.sup.5      Q                X                     __________________________________________________________________________     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-FPh  H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-BrPh)                                                                               H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(OCH.sub.3)Ph)                                                                      H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(CN)Ph)                                                                             H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(CF.sub.3)Ph)                                                                       H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(OCF.sub.3)Ph)                                                                      H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-(SCH.sub.3)Ph)                                                                      H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2,6-(F).sub.2 Ph)                                                                     H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                    H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-furanyl)                                                                            H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-tetrahydrofuran)                                                                    H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-thiophenyl)                                                                         H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-isoxazolyl)                                                                         H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (2-pyrazinyl)                                                                          H                     CH.sub.3 H        H        CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 H        H        CH.sub.3     Q-1              H                     CH.sub.3 H        H        CH.sub.3     Q-3              H                     CH.sub.3 H        H        CH.sub.3     Q-6              H                     CH.sub.3 H        H        CH.sub.3     Q-7              H                     CH.sub.3 H        H        CH.sub.3     Q-15             H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-FPh) H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           CH.sub.2 (Ph)    H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           Q-1              H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           Q-3              H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           Q-6              H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           Q-7              H                     CH.sub.3 H        H        CH.sub.2 CH.sub.3                                                                           Q-15             H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-FPh) H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         CH.sub.2 (Ph)    H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         Q-1              H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         Q-3              H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         Q-6              H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         Q-7              H                     CH.sub.3 H        H        CH.sub.2 CHCH.sub.2                                                                         Q-15             H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub. 3    CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     Q-1              H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     Q-3              H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     Q-6              H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     Q-7              H                     CH.sub.3 CH.sub.2                                                                       H        H        CH.sub.3     Q-15             H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-1              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-3              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-6              H                     CH.sub. 3                                                                               CH.sub.3 CH.sub.3 CH.sub.3     Q-7              H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     Q-15             H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2,6-(F).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2,4-(F).sub.2 Ph)                                                                     H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-1              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-3              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub. 3                                                                      CH.sub.3     Q-6              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-7              H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-15             H                     CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-(F).sub.2 Ph)                                                                     H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-1              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-3              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-6              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-7              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-15             H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 CH.sub.3 H        CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 CH.sub.3 H        CH.sub.3     Q-1              H                     CH.sub.3 CH.sub.3 H        CH.sub.3     Q-3              H                     CH.sub.3 CH.sub.3 H        CH.sub.3     Q-6              H                     CH.sub.3 CH.sub.3 H        CH.sub.3     Q-7              H                     CH.sub.3 CH.sub.3 H        CH.sub.3     Q-15             H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        CH.sub.3 CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-1              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-3              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-6              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-7              H                     CH.sub.3 H        CH.sub.3 CH.sub.3     Q-15             H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-1              H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-3              H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-6              H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-7              H                     CH.sub.3 H        CH.sub.2 CH.sub.3                                                                       CH.sub.3     Q-15             H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-FPh) H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     CH.sub.2 (Ph)    H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     Q-1              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     Q-3              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     Q-6              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     Q-7              H                     CH.sub.2 CH.sub.3                                                                       CH.sub.3 CH.sub.3 CH.sub.3     Q-15             H                     H        H        H        CH.sub.3     CH.sub.2 (2-FPh) H                     H        H        H        CH.sub.3     CH.sub.2 (2-ClPh)                                                                               H                     H        H        H        CH.sub.3     CH.sub.2 (2-(CH.sub.3)Ph)                                                                       H                     H        H        H        CH.sub.3     CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                      H                     H        H        H        CH.sub.3     CH.sub.2 (2-CF.sub.3 Ph)                                                                        H                     H        H        H        CH.sub.3     CH.sub.2 (2-tetrahydropyran)                                                                    H                     H        H        H        CH.sub.3     CH.sub.2 (2-pyridyl)                                                                            H                     H        H        H        CH.sub.3     CH.sub.2 (Ph)    H                     H        H        H        CH.sub.3     Q-1              H                     H        H        H        CH.sub.3     Q-3              H                     H        H        H        CH.sub.3     Q-6              H                     H        H        H        CH.sub.3     Q-7              H                     H        H        H        CH.sub.3     Q-15             H                     __________________________________________________________________________

                                      TABLE 8                                      __________________________________________________________________________      ##STR27##                                                  VIII               R.sup.1 R.sup.2                                                                               R.sup.3                                                                               R.sup.4 R.sup.5   O              R.sup.8                 __________________________________________________________________________     H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-ClPh)                                                                             CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-BrPh)                                                                             CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(OCH.sub.3)Ph)                                                                    CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(CN)Ph)                                                                           CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-CF.sub.3)Ph)                                                                      CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(OCF.sub.3)Ph)                                                                    CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(SCH.sub.3)Ph)                                                                    CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                                   CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                                  CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-furanyl)                                                                          CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-tetrahydrofuran)                                                                  CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-thiophenyl)                                                                       CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-isoxazolyl)                                                                       CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-pyrazinyl)                                                                        CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-1            CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-3            CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-6            CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-7            CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-15           CH.sub.3                H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                              CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-ClPh)                                                                             CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-CF.sub.3                                                                          CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-pyridyl)                                                                          CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph)  CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        Q-1            CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        Q-3            CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        Q-6            CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        Q-7            CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                        Q-15           CH.sub.2 CH.sub.3       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-FPh)                                                                              CH.sub.2 CHCH.sub.2                                                            N                       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub. 2                                                                     CH.sub.2 (2-ClPh)                                                                             CH.sub.2 CHCH.sub.2                                                            O                       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.2 CHCH.sub.2     H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.2 CHCH.sub.2     H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.2 CHCH.sub.2     H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.2 CHCH.sub.2                                                            A                       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-pyridyl)                                                                          CH.sub.2 CHCH.sub.2                                                            B                       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (Ph)  CH.sub.2 CHCH.sub.2                                                            S                       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      Q-1            CH.sub.2 CHCH.sub.2                                                            T                       H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      Q-3            CH.sub.2 CHCH.sub.2     H       H      CH.sub.2 CH.sub. 3                                                                    CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      Q-6            CH.sub.2 CHCH.sub.2     H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      Q-7            CH.sub.2 CHCH.sub.2     H       H      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.2 CHCH.sub.2                                                                      Q-15           CH.sub.2 CHCH.sub.2     H       H      H      H       CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (2-ClPh)                                                                             CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                H       H      H      H       CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                H       H      H      H       CH.sub.3  Q-1            CH.sub.3                H       H      H      H       CH.sub.3  Q-3            CH.sub.3                H       H      H      H       CH.sub.3  Q-6            CH.sub.3                H       H      H      H       CH.sub.3  Q-7            CH.sub.3                H       H      H      H       CH.sub.3  Q-15           CH.sub.3                H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                              CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-ClPh)                                                                             CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-pyridyl)                                                                          CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph)  CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        Q-1            CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        Q-3            CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        Q-6            CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        Q-7            CH.sub.2 CH.sub.3       H       H      H      H       CH.sub.2 CH.sub.3                                                                        Q-15           CH.sub.2 CH.sub.3       H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub. 3               H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-ClPh)                                                                             CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-1            CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-3            CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-6            CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-7            CH.sub.3                H       H      CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-15           CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-ClPh)                                                                             CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub. 2 CH.sub.3                                                                     CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-1            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-3            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-6            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-7            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-15           CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-ClPh)                                                                             CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-1            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-3            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-6            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-7            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-15           CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub. 2 CH.sub.3                                                                     CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-ClPh)                                                                             CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-CF.sub.3 Ph)                                                                      CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-tetrahydropyran)                                                                  CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-pyridyl)                                                                          CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-1            CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-3            CH.sub. 3               CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-6            CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-7            CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-15           CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              H      H       CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              H      H       CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              H      H       CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              H      H       CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              H      H       CH.sub.3  Q-3            CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.3                                                                               CH.sub.3                                                                              CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-3            CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     H      H       CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     H      H       CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     H      H       CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     H      H       CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     H      H       CH.sub.3  Q-3            CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub. 3                                                                    CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                CH.sub.2 CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              CH.sub.3                                                                               CH.sub.3  Q-3            CH.sub.3                H       CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (Ph)  CH.sub.3                H       CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-FPh)                                                                              CH.sub.3                H       CH.sub.3                                                                              CH.sub. 2 CH.sub.3                                                                    CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                                     CH.sub.3                H       CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                                    CH.sub.3                H       CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                      CH.sub.3  Q-3            CH.sub.3                __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

                  TABLE 9                                                          ______________________________________                                                     Active  Weight Percent*                                                        Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             5-60      39-94     1-10                                         Emulsifiable  3-80      20-95     0-20                                         Concentrates                                                                   Dusts         1-25      70-99     0-5                                          Granules and Pellets                                                                         0.1-50      50-99.9 0-15                                         ______________________________________                                          *Active ingredient plus at least one of a Surfactant or a Diluent equals       100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58. 132, 138-140, 152-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, Jun. 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE A

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                           60%                                                oxabicyclo[2.2.1]heptane                                                       sodium alkylnaphthalenesulfonate                                                                            2%                                                sodium ligninsulfonate       2%                                                synthetic amorphous silica  36%                                                ______________________________________                                    

The active ingredient is first sprayed onto the amorphous silica, then the ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.

EXAMPLE B

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                           50%                                                oxabicyclo[2.2.1]heptane                                                       sodium alkylnaphthalenesulfonate                                                                            2%                                                low viscosity methyl cellulose                                                                              2%                                                diatomaceous earth          46%                                                ______________________________________                                    

The active ingredient is first sprayed onto the diatomaceous earth then the ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diamete. The product is reblended before packaging.

EXAMPLE C

    ______________________________________                                         Granule                                                                        ______________________________________                                         Wettable Powder of Example B                                                                                5%                                                attapulgite granules        95%                                                (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                              ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE D

    ______________________________________                                         Emulsifiable Concentrate                                                       ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                           40%                                                oxabicyclo[2.2.1]heptane                                                       Atlox 3403F                  3%                                                Atlox 3404F                  3%                                                xylene                      54%                                                ______________________________________                                    

The active ingredient and Atlox emulsifiers are dissolved in the solvent, filtered and packaged. Atlox 3403F and 3404F are blends of anionic and ionic emulsifiers from ICI Americas, Inc.

EXAMPLE E

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                            5%                                                oxabicyclo[2.2.1]heptane                                                       attapulgite granules        95%                                                (U.S.S. 20-40 mesh)                                                            ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.

EXAMPLE F

    ______________________________________                                         Granule                                                                        ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                           50%                                                oxabicyclo[2.2.1]heptane                                                       wetting agent                1%                                                crude ligninsulfonate salt  10%                                                (containing 5-20% of the natural                                               sugars)                                                                        attapulgite clay            39%                                                ______________________________________                                    

The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use.

EXAMPLE G

    ______________________________________                                         Concentrated Emulsion                                                          ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                           25%                                                oxabicyclo[2.2.1]heptane                                                       xylene                      25%                                                Atlox 3404F                  5%                                                G1284                        5%                                                ethylene glycol              8%                                                water                       32%                                                ______________________________________                                    

The active ingredient, solvent and emulsifiers are blended together. This solution is added to a mixture of the ethylene glycol and water with stirring.

EXAMPLE H

    ______________________________________                                         Solution                                                                       ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                            5%                                                oxabicyclo[2.2.1]heptane                                                       water                       95%                                                ______________________________________                                    

The compound is added directly to the water with stirring to produce the solution, which may then be packaged for use.

EXAMPLE I

    ______________________________________                                         Dust                                                                           ______________________________________                                         2-(1-ethyl-1-methoxypropyl)-6-(phenylmethoxy)-7-                                                           10%                                                oxabicyclo[2.2.1]heptane                                                       attapulgite                 10%                                                Pyrophyllite                80%                                                ______________________________________                                    

The active ingredient is sprayed onto the attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.

UTILITY

Test results indicate compounds of this invention are active postemergence and, in particular, preemergence herbicides. Many compounds in this invention are useful for the control of selected grass and broadleaf weeds with tolerance to important agronomic crops such as alfalfa (Medicago sativa), barley (Hordeum vulgare), corn (Zea mays), cotton (Gossypium hirsutum), rape (Brassica napus), rice (Oryza sativa), soybean (Glycine max), sugar beet (Beta vulgaris), and wheat (Triticum aestivum). Grass and broadleaf weed species controlled include, but are not limited to, barnyardgrass (Echinochloa crus-galli), blackgrass (Alopecurus myosuroides), crabgrass (Digitaria spp.), foxtail (Setaria spp.), lambsquarters (Chenopodium spp.), teaweed (Sida spinosa), umbrella sedge (Cyperus difformis), and waterchestnut (Eleocharis spp.). Several compounds in this invention are particularly useful for the control of barnyardgrass and selected broadleaf weeds such as umbrella sedge and waterchestnut in upland and paddy rice.

These compounds also have utility for weed control of selected vegetation in specified areas such as around storage tanks, parking lots, highways, and railways; in fallow crop areas; and in citrus and plantation crops such as banana, coffee, oil palm, and rubber. Alternatively, these compounds are useful to modify plant growth.

Rates of application for compounds of this invention rae determined by a number of factors. These factors include: formulation selected, method of application, amount and type of vegetation present, growing conditions, etc. In general terms, the subject compounds should be applied at rates from 0.01 to 20 kg/ha with a preferred rate range of 0.03 to 1 kg/ha. Although a small number of compounds show no herbicidal activity at the rates tested, it is anticipated these compounds have herbicidal activity at higher application rates. One skilled in the art can easily determine application rates necessary for the desired level of weed control.

Compounds of this invention may be used alone or in combination with the commercial herbicides, insecticides, or fungicides. The following list exemplifies some of the herbicides suitable for use in mixtures. A combination of a compound from this invention with one or more of the following herbicides may be particularly useful for weed control.

    ______________________________________                                         Common Name Chemical Name                                                      ______________________________________                                         acetochlor  2-chloro-N-(ethoxymethyl)-N-                                                   (2-ethyl-6-methylphenyl)acetamide                                  aciflurofen 5-[2-chloro-4-(trifluoromethyl)-                                               phenoxy]-2-nitrobenzoic acid                                       acrolein    2-propenal                                                         alachlor    2-chloro-N-(2,6-diethylphenyl)-N-                                              (methoxymethyl)acetamide                                           anilofos    S-4-chloro-N-isopropylcarbaniloyl-                                             methyl-O,O-dimethyl phosphorodi-                                               thioate                                                            ametryn     N-ethyl-N'-(1-methylethyl)-6-                                                  (methylthio)-1,3,5-triazine-2,4-                                               diamine                                                            amitrole    1H-1,2,4-triazol-3-amine                                           AMS         ammonium sulfamate                                                 asulam      methyl [(4-aminophenyl)sulfonyl]-                                              carbamate                                                          atrazine    6-chloro-N-ethyl-N'-(1-methylethyl)-                                           1,3,5-triazine-2,4-diamine                                         barban      4-chloro-2-butynyl 3-chlorocarbamate                               benefin     N-butyl-2-ethyl-2,6-dinitro-4-(tri-                                            fluoromethyl)benzenamine                                           bensulfuron 2-[[[[[(4,6-dimethoxy-2-pyrimi-                                    methyl      dinyl)amino]methylcarbonyl]-                                                   amino]sulfonyl]methylcarbonyl]-                                                acid, methyl ester                                                 bensulide   O,O-bis(1-methylethyl) S-[2-                                                   [(phenylsulfonyl)amio]-                                                        ethyl]phosphorodithioate                                           bentazon    3-(1-methylethyl)-(1H)-2,1,3-                                                  benzothiadiazin-4(3H)-one,                                                     2,2-dioxide                                                        benzofluor  N-[4-(ethylthio)-2-(trifluoro-                                                 methyl)phenyl]methanesulfonamide                                   benzoylprop N-benzoyl-N-(3,4-dichlorophenyl)-DL-                                           alanine                                                            bifenox     methyl 5-(2,4-dichlorophenoxy)-2-                                              nitrobenzoate                                                      bromacil    5-bromo-6-methyl-3-(1-methylpropyl)-                                           2,4(1H,3H)pyrimidinedione                                          bromoxynil  3,5-dibromo-4-hydroxybenzonitrile                                  butachlor   N-(butoxymethyl)-2-chloro-N-(2,6-                                              diethylphenyl)acetamide                                            buthidazole 3-[5-(1,1-dimethylethyl)-1,3,4-thia-                                           diazol-2-yl]-4-hydroxy-1-methyl-2-                                             imidazolidinone                                                    butralin    4-(1,1-dimethylethyl)-N-(1-methyl-                                             propyl)-2,6-dinitrobenzenamine                                     butylate    S-ethyl bis(2-methylpropyl)-                                                   carbamothioate                                                     cacodylic   dimethyl arsinic oxide                                             acid                                                                           CDAA        2-chloro-N,N-di-2-propenylacetamide                                CDEC        2-chloroallyl diethyldithiocarbamate                               CGA 142,464 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-                                          1-[2-(2-methoxyethoxy)-pehnyl-                                                 sulfonyl]-urea                                                     chloroamben 3-amino-2,5-dichlorobenzoic acid                                   chlorbromuron                                                                              3-(4-bromo-3-chlorophenyl)-1-methoxy-1-                                        methylurea                                                         chlorimuron 2-[[[[(4-chloro-6-methoxy-2-pyrimi-                                ethyl       dinyl)ethylamino]carbonyl]-                                                    amino]sulfonyl]benzoic                                                         acid, ethyl ester                                                  chloromethoxy-                                                                             2,4-dichlorophenyl 4-nitro-3-                                      nil         methoxyphenyl ether                                                chlornitrofen                                                                              2,4,6-trichlorophenyl-4-nitro-                                                 phenyl ether                                                       chloroxuron N'-[4-(4-chlorophenoxy)phenyl]-N,N-                                            dimethylurea                                                       chlorpropham                                                                               1-methylethyl 3-chlorophenylcarbamate                              chlorsulfuron                                                                              2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-                                        triazin-2-yl)amino]carbonyl]benzene-                                           sulfonamide                                                        chlortoluron                                                                               N'-(3-chloro-4-methylphenyl)-N,N-                                              dimethylurea                                                       cinmethylin exo-1-methyl-4-(1-methylethyl)-2-[(2-                                          methylphenyl)methoxy]-7-oxabicyclo-                                            [2.2.1]heptane                                                     clethodim   (E,E)-(±)-2-[1-[[(3-chloro-2-propenyl)-                                     oxy]imino]propyl]-5-[2-(ethylthio)-                                            propyl]-3-hydroxy-2-cyclohexen-1-one                               clomazone   2-[(2-chlorophenyl)methyl]-4,4-dimethyl-                                       3-isoxazolidinone                                                  cloproxydim (E,E)-2-[1-[[(3-chloro-2-propenyl)oxy)-                                        imino]butyl]-5-[2-(ethylthio)propyl]-                                          3-hydroxy-2-cyclohexen-1-one                                       clopyralid  3,6-dichloro-2-pyridinecarboxylic acid                             CMA         calcium salt of MAA                                                cyanazine   2-[[4-chloro-6-(ethylamino)-1,3,5-tri-                                         azin-2-yl]amino]-2-methylpropanenitrile                            cycloate    S-ethyl cyclohexylethylcarbamothioate                              cycluron    3-cyclooctyl-1,1-dimethylurea                                      cyperquat   1-methyl-4-phenylpyridinium                                        cyprazine   2-chloro-4-(cyclopropylamino)-6-(iso-                                          propylamino)- .sub.- s-triazine                                    cyprazole   N-[5-(2-chloro-1,1-dimethylethyl)-1,3,4-                                       thiadiazol-2-yl]cyclopropanecarbox-                                            amide                                                              cypromid    3',4'-dichlorocyclopropanecarboxanilide                            dalapon     2,2-dichloropropanoic acid                                         dazomet     tetrahydro-3,5-dimethyl-2H-1,3,5-thia-                                         diazine-2-thione                                                   DCPA        dimethyl 2,3,5,6-tetrachloro-1,4-benzene-                                      dicarboxylate                                                      desmediphan ethyl [3-[[(phenylamino)carbonyl]oxy]-                                         phenyl]carbamate                                                   desmetryn   2-(isopropylamino)-4-(methylamino)-6-                                          (methylthio)- .sub.- s-triazine                                    diallate    S-(2,3-dichloro-2-propenyl)bis(1-                                              methylethyl)carbamothioate                                         dicamba     3,6-dichloro-2-methoxybenzoic acid                                 dichlobenil 2,6-dichlorobenzonitrile                                           dichlorprop (±)-2-(2,4-dichlorophenoxy)propanoic                                        acid                                                               dichlofop   (±)-2-[4-(2,4-dichlorophenoxy)phenoxy]-                                     propanoic acid, methyl ester                                       diethatyl   N-(chloroacetyl)-N-(2,6-diethylphenyl)-                                        glycine                                                            difenzoquat 1,2-dimethyl-3,5-diphenyl-1H-pyrazolium                            dimepiperate                                                                               S-1-methyl-1-phenylethylpiperidine-                                            1-carbothioate                                                     dinitramine N.sup.3,N.sup.3 -diethyl-2,4-dinitro-6-(trifluror-                             methyl)-1,3-benzenediamine                                         dinoseb     2-(1-methylpropyl)-4,6-dinitrophenol                               diphenamid  N,N-dimethyl-α-phenylbenzeneacetamide                        dipropetryn 6-(ethylthio)-N,N'-bis(1-methylethyl)-                                         1,3,5-triazine-2,4-diamine                                         diquat      6,7-dihydrodipyrido[1,2-a:2',1'-c]-                                            pyrazinedium ion                                                   diuron      N'-(3,4-dichlorophenyl)-N,N-dimethylurea                           DNOC        2-methyl-4,6-dinitrophenol                                         DSMA        disodium salt of MAA                                               dymron      N-(4-methylphenyl)-N'-(1-methyl-                                               1-phenylethyl)urea                                                 endothall   7-oxabicyclo[2.2.1]heptane-2,3-dicarbox-                                       ylic acid                                                          EPTC        S-ethyl dipropylcarbamothioate                                     esprocarb   S-benzyl-N-ethyl-N-(1,2-dimethyl)-                                 (SC2957)    propyl)thiolcarbamate                                              ethalfluralin                                                                              N-ethyl-N-(2-methyl-2-propenyl)-2,6-                                           dinitro-4-(trifluoromethyl)-                                                   benzenamine                                                        ethofumesate                                                                               (±)-2-ethoxy-2,3-dihydro-3,3-dimethyl-                                      5-benzofuranyl methanesulfonate                                    fenac       2,3,6-trichlorobenzeneacetic acid                                  fenoxaprop  (±)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]-                                    phenoxy]propanoic acid                                             fenuron     N,N-dimethyl-N'-phenylurea                                         fenuron TCA Salt of fenuron and TCA                                            flamprop    N-benzoyl-N-(3-chloro-4-fluorophenyl)-                                         DL-alanine                                                         fluazifop   (±)-2-[4-[[5-(trifluoromethyl)-2-pyri-                                      dinyl]oxy]phenoxy]propanoic acid                                   fluazifop-P (R)-2-[4-[[5-(trifluoromethyl)-2-pyri-                                         dinyl]oxy]phenoxy]propanoic acid                                   fluchloralin                                                                               N-(2-chlorethyl)-2,6-dinitro-N-propyl-                                         4-(trifluoromethyl)benzenamine                                     fluometuron N,N-dimethyl-N'-[3-(trifluoromethyl)-                                          phenyl]urea                                                        fluorochlor-                                                                               3-chloro-4-(chloromethyl)-1-[3-(tri-                               idone       fluoromethyl)phenyl]-2-pyrrolidinone                               fluorodifen  -p-nitrophenyl α,α,α-trifluoro-2-nitro-                      -p-tolyl ether                                                    fluorogly-  carboxymethyl 5-[2-chloro-4-(tri-                                  cofen       fluoromethyl)phenoxy]-2-nitrobenzoate                              fluridone   1-methyl-3-phenyl-5-[3-(trifluoro-                                             methyl)phenyl]-4(1H)-pyridinone                                    fomesafen   5-[2-chloro-4-(trifluoromethyl)phenoxy]-                                       N-(methylsulfonyl)-2-nitrobenzamide                                fosamine    ethyl hudrogen (aminocarbonyl)-                                                phosphate                                                          glyphosate  N-(phosphonomethyl)glycine                                         haloxyfop   2-[4-[[3-chloro-5-(trifluoromethyl)-2-                                         pyridinyl]oxy]phenoxy]propanoic acid                               hexaflurate potassium hexafluoroarsenate                                                   1,3,5-triazine-2,4(1H,3H)-dione                                    imazametha- 6-(4-isopropyl-4-methyl-5-oxo-2-                                   benz        imidazolin-2-yl)-m-toluic acid,                                                methyl ester and 6-(4-isopropyl-                                               4-methyl-5-oxo-2-imidazolin-2-yl)-                                              -p-toluic acid, methyl ester                                      imazapyr    (±)-2-[4,5-dihydro-4-methyl-4-(1-methyl-                                    ethyl)-5-oxo-1H-imidazol-2-yl]-3-                                              pyridinecarboxylic acid                                            imazaquin   2-[4,5-dihydro-4-methyl-4-(1-methyl-                                           ethyl)-5-oxo-1H-imidazol-2-yl]-3-                                              quinolinecarboxylic acid                                           imazethapyr (±)-2-[4,5-dihydro-4-methyl-4-(1-methyl-                                    ethyl)-5-oxo-1H-imidazol-2-yl]-5-                                              ethyl-3-pyridinecarboxylic acid                                    ioxynil     4-hydroxy-3,5-diiodobenzonitrile                                   isopropalin 4-(1-methylethyl)-2,6-dinitro-N,N-                                             dipropylbenzenamine                                                isoproturon N-(4-isopropylphenyl)-N',N'-dimethylurea                           isouron     N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]-                                       N,N-dimethylurea                                                   isoxaben    N-[3-(1-ethyl-1-methylpropyl)-5-                                               isoxazolyl]-2,6-dimethoxybenzamide                                 karbutilate 3-[[(dimethylamino)carbonyl]amino]-                                            phenyl-(1,1-dimethylethyl)carbamate                                lactofen    (±)-2-ethoxy-1-methyl-2-oxoethyl 5-[2-                                      chloro-4-(trifluoromethyl)phenoxy]-                                            2-nitrobenzoate                                                    lenacil     3-cyclohexyl-6,7-dihydro-1H-cyclopenta-                                        pyrimidine-2,4(3H,5H)-dione                                        linuron     N'-(3,4-dichlorophenyl)-N-methoxy-N-                                           methylurea                                                         MAA         methylarsonic acid                                                 MAMA        monoammonium salt of MAA                                           MCPA        (4-chloro-2-methylphenoxy)acetic acid                              MCPB        4-(4-chloro-2-methylphenoxy)butanoic                                           acid                                                               MON 7200    S,S-dimethyl-2-(difluoromethyl)-4-                                             (2-methylpropyl)-6-(trifluoromethyl)-                                          3,5-pyridinedicarbothionate                                        mecoprop    (±)-2-(4-chloro-2-methylphenoxy)-                                           propanoic acid                                                     mefenacet   2-(2-benzothiazolyloxy-N-methyl-N-                                             phenylacetamide                                                    mefluidide  N-[2,4-dimethyl-5-[[(trifluoromethyl)-                                         sulfonyl]amino]phenyl]acetamide                                    methal-     N-(2-methyl-2-propenyl)-2,6-dinitro-N-                             propalin    propyl-4-(trifluoromethyl)benzenamide                              methabenz-  1,3-dimethyl-3-(2-benzothiazolyl)urea                              thiazuron                                                                      metham      methylcarbamodithioic acid                                         methazole   2-(3,4-dichlorophenyl)-4-methyl-1,2,4-                                         oxadiazolidine-3,5-dione                                           methoxuron  N'-(3-chloro-4-methoxyphenyl)-N,N-                                             dimethylurea                                                       metolachlor 2-chloro-N-(2-ethyl-6-methylphenyl)-N-                                         (2-methoxy-1-methylethyl)acetamide                                 metribuzin  4-amino-6-(1,1-dimethylethyl)-3-(methyl-                                       thio)-1,2,4-triazin-5(4H)-one                                      metsulfuron 2-[[[[(4-methoxy-6-methyl-1,3,5-tri-                               methyl      azin-2-yl)amino]carbonyl]-                                                     amino]sulfonyl]benzoic acid,                                                   methyl ester                                                       MH          1,2-dihydro-3,6-pyridazinedione                                    molinate    S-ethyl hexahydro-1H-azepine-1-carbo-                                          thioate                                                            monolinuron 3-( -p-chlorophenyl)-1-methoxy-1-methyl-                                       urea                                                               monuron     N'-(4-chlorophenyl)-N,N-dimethylurea                               monuron TCA Salt of monuron and TCA                                            MSMA        monosodium salt of MAA                                             napropamide N,N-diethyl-2-(1-naphthalenyloxy)-                                             propanamide                                                        naptalam    2-[(1-naphthalenylamino)carbonyl]-                                             benzoic acid                                                       neburon     1-butyl-3-(3,4-dichlorophenyl)-1-methyl-                                       urea                                                               nitralin    4-(methylsulfonyl)-2,6-dinitro-N,N-                                            dipropylaniline                                                    nitrofen    2,4-dichloro-1-(4-nitrophenoxy)benzene                             nitrofluorofen                                                                             2-chloro-1-(4-nitrophenoxy)-4-(tri-                                            fluoromethyl)benzene                                               norea       N,N-dimethyl-N'-(octahydro-4,7-methano-                                        1H-inden-5-yl)urea 3aα,-                                                 4α,5α,7α,7aα-isomer                                    pyridazinone                                                       oryzalin    4-(dipropylamino)-3,5-dinitro-                                                 benzenesulfonamide                                                 oxadiazon   3-[2,4-dichloro-5-(1-methylethoxy)-                                            phenyl]-5-(1,1-dimethylethyl)-                                                 1,3,4-oxadiazol-2(3H)-one                                          oxyfluorfen 2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-                                        (trifluoromethyl)benzene                                           paraquat    1,1'-dimethyl-4,4'-dipyridinium ion                                pebulate    S-propyl butylethylcarbamothioate                                  pendimethalin                                                                              N-(1-ethylpropyl)-3,4-dimethyl-2,6-                                            dinitrobenzenamine                                                 perfluidone 1,1,1-trifluoro-N-[2-methyl-4-(phenyl-                                         sulfonyl)phenyl]methanesulfonamide                                 phenmedipham                                                                               3-[(methoxycarbonyl)amino]phenyl (3-                                           methylphenyl)carbamate                                             picloram    4-amino-3,5,6-trichloro-2-pyridine-                                            carboxylic acid                                                    PPG-1013    5-[2-chloro-4-(trifluoromethyl)-                                               phenoxy]-2-nitroacetophenone                                                   oxime-O-acetic acid, methyl ester                                  pretilachlor                                                                               α-chloro-2,6-diethyl-N-(2-propoxy-                                       ethyl)acetanilide                                                  procyazine  2-[[4-chloro-6-(cyclopropylamino)-1,3,5-                                       triazine-2-yl]amino]-2-methylpropane-                                          nitrile                                                            profluralin N-(cyclopropylmethyl)-2,6-dinitro-N-                                           propyl-4-(trifluoromethyl)benzenamine                              prometon    6-methoxy-N,N'-bis(1-methylethyl)-1,3,5-                                       triazine-2,4-diamine                                               prometryn   N,N'-bis(1-methylethyl)-6-(methylthio)-                                        1,3,5-triazine-2,4-diamine                                         pronamide   3,5-dichloro-N-(1,1-dimethyl-2-propyn-                                         yl)benzamide                                                       propachlor  2-chloro-N-(1-methylethyl)-N-                                                  phenylacetamide                                                    propanil    N-(3,4-dichlorophenyl)propanamide                                  propazine   6-chloro-N,N'-bis(1-methylethyl)-                                              1,3,5-triazine-2,4-diamine                                         propham     1-methylethyl phenylcarbamate                                      prosulfalin N-[[4-(dipropylamino)-3,5-dinitro-                                             phenyl]sulfonyl]-S,S-dimethylsulfil-                                           imine                                                              prynachlor  2-chloro-N-(1-methyl-2-propynyl)acet-                                          anilide                                                            pyrazolate  4-(2,4-dichlorobenzoyl)-1,3-dimethyl-                                          pyrazol-5-yl- -p-toluenesulphonate                                 pyrazon     5-amino-4-chloro-2-phenyl-3(2H)-                                               pyridazinone                                                       pyrazosulfuron                                                                             ethyl S-[3-(4,6-dimethoxypyrimidin-2-                              ethyl       yl)ureadosulfonyl]-1-methylpyrazole-                                           4-carboxylate                                                      quinclorac  3,7-dichloro-8-quinoline carboxylic acid                           quizalofop  (±)-2-[4-[(6-chloro-2-quinoxylinyl)-                            ethyl       oxy]phenoxy]propanoic acid, ethyl                                              ester                                                              secbumeton  N-ethyl-6-methoxy-N'-(1-methylpropyl)-                                         1,3,5-triazine-2,4-diamine                                         sethoxydim  2-[1-(ethoxyimino)butyl]-5-[2-(ethyl-                                          thio)propyl]-3-hydroxy-2-cyclohexen-                                           1-one                                                              siduron     N-(2-methylcyclohexyl)-N'-phenylurea                               simazine    6-chloro-N,N'-diethyl-1,3,5-triazine-                                          2,4-diamine                                                        SK-233      1-(α,α-dimethylbenzyl)-3-(4-methyl-                                phenyl)urea                                                        sulfometuron                                                                               2-[[[[(4,6-dimethyl-2-pyrimidinyl)-                                methyl      amino]carbonyl]amino]sulfonyl]-                                                benzoic acid, methyl ester                                         TCA         trichloroacetic acid                                               tebuthiuron N-[5-(1,1-dimethylethyl)-1,3,4-thiadi-                                         azol-2-yl]-N,N'-dimethylurea                                       terbacil    5-chloro-3-(1,1-dimethylethyl)-6-                                              methyl-2,4(1H,3H)-pyrimidinedione                                  terbuchlor  N-(butoxymethy)-2-chloro-N-[2-(1,1-                                            dimethylethyl)-6-methylphenyl]-                                                acetamide                                                          terbuthyl-  2-(tert-butylamino)-4-chloro-6-(ethyl-                             azine       amino)- .sub.- s-triazine                                          terbutol    2,6-di-tert-butyl- -p-tolyl methylcar-                                         bamate                                                             terbutryn   N-(1,1-dimethylethyl)-N'-ethyl-6-                                              (methylthio)-1,3,5-triazine-                                                   2,4-diamine                                                        thifensulfuron                                                                             3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-                           methyl      2-yl)amino]carbonyl]amino] sulfonyl]-                                          2-thiophenecarboxylic acid, methyl                                             ester                                                              thiobencarb S-[(4-chlorophenyl)methyl] diethylcar-                                         bamothioate                                                        triallate   S-(2,3,3-trichloro-2-propenyl)  bis(1-                                         methylethyl)carbamothioate                                         tribenuron  2-[[[[N-(4-methoxy-6-methyl-1,3,5-                                 methyl      triazine-2-yl)-N-methylamino]-                                                 carbonyl]amino]sulfonyl]benzoic                                                acid, methyl ester                                                 triclopyr   [3,5,6-trichloro-2-pyridinyl)-                                                 oxy]acetic acid                                                    tridiphane  2-(3,5-dichlorophenyl)-2-(2,2,2-                                               trichloroethyl)oxirane                                             trifluralin 2,6-dinitro-N,N-dipropyl-4-(tri-                                               fluoromethyl)benzenamine                                           trimeturon  1-( -p-chlorophenyl)-2,3,3-trimethylpseu-                                      dourea                                                             2,4-D       (2,4-dichlorophenoxy)acetic acid                                   2,4-DB      4-(2,4-dichlorophenoxy)butanoic acid                               vernolate   S-propyl dipropylcarbamothioate                                    xylachlor   2-chloro-N-(2,3-dimethylphenyl)-N-                                             (1-methylethyl)acetamide                                           ______________________________________                                    

Herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. Test procedures and results follow.

                                      TABLE 10                                     __________________________________________________________________________      ##STR28##                                                                                                                    Physical                                                                       Properties                                                                     Configuration                                                                         Partial                  Cmpd                                                                               R.sup.1                                                                           R.sup.2                                                                           R.sup.3  R.sup.4  R.sup.5   Q        Ratio (I:(18))                                                                        NMR(δ)             __________________________________________________________________________      1  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 Ph                                                                              CH.sub.2 (Ph)                                                                           oil, exo,                                                                             4.58-4.36(m, 2H),                                                              3.54(m, 2H),                                                                   3.20(m, 1H),              2  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-FPh)                                                                        oil, exo,                                                                             5.90(m, 1H),                                                                   5.32-5.06(m, 2H),                                                              4.54(dq, 2H),                                                                  3.94(m, 2H),                                                                   3.6-3.43(m, 2H),                                                               3.16(m, 1H)               3  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo,                                                                             5.90(m, 1H),                                                                   5.28-5.15(m, 2H),                                                              4.44(dq, 2H),                                                                  3.84(m, 2H),                                                                   3.55-3.43(m, 2H),                                                              3.15(m, 1H)               4  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (Ph)                                                                           oil, exo,                                                                             5.90(m, 1H),                                                                   5.3-5.16(m, 2H)                                                                4.49(dq, 2H),                                                                  3.94(m, 2H),                                                                   3.58-3.42(m, 2H),                                                              3.16(m, 1H)               5  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.52(dd, 2H),                                                                  3.56(dd, 1H),                                                                  3.43(dd, 1H),                                                                  3.3(s, 3H),                                                                    3.12(dd, 1H)              6  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-F.sub.2 Ph)                                                               oil, endo                                                                             3.3(m, 4H),                                                                    4.60(d, 1H),                                                                   4.5(d, 1H),                                                                    3.76(dd, 1H)              7  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2 Ph)                                                              oil, endo                                                                             4.76(d, 1H),                                                                   4.66(d, 1H),                                                                   3.74(dd, 1H),                                                                  3.3(m, 4H),               8  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                        oil, exo,                                                                             4.58(d, 1H),                                                                   4.45(d, 1H),                                                                   3.56(dd, 1H),                                                                  3.4-3.1(m, 4H)            9  CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2,6-Cl.sub.2 Ph)                                                              oil, exo,                                                                             4.73(dd, 1H),                                                                  4.64(dd, 1H),                                                                  3.5(m, 2H),                                                                    3.4-3.1(m, 4H)            10 CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                              oil, exo,                                                                             4.73(dd, 1H),                                                                  4.64(dd, 1H),                                                                  3.5(m, 2H),                                                                    3.08(dd+dd,                                                                    1H-1:1 ratio)             11 CH.sub.3                                                                          CH.sub.3                                                                          H        H        Et        CH.sub.2 (2-BrPh)                                                                       oil, exo,                                                                             4.56(d, 1H),                                                                   4.43(dd, 1H),                                                                  3.60(dd, 1H),                                                                  3.5(m, 3H),                                                                    3.12(dd+dd, 1H),          12 CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.3  CH.sub.2 (2-BrPh)                                                                       oil, exo,                                                                             4.58(d, 1H),                                                                   4.42(dd, 1H),                                                                  3.61 (dd, 1H),                                                                 3.45(m, 1H)                                                                    3.3(s+s, 3H),                                                                  3.1(dd+dd, 1H)            13 CH.sub.3                                                                          CH.sub.3                                                                          H        H        Et        CH.sub.2 (2-ClPh)                                                                       oil, endo                                                                             4.61(d, 1H),                                                                   4.56(d, 1H),                                                                   3.82(dd, 1H),                                                                  3.35(m, 4H)               14 CH.sub.3                                                                          CH.sub.3                                                                          H        H        Et        CH.sub.2 (2-BrPh)                                                                       oil, endo                                                                             4.59(d, 1H),                                                                   4.43(d, 1H),                                                                   3.84(dd, 1H),                                                                  3.25(m, 4H),              15 CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CHCH(CH.sub.3)                                                                  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              5.61(m, 2H),                                                                   4.56(d, 1H),                                                                   4.50(d, 1H),                                                                   3.9(d+d, 2H)                                                                   3.5(dd+dd, 2H),                                                                3.14(dd, 1H)              16 CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 OCH.sub.3                                                                       CH.sub.2 (2-FPh)                                                                        oil, endo                                                                             4.56(dd+s, 4H),                                                                3.81(dd, 1H),                                                                  3.45(dd, 2H),                                                                  3.29(s, 3H)               17 CH.sub.3                                                                          CH.sub.3                                                                          H        H        CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.53(d, 1H),                                                                   4.35(d, 1H),                                                                   3.45(m, 4H),                                                                   3.13(dd, 1H)              18 H  H  CH.sub.3 CH.sub.3 CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.6(br, 1H),                                                                   4.50(m, 3H),                                                                   3.65(dd, 1H),                                                                  3.18(s, 3H)               21 H  H  CH.sub.3 CH.sub.3 CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.55(t, 1H),                                                                   4.49(m, 3H),                                                                   3.64(dd, 1H),                                                                  3.16(s, 3H)               22 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.59(d, 1H),                                                                   4.45(d, 1H),                                                                   3.55(dd, 1H),                                                                  3.38(dq, 2H)              23 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.52(dd, 1H),                                                                  4.40(dd, 1H),                                                                  3.52(dd, 1H),                                                                  3.37(dq, 2H)              25 H  H  Et       Et       CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.65(m, 4H),                                                                   3.72(dd, 1H),                                                                  3.22(s, 3H)               26 H  H  Et       Et       CH.sub.3  CH.sub.2 (2,6-Cl.sub.2 Ph)                                                              oil, exo                                                                              4.75(dd, 2H),                                                                  4.59(m, 2H),                                                                   3.75(dd, 1H),                                                                  3.18(s, 3H)               27 H  H  Et       Et       CH.sub.3  CH.sub.2 (2-(CH.sub.3)-Ph)                                                              oil, exo                                                                              4.7(m, 4H),                                                                    3.7(dd, 1H),                                                                   3.2(s, 3H)                28 H  H  Et       Et       CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.7(m, 4H),                                                                    3.73(dd, 1H),                                                                  3.2(s, 3H)                29 H  H  Et       Et       CH.sub.3  CH.sub.2 (2-ClPh)                                                                       oil, exo                                                                              4.7(m, 4H),                                                                    3.72(dd, 1H),                                                                  3.2(s, 3H)                30 H  H  Et       Et       CH.sub.3  CH.sub.2 (2-BrPh)                                                                       oil, exo                                                                              4.59(brd, 4H),                                                                 3.71(dd, 1H),                                                                  3.18(s, 3H)               31 H  H  Et       Et       CH.sub.3  CH.sub.2 (2,6-F.sub.2 Ph)                                                               oil, exo                                                                              4.56(m, 4H),                                                                   3.68(dd, 1H),                                                                  3.17(s, 3H)               32 H  H  n-Pr     n-Pr     CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.52(m, 4H),                                                                   3.62(dd, 1H),                                                                  3.15(s, 3H),              33 H  H  n-Pr     n-Pr     CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.50(t, 1H),                                                                   4.48(s, 1H),                                                                   4.45(dd, 2H),                                                                  3.62(dd, 1H),                                                                  3.19(s, 3H)               34 H  H  n-Pr     n-Pr     CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.50(m, 4H),                                                                   3.65(dd, 1H),                                                                  3.16(s, 3H)               35 H  H  n-Pr     n-Pr     CH.sub.3  CH.sub.2 (2-ClPh)                                                                       oil, exo                                                                              4.59(m, 4H),                                                                   3.68(dd, 1H),                                                                  3.17(s, 3H)               36 H  H  n-Pr     n-Pr     CH.sub.3  CH.sub.2 (2-BrPh)                                                                       oil, exo                                                                              4.50(m, 4H),                                                                   3.69(dd, 1H),                                                                  3.17(s, 3H)               37 H  H  n-Pr     n-Pr     CH.sub.3  CH.sub.2 (2,6-F.sub.2 Ph)                                                               oil, exo                                                                              4.50(m, 4H),                                                                   3.67(dd, 1H),                                                                  3.16(s, 3H)                40                                                                               H  H  Pr       Pr       CH.sub.2 Ph                                                                              CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.9-4.6(m, 6H),                                                                3.8(dd, 1H)               41 H  H  n-Pr     n-Pr     CH.sub.2 (2-CH.sub.3 (Ph))                                                               CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.6-4.4(m, 6H),                                                                3.6(dd, 1H)               42 H  H  n-Pr     n-Pr     CH.sub.2 (2-F(Ph))                                                                       CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.6(m, 6H),                                                                    3.72(dd, 1H)              48 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph)                                                                           oil, exo                                                                              5.95-5.7(m, 2H),                                                               5.4-5.1(m, 4H),                                                                4.6-4.45(m, 4H),                                                               3.68(dd, 1H),                                                                  3.35(q, 2H)               49 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-CH.sub.3)Ph)                                                                oil, exo                                                                              5.95-5.7(m, 2H),                                                               5.4-5.15(m, 4H),                                                               4.65-4.4(m, 2H),                                                               3.68(dd, 1H),                                                                  3.33(q, 1H)               50 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              5.95-5.6(m, 2H),                                                               5.36-5.16(m, 4H),                                                              4.57(m, 4H),                                                                   3.72(dd, 1H),                                                                  3.33(q, 2H)               51 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 (Ph)                                                                           oil, exo                                                                              6.0-5.8(m, 2H),                                                                5.15-5.0(m, 4H),                                                               4.61=4.4(m, 4H),                                                               3.62(dd, 1H),                                                                  3.45(q, 2h)               52 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH2CH.sub.3                                                                              CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              5.8-6.0(m, 2H),                                                                5.15-5.0(m, 4H),                                                               4.6-4.4(m, 4H),                                                                3.62(dd, 1H),                                                                  3.46(q, 2H)               53 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CH.sub.3                                                                        CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              6.0-5.72(m, 2H),                                                               5.2-4.95(m, 4H),                                                               4.58(m, 4H),                                                                   3.65(dd, 1H),                                                                  3.45(q, 2H)               54 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              6.0-5.75(m, 2H),                                                               5.15-5.0(m, 4H),                                                               4.62-4.4(m, 4H),                                                               3.62(dd, 1H),                                                                  3.25(s, 3H)               55 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              5.9(m, 2H),                                                                    5.15-5.0(m, 4H),                                                               4.6-4.4(m, 4H),                                                                3.62(dd, 1H),                                                                  3.26(s, 3H)               56 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              6.0-5.75(m, 2H),                                                               5.1-5.0(m, 4H),                                                                4.5(m, 4H),                                                                    3.65(dd, 1H),                                                                  3.26(s, 3H)               57 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              6.95-6.8 (dd, 2H),                                                             6.04-5.75(m, 2H),                                                              5.15-5.00(m, 2H),                                                              4.55(m, 4H),                                                                   3.66(dd, 1H),                                                                  3.26(s, 3H)               58 H  H  CH.sub.2 CHCH.sub.2                                                                     CH.sub.2 CHCH.sub.2                                                                     CH.sub.3  CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            oil, exo                                                                              6.02-5.75(m, 2H),                                                              5.15-5.04(m, 4H),                                                              4.8-4.55(m, 4H),                                                               3.70(dd, 1H),                                                                  3.27(q, 3H)               59 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (Ph)                                                                           oil, exo                                                                              6.0-5.8(dd+1H),                                                                5.28(dd, 1H),                                                                  5.10(dd, 1H),                                                                  4.58(brs, 2H),                                                                 4.51(d, 2H),                                                                   3.82(d, 2H),                                                                   3.62(dd, 1H)              60 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              6.0-5.8(m, 1H),                                                                5.26(dd, 1H),                                                                  5.10(dd, 1H),                                                                  4.58(br, 4H),                                                                  3.85(d, 2H),                                                                   3.65(dd, 1H)              61 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              6.88(t, 2H),                                                                   6.0-5.79(m, 1H),                                                               5.28(dd, 1H),                                                                  5.10(dd, 1H),                                                                  4.56(m, 4H),                                                                   3.87(m, 2H),                                                                   3.65 (dd, 1H)             62 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.2                                                               CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              6.0-5.78(m, 1H),                                                               5.27(dd, 1H),                                                                  5.09(dd, 1H),                                                                  4.59(br, 2H),                                                                  4.50(dd, 2H)              63 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.66(m, 2H),                                                                   4.58(m, 2H),                                                                   3.73(dd, 1H),                                                                  3.27(s, 3H)               64 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.62(m, 1H),                                                                   3.72(dd, 1H),                                                                  3.28(s, 3H)               65 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (2-ClPh)                                                                       oil, exo                                                                              4.66(m, 4H),                                                                   3.75(dd, 1H),                                                                  3.26(s, 3H)               66 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.65(m, 2H),                                                                   4.52(m, 2H),                                                                   3.7(dd, 1H),                                                                   3.26(s, 3H)               67 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (2-BrPh)                                                                       oil, exo                                                                              4.59(m, 4H),                                                                   3.72(m, 1H),                                                                   3.24(s, 3H)               68 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              4.58(m, 4H),                                                                   3.7(dd, 1H),                                                                   3.26(s, 3H)               69 H  H  CH.sub.2 CH(CH).sub.3                                                                   CH.sub.2 CH(CH).sub.3                                                                   CH.sub.3  CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            oil, exo                                                                              4.78(m, 3H),                                                                   4.5(t, 1H),                                                                    3.83(dd, 1H),                                                                  3.22(s, 3H)               70 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.2 CHCH.sub.2                                                                      CH.sub.2 (Ph)                                                                           oil, exo                                                                              6.0-5.8(m, 1H),                                                                5.4-5.05(m, 2H),                                                               4.55(m, 4H),                                                                   3.9(dd, 2H),                                                                   3.65(dd, 2H)              71 H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.55(m, 4H),                                                                   3.63(dd, 1H),                                                                  3.15(s, 3H)               72 H  H  CH.sub. 2 CH.sub.2 CH.sub.2 CH.sub.3                                                    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.58(m, 4H),                                                                   3.63(dd, 1H),                                                                  3.17(s, 3H)               73 H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-ClPh)                                                                       oil, exo                                                                              4.6(m, 4H),                                                                    3.69(dd, 1H),                                                                  3.17(s, 3H)               74 H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.6-4.42(m, 4H),                                                               3.62(dd, 1H),                                                                  3.17(s, 3H)               75 H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-BrPh)                                                                       oil, exo                                                                              4.58(m, 4H),                                                                   3.7(dd, 1H),                                                                   3.17(s, 3H)               76 H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              4.57(m, 4H),                                                                   3.63(dd, 1H),                                                                  3.16(s, 3H)               77 H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            oil, exo                                                                              4.74(brm, 2H),                                                                 4.58(br, 2H),                                                                  3.70(dd, 1H)                                                                   3.17(s, 3H)               78 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2,4-(F).sub.2 Ph)                                                             oil, exo                                                                              6.8(m, 2H),                                                                    4.59(t, 1H),                                                                   4.51(m, 3H),                                                                   3.64(dd, 1H),                                                                  3.17(s, 3H)               79 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (4-FPh)                                                                        oil, exo                                                                              4.61(t, 1H),                                                                   4.54(d, 1H),                                                                   4.48(d+s, 2H),                                                                 3.16(s, 3H)               80 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (3-FPh)                                                                        oil, exo                                                                              4.55(t+d+d+s,                                                                  4H), 4.64(d+d,                                                                 -        1H),                                                                  3.18(s, 3H)               81 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2,5-(F).sub.2 Ph)                                                             oil, exo                                                                              4.5(m, 4H),                                                                    3.64(dd, 1H),                                                                  3.17(s, 3H)               82 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (3-ClPh)                                                                       oil, exo                                                                              4.6(t, 1H),                                                                    4.55(s, 1H),                                                                   4.48(d+d, 2H),                                                                 3.62(dd, 1H),                                                                  3.16(s, 3H)               83 H  H  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.3  CH.sub.2 (2,4-(F).sub.2 Ph)                                                             oil, exo                                                                              6.8(m, 2H),                                                                    4.53(m, 4H),                                                                   3.68(dd, 1H),                                                                  3.28(s, 3H)               84 H  H  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.3  CH.sub.2 (4-FPh)                                                                        oil, exo                                                                              4.6-4.5(m, 4H),                                                                3.62(dd, 1H),                                                                  3.22(s, 3H)               85 H  H  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.3  CH.sub.2 (3-FPh)                                                                        oil, exo                                                                              4.6-4.5(m, 4H),                                                                3.63(dd, 1H),                                                                  3.23(s, 3H)               86 H  H  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.3  CH.sub.2 (2,5-(F).sub.2 Ph)                                                             oil, exo                                                                              4.6(m, 4H),                                                                    3.66(dd, 1H),                                                                  3.23(s, 3H)               87 H  H  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.2 CH(CH.sub.3)2                                                                  CH.sub.3  CH.sub.2 (3-ClPh)                                                                       oil, exo                                                                              4.62(m, 2H),                                                                   4.5(m, 2H),                                                                    3.62(dd, 1H),                                                                  3.28(s, 3H)               88 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (4-(F).sub.2 Ph)                                                               oil, exo                                                                              4.6-4.5(m, 4H),                                                                3.64(dd, 1H),                                                                  3.17(s, 3H)               89 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (4-FPh)                                                                        oil, exo                                                                              4.6-4.5(m, 4H),                                                                3.61(dd, 1H),                                                                  3.16(s, 3H)               90 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (3-FPh)                                                                        oil, exo                                                                              4.7-4.4(m, 4H),                                                                3.64(dd, 1H),                                                                  3.16(s, 3H)               91 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (2,5-(F).sub.2 Ph)                                                             oil, exo                                                                              4.8-4.5(m, 4H),                                                                3.70(dd, 1H),                                                                  3.18(s, 3H)               92 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (3-ClPh)                                                                       oil, exo                                                                              4.7-4.4(m, 4H),                                                                3.63(dd, 1H),                                                                  3.17(s, 3H)               93 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.6-4.5(m, 4H),                                                                3.65(dd, 1H),                                                                  3.15(s, 3H)               94 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.3 (2-FPh)                                                                        oil, exo                                                                              4.58(m, 4H),                                                                   3.7(dd, 1H),                                                                   3.16(s, 3H)               95 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              5.8(m, 2H),                                                                    5.3(m, 4H),                                                                    4.54(m, 4H),                                                                   3.69(dd, 1H),                                                                  3.15(s, 3H)               96 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              5.8(m, 2H),                                                                    5.27(m, 4H),                                                                   4.57(m, 4H),                                                                   3.70(dd, 1H),                                                                  3.16(s, 3H)               97 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              5.8(m, 2H),                                                                    5.3(m, 4H),                                                                    4.53(m, 4H),                                                                   3.70(dd, 1H),                                                                  3.16(s, 3H)               98 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.3  CH.sub.2 (4-FPh)                                                                        oil, exo                                                                              5.8(m, 2H),                                                                    5.3(m, 4H),                                                                    4.5(m, 4H),                                                                    3.65(dd, 1H),                                                                  3.16(s, 3H)               99 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.3  CH.sub.2 (2,4-(F).sub.2 Ph)                                                             oil, exo                                                                              5.8(m, 2H),                                                                    5.3(m, 4H),                                                                    4.51(m, 4H),                                                                   3.70(dd, 1H),                                                                  3.16(s, 3H)              100 H  H  CHCH.sub.2                                                                              CHCH.sub.2                                                                              CH.sub.3  CH.sub.2 (2,5-(F).sub.2 Ph)                                                             oil, exo                                                                              5.8(m, 2H),                                                                    5.3(m, 4H),                                                                    4.55(m, 4H),                                                                   3.70(dd, 1H),                                                                  3.17(s, 3H)              101 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2-ClPh)                                                                       oil, exo                                                                              4.61(br, 4H),                                                                  3.71(dd, 1H),                                                                  3.17(s, 3H)              102 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              4.57(m, 4H),                                                                   3.7(dd, 1H),                                                                   3.17(s, 3H)              103 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.6(m, 2H),                                                                    4.5(d+d, 2H)                                                                   3.64(dd, 1H),                                                                  3.16(s, 3H)              104 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2,4-(F).sub.2 Ph)                                                             oil, exo                                                                              4.58(br, 2H),                                                                  4.52(br, 2H)                                                                   3.7(dd, 1H),                                                                   3.16(s, 3H)              105 H  H  CH.sub.2 CH.sub.3                                                                       CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (2-tetra-                                                                      oil, exo                                                                              4.59(t, 1H),                                                   hydropyran)     4.5(s, 1H)                                                                     3.5(dd, 1H),                                                                   3.4(m, 2H),                                                                    3.31(m, 4H),                                                                   3.18(s, 3H)              106 H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3  CH.sub.2 (2-tetra-                                                                      oil, exo                                                                              4.5(t+s, 1H),                                                  hydropyran)     3.5-3.3(m, 6H)                                                                 3.17(s, 3H)              107 H  H  CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.5(m, 4H),                                                                    3.7(dd, 1H)                                                                    3.15(s, 3H)              108 H  H  CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.59(brs, 4H),                                                                 3.7(dd, 1H)                                                                    3.16(s, 3H)              109 H  H  CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              4.58(brs, 4H),                                                                 3.71(dd, 1H)                                                                   3.17(s, 3H)              110 H  H  CH.sub.3 CH.sub.2 CH.sub.3                                                                       CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.5(m, 4H),                                                                    3.69(dd, 1H)                                                                   3.16(s, 3H)              111 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (Ph)                                                                           oil, exo                                                                              4.5(m, 4H),                                                                    3.69(dd, 1H)                                                                   3.15(s, 3H)              112 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-FPh)                                                                        oil, exo                                                                              4.58(m, 4H),                                                                   3.7(dd, 1H)                                                                    3.16(s, 3H)              113 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-ClPh)                                                                       oil, exo                                                                              4.6(m, 4H),                                                                    3.71(dd, 1H)                                                                   3.17(s, 3H)              114 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, exo                                                                              4.5(m, 4H),                                                                    3.69(dd, 1H)                                                                   3.16(s, 3H)              115 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, exo                                                                              4.57(m, 4H),                                                                   3.7(dd, 1H)                                                                    3.17(s, 3H)              116 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            oil, exo                                                                              4.61(s, 1H),                                                                   4.59(t, 1H),                                                                   3.71(dd, 1H)                                                                   3.17(s, 3H)              117 H  H  CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     CH.sub.3  CH.sub.2 (2,4-(F).sub.2 Ph)                                                             oil, exo                                                                              4.5(m, 1H),                                                                    3.7(dd, 1H)                                                                    3.16(s,                  __________________________________________________________________________                                                           3H)                 

                                      TABLE 11                                     __________________________________________________________________________      ##STR29##                                                                                                           Physical                                                                       Properties  Partial                      Cmpd   R.sup.1                                                                            R.sup.2                                                                             R.sup.3                                                                            R.sup.4                                                                             R.sup.5                                                                               W     Configuration                                                                              NMR (δ)                __________________________________________________________________________     43     H   H    H   H    CH.sub.2 CH.sub.3                                                                     2-FPh exo, oil, exo                                                                              4.5 (d, d, 4H),                                                                3.78 (dd, 1H),                                                                 3.45-3.28 (m, 8H)            44     H   H    H   H    CH.sub.3                                                                              Ph    exo, oil, exo                                                                              4.52 (d, d, 4H),                                                               3.63 (m, 5H),                                                                  3.5-3.3 (s + s, 6H),         45     H   H    H   H    CH.sub.3                                                                              2-FPh exo, oil, exo                                                                              4.62 (d, 1H),                                                                  4.51 (d, 1H),                                                                  3.6-3.3 (m, 13H)             46     H   H    H   H    CH.sub.2 CH.sub.3                                                                     2-(CH.sub.3)Ph                                                                       exo, oil, exo                                                                              4.48 (d, d, 4H),                                                               3.75 (dd, 1H),                                                                 3.4 (m, 8H)                  47     H   H    H   H    CH.sub.2 CH.sub.3                                                                     Ph    exo, oil, exo                                                                              4.5 (m, 4H),                                                                   3.75 (dd, 1H),                                                                 3.4 (m,                      __________________________________________________________________________                                                       8H)                     

                                      TABLE 12                                     __________________________________________________________________________      ##STR30##                                                                                                                 Physical                                                                       Properties                                                                              Partial                   Cmpd R.sup.1                                                                              R.sup.3                                                                            R4 R.sup.5                                                                              R.sup.9                                                                             R.sup.10                                                                             Q        Configuration                                                                           NMR                       __________________________________________________________________________                                                          (δ)                 118  CH.sub.3                                                                             H   H  CH.sub.3                                                                             H    H     CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.64 (d, 1H)                                                                   4.44 (d, 1H),                                                                  3.82 (m, 2H),                                                                  3.32 (s, 3H),                                                                  3.21 (m, 3H)              119  CH.sub.3                                                                             H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-FPh)                                                                        oil, endo                                                                               4.6 (m, 1H)                                                                    3.8 (m, 2H),                                                                   3.31 (s, 3H),                                                                  3.2 (m, 3H),              120  CH.sub.3                                                                             H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, endo                                                                               4.65 (d, 1H)                                                                   4.48 (d, 1H),                                                                  3.78 (m, 2H),                                                                  3.32 (s, 3H),                                                                  3.2 (m, 3H)               121  H     H   H  CH.sub.2 CH.sub.3                                                                    H    H     CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.36 (d + d, 1H),                                                              4.40 (d, 1H),                                                                  3.91 (d, 1H),                                                                  3.75 (dd, 1H),                                                                 3.45 (m, 3H),                                                                  3.25 (d, 2H)              122  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.40 (d, 1H),                                                                  3.90 (d, 1H),                                                                  3.7 (dd, 2H),                                                                  3.31 (s, 3H),                                                                  3.3 (m, 1H)                                                                    3.1 (m, 2H)               123  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-FPh)                                                                        oil, endo                                                                               4.62 (s, 2H),                                                                  4.40 (d, 1H),                                                                  3.90 (d, 1H),                                                                  3.71 (dd, 1H),                                                                 3.32 (s, 3H),                                                                  3.21 (m, 2H)              124  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, endo                                                                               4.53 (dd, 2H),                                                                 4.39 (d, 1H),                                                                  3.90 (d, 1H),                                                                  3.7 (dd, 1H),                                                                  3.31 (s, 3H),                                                                  3.31 (m, 1H),                                                                  3.10 (m, 2H)              125  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-ClPh)                                                                       oil, endo                                                                               4.64 (s, 2H),                                                                  4.40 (d, 1H),                                                                  3.9 (d, 1H),                                                                   3.72 (dd, 1H),                                                                 3.4 (dd, 1H),                                                                  3.32 (s, 3H),                                                                  3.2 (m, 2H)               126  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, endo                                                                               4.61 (s, 2H),                                                                  4.4 (d, 1H),                                                                   3.9 (d, 1H),                                                                   3.7 (dd, 1H),                                                                  3.38 (dt, 1H),                                                                 3.32 (s, 3H),                                                                  3.2 (d + d, 2H)           127  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,4-(F).sub.                                                                  oil, endo                                                                               4.56 (s, 2H),                                                                  4.38 (d, 1H),                                                                  3.89 (d, 1H),                                                                  3.72 (dd, 1H),                                                                 3.38 (m, 1H),                                                                  3.31 (s, 3H),                                                                  3.20 (d + d, 2H)          128  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,5-(F).sub.2 Ph)                                                             oil, endo                                                                               4.59 (s, 2H),                                                                  4.40 (d, 1H),                                                                  3.90 (d, 1H),                                                                  3.75 (dd, 1H),                                                                 3.38 (m, 1H),                                                                  3.33 (s, 3H),                                                                  3.2 (m, 2H)               129  H     H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            oil, endo                                                                               4.78 (dd, 2H),                                                                 4.43 (d, 1H),                                                                  3.9 (d, 1H),                                                                   3.7 (dd, 1H),                                                                  3.4 (m, 1H),                                                                   3.32 (s, 3H),                                                                  3.2 (dd, 2H)              130  CH.sub.3                                                                             H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, endo                                                                               4.63 (d, 1H),                                                                  4.41 (d, 1H),                                                                  3.84 (m, 1H),                                                                  3.4-3.2, (m, 6H)          131  CH.sub.3                                                                             H   H  CH.sub.2 CH.sub.3                                                                    H    H     CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.65 (d, 1H),                                                                  4.45 (d, 1H),                                                                  3.85 (d + dd, 1H),                                                             3.44 (dq, 6H),                                                                 3.26 (m, 3H)              132  CH.sub.3                                                                             H   H  CH.sub.2 CH.sub.3                                                                    H    H     CH.sub. 2 (2-FPh)                                                                       oil, endo                                                                               4.7 (d, 1H),                                                                   4.5 (d, 1H),                                                                   3.87 (d + dd, 2H),                                                             3.43 (dq, 2H),                                                                 3.28 (d + m, 3H)          133  CH.sub.3                                                                             H   H  CH.sub.2 CH.sub.3                                                                    H    H     CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, endo                                                                               4.63 (d, 1H),                                                                  4.40 (d, 1H),                                                                  3.83 (d + dd, 2H),                                                             3.42 (dq, 2H),                                                                 3.27 (d + m, 3H)          134  CH.sub.3                                                                             H   H  CH.sub.2 CH.sub.3                                                                    H    H     CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, endo                                                                               4.71 (d, 1H),                                                                  4.50 (d, 1H),                                                                  3.8 (d + dd, 2H),                                                              3.42 (dq, 2H),                                                                 3.27 (d + m, 3H)          135  CH.sub.3                                                                             H   H  CH.sub.2 CH.sub.3                                                                    H    H     CH.sub.2 (2-ClPh)                                                                       oil, endo                                                                               4.72 (d, 1H),                                                                  4.5 (d, 1H),                                                                   3.82 (d + dd, 2H),                                                             3.45 (dq, 2H),                                                                 3.3 (m, 3H)               136  CH.sub.3                                                                             H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-ClPh)                                                                       oil, endo                                                                               4.71 (d, 1H),                                                                  4.54 (d, 1H),                                                                  3.88 (m, 2H),                                                                  3.3 (m, 6H)               137  CH.sub.3                                                                             H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            oil, endo                                                                               4.83 (d, 1H),                                                                  4.72 (d, 1H),                                                                  3.9 (m, 2H),                                                                   3.33 (s, 3H),                                                                  3.33 (m, 1H),                                                                  3.23 (m, 2H)              138  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (Ph)                                                                           endo     4.65 (d + d, 2H),                                                     m.p. 78-80° C.                                                                   4.40 (d, 1H),                                                                  3.3 (t, 1H),                                                                   3.15 (s, 3H)              139  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2-FPh)                                                                        endo     4.65 (d + d, 2H),                                                     m.p. 84-86° C.                                                                   4.39 (d, 1H),                                                                  3.31 (t, 1H),                                                                  3.15 (s, 3H)              140  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2-ClPh)                                                                       endo     4.65 (d + d, 2H),                                                     m.p. 50-52° C.                                                                   4.42 (d, 1H),                                                                  3.38 (t, 1H),                                                                  3.16 (s, 3H)              141  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2,6-(F).sub.2 Ph)                                                             endo     4.66 (d + d, 2H),                                                     m.p. 102-104° C.                                                                 4.39 (d, 1H),                                                                  3.31 (t, 1H),                                                                  3.14 (s, 3H)              142  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2-(CH.sub.3)Ph)                                                               endo     4.6 (d + d, 2H),                                                      m.p. 49-50° C.                                                                   4.4 (d, 1H),                                                                   3.29 (t, 1H),                                                                  3.15 (s, 3H)              143  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            endo     4.82 (s, 2H),                                                         m.p. 100-101° C.                                                                 4.4 (d, 1H),                                                                   3.3 (t, 1H),                                                                   3.14 (s, 3H)              144  H     CH.sub.3                                                                           CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2,4-(F).sub.2 Ph)                                                             endo     4.6 (d + d, 2H),                                                      m.p. 102-103° C.                                                                 4.39 (d, 1H),                                                                  3.11 (t, 1H),                                                                  3.15 (s, 3H)              145  CH.sub.3                                                                             H   H  CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.64 (d, 1H),                                                                  4.46 (d, 1H),                                                                  3.50 (dd, 1H),                                                                 3.34 (s, 3H),                                                                  3.21 (dd, 1H)             146  CH.sub.3                                                                             H   H  CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2-F(Ph)                                                                       oil, endo                                                                               4.69 (d, 1H),                                                                  4.50 (d, 1H),                                                                  3.5 (dd, 1H),                                                                  3.4 (dd, 1H),                                                                  3.35 (s, 3H)                                                                   3.25 (dd, 1H)             147  CH.sub. 3                                                                            H   H  CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, endo                                                                               4.70 (d, 1H),                                                                  4.50 (d, 1H),                                                                  3.50 (dd, 1H),                                                                 3.40 (dd, 1H),                                                                 3.35 (s, 3H)                                                                   3.21 (d + d, 1H)          148  CH.sub.3                                                                             H   H  CH.sub.3                                                                             CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.2 (2-ClPh)                                                                       oil, endo                                                                               4.72 (d, 1H),                                                                  4.52 (d, 1H),                                                                  3.52 (dd, 1H),                                                                 3.39 (dd, 1H),                                                                 3.35 (s, 3H)                                                                   3.30 (dd, 1H)             149  CH.sub.3                                                                             H   H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.64 (d, 1H),                                                                  4.48 (d, 1H),                                                                  3.45 (dd, 1H),                                                                 3.34 (s, 3H)                                                                   3.34 (dd, 1H)                                                                  3.20 (dd, 1H)             150  CH.sub.3                                                                             H   H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.2 (2-FPh)                                                                        oil, endo                                                                               4.68 (d, 1H),                                                                  4.52 (d, 1H),                                                                  3.45 (dd, 1H),                                                                 3.34 (s + dd, 4H)                                                              3.24 (dd, 1H)             151  CH.sub.3                                                                             H   H  CH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                   CH.sub.2 CH.sub.3                                                                    CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, endo                                                                               4.7 (d, 1H),                                                                   4.5 (d, 1H),                                                                   3.45 (s + dd, 1H),                                                             3.24 (dd, 1H)             152  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (Ph)                                                                           oil, endo                                                                               4.65 (d, 1H),                                                                  4.40 (d, 1H),                                                                  3.9 (d, 1H),                                                                   3.78 (dd, 1H),                                                                 3.36 (dd, 2H),                                                                 3.33 (s, 3H),                                                                  3.24 (dd + dd, 2H)        153  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-FPh)                                                                        oil, endo                                                                               4.7 (d, 1H),                                                                   4.45 (d, 1H),                                                                  3.9 (d, 1H),                                                                   3.79 (dd, 1H),                                                                 3.4 (dd, 2H),                                                                  3.33 (s, 3H),                                                                  3.24 (dd + dd, 2H)        154  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,6-(F).sub.2 Ph)                                                             oil, endo                                                                               4.7 (d, 1H),                                                                   4.47 (d, 1H),                                                                  3.89 (d, 1H),                                                                  3.78 (dd, 1H),                                                                 3.39 (dd, 2H),                                                                 3.36 (s, 3H),                                                                  3.26 (dd + dd, 2H)        155  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-ClPh)                                                                       oil, endo                                                                               4.75 (d, 1H),                                                                  4.46 (d, 1H),                                                                  3.91 (d, 1H),                                                                  3.8 (dd, 1H),                                                                  3.44 (dd, 2H),                                                                 3.34 (s, 3H),                                                                  3.25 (dd + dd, 2H)        156  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2,6-(Cl).sub.2 Ph)                                                            endo     4.82 (d, 1H),                                                         m.p. 77-77.5° C.                                                                 4.69 (d, 1H),                                                                  3.89 (d, 1H),                                                                  3.79 (dd, 1H),                                                                 3.4 (dd, 2H),                                                                  3.34 (s, 3H),                                                                  3.24 (s + s, 2H)          157  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, endo                                                                               4.85 (d, 1H),                                                                  4.38 (d, 1H),                                                                  3.9 (d, 1H),                                                                   3.8 (dd, 1H),                                                                  3.39 (dd, 2H),                                                                 3.34 (s, 3H),                                                                  3.22 (m, 2H)              158  CH.sub.2 CH.sub.3                                                                    H   H  CH.sub.3                                                                             H    H     CH.sub.2 (2-BrPh)                                                                       oil, endo                                                                               4.71 (d, 1H),                                                                  4.41 (d, 1H),                                                                  3.92 (d, 1H),                                                                  3.80 (dd, 1H),                                                                 3.46 (dd, 2H),                                                                 3.33 (s, 3H),                                                                  3.24 (m,                  __________________________________________________________________________                                                          2H)                  

                                      TABLE 13                                     __________________________________________________________________________      ##STR31##                                                                                                               Physical                                                                       Properties                                                                     Configuration                                                                             Partial                   Cmpd  R.sup.1                                                                             R.sup.3                                                                            R.sup.4                                                                            R.sup.5                                                                             R.sup.9                                                                            R.sup.10                                                                            Q        Ratio (I:(18))                                                                            NMR                       __________________________________________________________________________                                                          (δ)                 159   CH.sub.3                                                                            H   H   CH.sub.3                                                                            H   H    CH.sub.2 (Ph)                                                                           oil, endo  4.64 (d, 1H),                                                                  4.44 (d, 1H),                                                                  3.88 (d, 1H),                                                                  3.82 (dd, 1H),                                                                 3.32 (s, 3H),                                                                  3.2 (m, 3H)               160   CH.sub.3                                                                            H   H   CH.sub.3                                                                            H   H    CH.sub.2 P(2-FPh)                                                                       oil, endo  4.7 (d, 1H),                                                                   4.52 (d, 1H),                                                                  4.88 (d, 1H),                                                                  4.81 (dd, 1H),                                                                 3.33 (s, 3H),                                                                  3.3-3.2 (m, 3H)           161   CH.sub.3                                                                            H   H   CH.sub.3                                                                            H   H    CH.sub.2 P(2,6-(F).sub.2 Ph)                                                            oil, endo  4.7 (d, 1H),                                                                   4.5 (d, 1H),                                                                   3.85 (d, 1H),                                                                  3.8 (dd, 1H),                                                                  3.33 (s, 3H),                                                                  3.22 (m,                  __________________________________________________________________________                                                          3H)                  

                                      TABLE 14                                     __________________________________________________________________________      ##STR32##                                                                                                             Physical                                                                       Properties  Partial                    Cmpd  R.sup.1                                                                            R.sup.3                                                                            R.sup.4                                                                            R.sup.5                                                                             R.sup.9                                                                             R.sup.10                                                                            Q      Configuration                                                                              NMR                        __________________________________________________________________________                                                         (δ)                  162   H   H   H   CH.sub.3                                                                            CH.sub.3                                                                            H    CH.sub.2 (Ph)                                                                         oil, endo   4.62 (d, 1H),                                                                  4.52 (d, 1H),                                                                  4.35 (s, 1H),                                                                  4.09 (q, 1H),                                                                  3.5 (t, 1H),                                                                   3.4 (dd, 1H),                                                                  3.32 (dd, 1H),                                                                 3.36 (s, 3H)               163   H   H   H   CH.sub.3                                                                            CH.sub.3                                                                            H    CH.sub.2 (2-FPh)                                                                      oil, endo   4.62 (d + d, 2H),                                                              4.36 (s, 1H),                                                                  4.06 (q, 1H),                                                                  3.5 (t, 1H),                                                                   3.4 (dd, 1H),                                                                  3.36 (s, 3H),                                                                  3.35 (m, 1H)               164   H   H   H   CH.sub.3                                                                            CH.sub.3                                                                            H    CH.sub.2 (Ph)                                                                         oil, endo   4.62 (d, 2H),                                                                  4.54 (d, 1H),                                                                  4.23 (s + m, 2H),                                                              3.4 (d, 2H),                                                                   3.35 (s, 3H),                                                                  3.34 (m, 1H)               165   H   H   H   CH.sub.3                                                                            CH.sub.3                                                                            H    CH.sub.2 (2-FPh)                                                                      oil, endo   4.63 (d + d, 2H),                                                              4.24 (m + s, 2H),                                                              3.41 (d, 2H),                                                                  3.35 (s, 3H),                                                                  3.34 (m,                   __________________________________________________________________________                                                         1H)                   

                                      TABLE 15                                     __________________________________________________________________________      ##STR33##                                                                                                             Physical                                                                       Properties                                                                               Partial                      Cmpd R.sup.1                                                                             R.sup.3                                                                           R.sup.4                                                                            R.sup.5                                                                              R.sup.9                                                                            R.sup.10                                                                           Q        Configuration                                                                            NMR (δ)                __________________________________________________________________________     166  CH.sub.3                                                                            H  H   CH.sub.2 CH.sub.3                                                                    H   H   CH.sub.2 (Ph)                                                                           oil, endo 4.55 (s, 2H),                                                                  4.0 (d + d + dd, 3H),                                                          3.68 (t, 1H),                                                                  3.4 (m, 4H),                                                                   3.38 (dd, 1H)                167  CH.sub.3                                                                            H  H   CH.sub.2 CH.sub.3                                                                    H   H   CH.sub.2 (2-FPh)                                                                        oil, endo 4.6 (d +  d, 2H),                                                              4.07 (t + d, 2H),                                                              3.9 (d, 1H),                                                                   3.69 (dd, 1H),                                                                 3.4 (m, 4H),                                                                   3.4 (dd, 1H)                 168  CH.sub.3                                                                            H  H   CH.sub.2 CH.sub.3                                                                    H   H   CH.sub.2 (2-(CH.sub.3)Ph)                                                               oil, endo 4.55 (d + d, 2H),                                                              4.05 (d, 1H),                                                                  4.04 (dd, 1H),                                                                 3.9 (d, 1H),                                                                   3.69 (t, 1H),                                                                  3.49 (m, 4H),                                                                  3.35 (dd,                    __________________________________________________________________________                                                       1H)                     

                                      TABLE 16                                     __________________________________________________________________________      ##STR34##                                                                                                               Physical                                                                       Properties Partial                   Cmpd R.sup.1                                                                            R.sup.2                                                                            R.sup.3                                                                               R.sup.4                                                                              R.sup.5  Q      Configuration                                                                             NMR                       __________________________________________________________________________                                                          (δ)                 169  H   H   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                    CH.sub.2 (Ph)                                                                           CH.sub.2 (Ph)                                                                         oil, endo  4.67 (m, 4H),                                                                  4.51 (s + d, 2H),                                                              3.65 (d + d, 2H),                                                              3.13 (s, 3H)              170  H   H   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                    CH.sub.2 (2-FPh)                                                                        CH.sub.2 (2-FPh)                                                                      oil, endo  4.70 (d, 4H),                                                                  4.52 (s + d, 2H),                                                              3.7 (d + d, 2H),                                                               3.15 (s, 3H)              171  H   H   CH.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                    CH.sub.3 CH.sub.2 (2-FPh)                                                                      oil, endo  4.71 (brs, 2H),                                                                4.45 (s + d, 2H),                                                              3.66 (d, 1H),                                                                  3.52 (d, 1H),                                                                  3.42 (s, 3H),                                                                  3.15 (s,                  __________________________________________________________________________                                                          3H)                  

TEST A

Seeds of barley (Hordeum vulgare), barnyardgrass (Echinochloa crus-galli), cheatgrass (Bromus secalinum), cocklebur (Xanthium pensylvanicum), corn (Zea mays), cotton (Gossypium hirsutum), crabgrass (Digitaria spp.), giant foxtail (Setaria faberi), morningglory (Ipomoea spp.), rice (Oryza sativa), sorghum (Sorghum bicolor), soybean (Glycine max), sugar beet (Beta vulgaris), velvetleaf (Abutilon theophrasti), wheat (Triticum aestivum), and wild oat (Avena fatua) and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crops and weed species were also treated with postemergence applications of test chemicals. Plats ranged in height from two to eighteen cm (two to three leaf stage) for postemergence treatments. Treated plants and untreated controls were maintained in a greenhouse for approximately sixteen days, after which all species were compared to untreated controls and visually evaluated. Plant response ratings, summarized in Table A, are based on a scale of 0 to 10 where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

    TABLE A        Barnyard- Cheat-    Crab- Giant Morning-     Sugar Velvet-  Wild      COMPOUND Rate Barley grass grass Cocklebur Corn Cotton grass foxtail      glory Nutsedge Rice Sorghum Soybean beet leaf Wheat Oat        POSTEMERGENCE 43 (2000 g/ha) 0 0 0 3 00 3 0 0 0 0 0 0 0 0 0 0 44      00000000000000000 45  000000000--0000000 46  000000--0000000000 47      0000003 0000000000 1 (400 g/ha)0 6 0 2 0 8 0 0 0 0 1 0 3 0 1 0 0 2  0 0      0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 3 0 0 0 2 0 0 0 000001 0000 4  000 1 00000      9 0000000 5  0 9 0 4 5 0 8 8 0 0 0 0 3 0 0 0 0 6  0 9 0 1 1 0 2 4 0 0 0      0 0 2 0 0 0 7  00000000000000000 8 2 9 0 3 5 2 9 9 0 0 6 0 2 0 0 0 0 9      0 3 0 2 0 0 3 2 0 0 0 0 0 0000 10 0 2 0 3 0 0000000006 00 11 0 3 0 2 0 0      3 0000000000 12 0 2 0 1 00000000002 0 0 13  0 6 0 2 2 0 2 0 0 -- 0 0 0 1      0 0 0 14  0 0 3 0 0 0 0 2 0 -- 0 0 0 2 0 0 0 16  000000 -- 4 000000000      18 (200 g/ha) 0 00 1 000 2 000000000 21  000 1 0000000000000 22 000      10000000000000 23 0 2 0 1 0 0 3 0 0 -- 0 0 0 0 0 0 0 25 6 9 0 2 7 0 6 2      0 -- 0 0 1 0 0 7 0 26  0 0 0 3 0 0 4 0 0 0 0 0 0 0 1 0 0 27  0 0 0 4 0 0      0 0 1 7 0 0 0 0 -- 0 0 28 0 3 0 1 4 0 3 0 0 0 0 0 2 2 8 0 0 29  0 0 0 1      0 0 0 0 0 8 0 0 0 0 0 0 0 30 0 0 0 1 0 0 0 0 0 0 0 0 0 0 8 0 0 31 0 6 2      1 2 0 8 9 0 9 0 0 1 2 0 0 0 32  0 9 3 6 5 2 0 9 1 0 0 0 0 4 3 0 0 33  0      0 0 4 0 0 0 0 0 -- 0 0 1 0 7 0 0 35  0 0 0 2 0 0 0 0 0 0 0000000 36  0 0      0 1 0 4 3 0 0 -- 0 0 0 0 2 0 0 37  0 5 0 1 0 0 0 8 0 0 2 0 0 0 3 0 0 40      0 0 0 1 00000-- 0000000 41  00000000000000000 42  00000000000000000 43      00000000000000000 44  00000000000000000 45  00000000000000000 46      00000000000000000 47  00000000000000000 48 00010000000000000 49  0 0 0 1      3 0 7 2 0 -- 0 0 0 0 1 0 0 50  0 2 4 2 0 1 -- 0 0 -- 0 0 2 4 1 0 0 51  0      0 0 1 0 0 -- 1 0 -- 0 0 0 0 5 0 0 52  0 0 0 1 0 0 -- 0 0 -- 0 0 0 0 1 0      0 53  0 3 0 0 2 0 0 0 0 6 0 0 0 3 0 0 0 54  0 0 0 1 0 0 0 0 0 -- 0 0 0 0      1 0 0 55  000 1 000 2 0 -- 0000000 56  0 6 2 1 0 1 0 0 0 0 0 0 0 5 5 0 0      57  0 0 0 2 0 3 0 0 0 0 0 0 1 3 -- 0 0 58  0 2 0 1 0 0 3 0 0 -- 0 0 0 3      1 0 0 59  0 0 0 1 0 0 8 0 0 4 0 5 0 4 1 0 0 60  000 3 00 4 0000 3 1 2 6      0 0 61  0  0 2 000 2 00001 2 1 00 62  0 3 0 1 0 0 2 0000 3 1 4 2 0 0 63      0 1 0 1 0 3 00000000 3 0 0 64 000 3 0 3 00000000 3 00 65 00000 2      000000002 00 66  000 1 0000000000 2 00 67  000 1 0000000000 2 00 68      0001 0 6 00000000 1 00 69 00000 5 00000000 1 00 70 0 2 0 1 0000000000000      71 0 2 0 1 00000 -- 0000 -- 00 72 000 1 0000000000 -- 00 73  000 2      0000000000000 74  000 1 0000000000000 75  000 1 0000000000000 76  000 1      0000000000000 77  000 1 0000000000000 78  0 3 00000 5 000000000 79  000      1 0000000000000 80 0 3 0 1 0000000000000 81 0 3 6 1 000000 4 0 0 2 -- 0      3 82  000000000 -- 0000000 83  00000000000000000 84  000 5 0000000000 2      00 85  00000000000000000 86  0 2 000000000000 -- 00 87  00000000000000      -- 00 88  000 1 00 2 0000000000 89  000 1 00 2 0000000 -- 00 90  000 2      000 2 0 -- 0000000 92  000 1 2 000000000 -- 00 93  0 8 0 2 2 -- 2 4 1 --      2 0 2 1 0 0 0 94  0 8 0 2 2 0 2 2 0 4 2 0 0 0 -- 0 0 95  0 0 0 4 0 7 0 0      1 0 0 0 1 0 3 0 0 96  0 0 0 2 0 0 2 0 0 0 0 0 3 2 0 0 0 97  0 7 0 3 0 0      0 7 0 0 0 0 1 4 1 0 0 98  0 0 0 1 0 0 1 0 0 0 0 0 0 0 2 0 0 99  0 0 0 1      0000000000000 100  000 -- 0000000000000 101  0 3 0 1 0 0 2 0 0 -- 0 0 1      0 2 0 0 102  0 4 0 1 0 0 3 5 0 0 5 3 1 0000 103  0 4 0 1 0 0 0 3 0 0 0 0      3 0 1 0 0 104  000 1 0000000000000 107  0 5 0 1 6 0 0 4 000000000 111  0      0 0 1 0000000000000 112  0 7 0 1 1 000000000000 113  000 1 0000000000000      114  000 1 0000000000000 115  0 1 0 1 00000000 3 0 1 0 0 116  00000000000      000000 117 000 1 0000000000000 118  8 9 9 1 9 2 9 9 2 9 9 7 9 6 7 6 5      119  6 9 9 -- 8 0 9 9 1 8 8 0 2 0 7 2 2 120  9 9 9 1 9 3 9 9 0 -- 9 7 6      3 7 9 8 121  0 0 0 1 0 2 00000000000 122 0000000000 -- 000000 123  000 1      00000-- 0 -- 00000 124  000 1 00000 -- 0000 3 0 0 125 0 1 0 1 00000 --      0000000 126  0 1 00000 2 0 -- 0000000 127  000000000 -- 0000 1 0 0 128      000000000 -- 0000000 129  000 1 00000 -- 0000000 130  9 9 9 2 9 0 9 9 2      -- 9 0 1 9 7 9 0 131  0 3 0 1 7 0 0 9 0 -- 8 0 4 2 5 0 0 132  0 9 0 1 7      1 2 9 1 0 6 4 4 0 4 0 0 133  0 9 3 1 4 2 7 9 0 6 8 0 2 0 3 0 0 134  3 10       0 1 8 2 8 9 1 -- 9 7 3 2 6 6 0 135  0 1 0 1 2 1 3 4 1 -- 2 0 4 0 3 0 0      136  0 9 0 2 7 1 2 0 1 -- 0 1 5 2 5 0 0 137  0 9 0 2 2 0 2 9 0 0 1 0 3 0      5 0 0 138  000000 3 0000000000 139  00000000000000000 140  00000000000000      000 141  00000000000000000 142  00000000000000000 145  0 9 0 1 3 0 0 0 0      0 4 0 0 0 3 0 0 146  3 8 0 1 6 0 0 2 0 0 0 0 1 0 2 0 0 147  7 8 0 1 5 1      6 9 0 0 9 0 0 0 1 2 0 148  0 1 0 1 0 0 1 2 0 0 0 0 0 0 1 00 149  00 3 2      1 000000000 3 0 0 150  0 2 0 2 0000000000000 151  3 2 0 7 2 0 0 3 0 0 0      0 0 0 2 0 0 152  2 9 8 0 8 8 9 9 0 3 9 6 8 3 7 2 0 153  6 9 6 2 8 2 9 9      0 6 9 5 5 0 3 7 0 154  6 9 9 2 9 6 9 9 0 9 9 0 2 0 8 6 3 155  0 9 0 1 2      5 8 9 0 7 3 3 3 1 6 0 0 156  0 3 0 1 0 4 4 3 0 0 0 3 2 0 6 0 0 157  3 9      0 1 8 3 9 8 0 0 2 0 2 0 8 7 0 158  0 8 0 1 0 3 2 7 0 0 0 0 2 0 4 0 0 166       0 0 0 1 0 000000000000 167  0 1 0 1 0 0 0 2 0 0 0 0 0 0 2 0 0 168  0 2      0 1 0000000000000 1       (100 g/ha) 000100000000 1 0000 2  000 1 0000000000000 3  000 1 000000000      0000 4  000000000-- 0000000 5  0 3 0 3 0000000000000 6  00000000000000000       7  00000000000000000 8  0 5 0 2 0 0 2 4 000000000 9  000 -- 000000000000      0 10  000 2 0000000000000 11  000 2 0000000000000 12  000 1 0000000000000       13  00000000000000000 14  00000000000000000 15  000000 -- 2 0 --      0000000 16  00000000000000000 17  0 -- 0 1 0000000000000 34 000 3 00 3 2      000000 1 00 40  000000000 -- 0000000 41  000000000 -- 0000000 42      00000000000000000 105  0000000 -- 0 -- 0000000 106  00000000000000000 18       (50 g/ha) 000 1 0000000000000 21  000 1 0000000000000 22  00000000000000      000 23  000 1 0000000000000 25  0 2 000000000000000 26  000 2 0000000000      1 00 27  000000000 8 0000000 28  000 2 0000000000000 29  0000000000000000      0 30  00000000000000000 31  000 1 0000000000000 32  000 1 0000000000000      33  0 0 0 1 00000-- 0000000 35  000 -- 00000 -- 0000000 36 00000000000000      000 37 00000000000000000 40 00000000000000000 41 00000000000000000 42      00000000000000000 43  00000000000000000 44  00000000000000000 45      00000000000000000 46  00000000000000000 47  00000000000000000 48      00000000000000000 49  0 0 0 0 0 0 2 0 0 -- 0 0 0 0 0 0 0 50  0 0 0 1 0 0      -- 0 0 0 0 0 0 0 1 0 0 51  00000000000000000 52  000000--0000000000 53      0 000000000000-- 000 54  00000000000000000 55  000000000 -- 0000000 56      0 2 0 1 0 1 00000000000 57  0 0 0 2 0 2 0 0 0 -- 0 0 0 0 -- 0 0 58  0 0      0 1 0 0 -- 0 0 -- 0 0 0 0 -- 0 0 59  0 0 0 0 0 0 0 6 0 0 0 0 0 2 0 0 0      60  000000 2 0000000000 61  0 0 0 2 00000000001 00 62  0 0 0 1 0 0 -- 0      0 -- 0 0 0 0 0 0 0 63  00000000000000000 64  000000000000001 00 65      000000000000001 00 66  00000000000000000 67  00000000000000000 68      00000000000000100 69  00000000000000100 70  00000000000000 -- 00 71      00000000000000 -- 00 72  000 1 00000-- 0000000 73  000 1 0000000000000      74  000 1 0000000000000 75  000 1 0000000000000 76  000 1 0000000000000      77  000 1 0000000000000 78  000 0 0000000000000 79  0 0 0 1 0000000000000       80  000000000 -- 0000000 81  00000000000000000 82  00000000000000000 83       00000000000000000 84 00000000000000--00 85  00000000000000000 86      00000000000000000 87  00000000000000000 88  0 0 0 1 0 000000000 -- 0 0      89  0 0 0 1 0000000000000 90  000000000 -- 0000000 92  0 0 0 -- 000000000      0000 93  000 1 0000000000000 94  0 2 0 -- 0 0 2 0 0 4 0000000 95  000 3      0000000000 2 00 96  000 2 0000000000000 97  000 -- 00000000001 00 98      000 1 0000000000000 99  000 1 0000000000000 100  000 1 0000000000000 101       000 1 0000000000000 102  000 0 0000000000000 103  000 1 0000000000000      104  000 0 0000000000000 107 000 1 2000000000000 108  0 0 0 2 0 0 0 2 0      00000000 109  0001 0000000000000 110  000 1 0000000000000 111  0000000000      0000000 112  00000000000000000 113  00000000000000000 114  00010000000000      000 115  00010000000000000 116  00000000000000000 117  00010000000000000      118  0 9 2 1 7 0 7 9 0 -- 2 3 0 4 3 2 2 119  0 3 3 2 0 0 9 9 0 5 0 0 0 0      1 0 0 120  5 8 8 1 9 0 9 9 0 0 8 7 2 0 6 7 0 121  00000000000000000 122      0 00000000 -- 0000000 123  0 00000000 -- 0000000 124  0 00000000 --      0000000 125  0 00000000 -- 0000000 126  0 00002000 -- 0000000 127  0      00000000 -- 0000000 128  0 00000000 -- 0000000 129 0 00000000 -- 0000000      130  0 6 0 1 0 0 2 4 0 -- 0 0 1 0 0 0 0 131  0 0 0 0 0 0 0 3 0 0 0 0 2 0      0 0 0 132  0 0 0 1 0 0 0 6 0 0 0 0 1 0 1 0 0 133  0 1 0 1 0 0 0 3 0 0 0      0 0 0 1 0 0 134  0 1 0 1 0 0 0 5 1 -- 2 0 1 0 0 0 0 135  0 0 0 1 0 0 0 2      0 -- 1 0 2 0 1 0 0 136  00000000000000000 137  0 3 0000000000001 00 138      00000000000000000 139  00000000000000000 140  000000000-- 0000000 141      00000000000000000 142  00000000000000000 143  00000000000000000 144      00000000000000000 145  00000000000000000 146  01000000000000000 147  000      1 002 2000000000 148  00100000000000000 149  00000000000000000 150      0200000000000--000 151  00000000000000000 152  0 9 0 0 2 0 3 9 0 0 3 3 3      0 2 0 0 153  0 8 0 1 6 0 3 9 0 3 8 0 2 0 2 0 0 154  0 9 4 1 4 0 7 9 0 3      8 0 0 0 2 0 0 155  0 4 0 1 0 0 0 2 0 0 0 2 1 0 3 0 0 156  0 0 0 1 0 0 2      0 0 0 0 0 0 0 2 0 0 157  0 6 0 2 0 3 0 8 0 0 0 0 0 0 2 0 0 158  0 2 0 1      0 0 0 0 0 -- 0 0 0 0 2 0 0 166  0 0000000000000000 167 00010000000000000      168 000 1 0000000000000 PREEMERGENCE 43 (2000 g/ha) 0000 004 50 --0000000       44  0 2 0 0 0 0 0 2 0 00000000 45  0 2 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 46       00000005 0 -- 0000000 47  000000 2 3 000000000 1  (400 g/ha) 0 10 0 0 0      0 9 9 0 0 0 0 0 0 1 0 0 2  3 10  0 0 3 0 9 9 0 0 0 9 0 1 1 0 0 3  0 9 0      0 0 0 7 8 0 0 0 0 0 0 1 0 0 4  2 10  0 0 3 0 9 9 0 0 0 8 1 0 1 0 0 5  5      10  6 3 6 2 9 9 0 0 0 7 6 2 7 2 3 6  0 9 3 4 4 0 6 6 0 4 0 0 0 4 0 0 2 7       00000000000000000 8  2 10  4 5 4 3 9 9 0 2 0 5 3 3 6 3 0 9  0 7 0 0 0 0      7 7 0 0 0 0 2 0 2 0 0 10 0 8 0 0 0 0 8 7 5 0 0 0 0 0 5 0 0 11 0 9 2 0 0      0 7 8 0 0 0 0 0 0 2 0 2 12  0 8 3 5 0 0 7 7 0 0 0 0 0 0 6 0 0 13  0 8 0      0 0 0 0 2 0 0 0 0 0 0 0 0 0 14  000000 3 0000000000 16  0 7 2 -- 2 0 0 5      0 0 0 6 0 0 1 0 0 18  (200 g/ha) 0 2 0 0 0 0 2 2 0 0 0 0 0 0 2 0 0 21  0      9 3 0 0 0 5 9 0 0 0 0 0 0 2 0 0 22  2 9 2 0 0 0 5 8 0 0 0 0 0 0 1 0 0 23       0 9 2 0 0 0 6 6 0 0 0 0 0 0 1 0 0 25  3 9 7 0 3 5 8 9 0 0 4 8 0 3 5 3 0      26  0 0 0 3 0 0 7 6 0 0 0 0 0 0 0 0 0 27  0 9 0 -- 0 0 0 8 0 3 0 0 0 0 2      0 0 28  0 10  3 7 1 0 8 9 2 0 0 8 2 3 4 0 0 29  0 9 0 8 2 0 8 5 0 0 0 0      0 0 8 0 0 30 0 6 0 -- 0 0 2 6 0 0 0 0 0 2 0 0 0 31  1 9 6 0 2 0 0 9 0 0      0 2 0 0 0 0 0 32  0 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2 4 2 6 6 0 2 156  0 10  2 0 0 0 9 9      00000 3 7 0 0 157  3 10  6 0 5 2 9 10  0 5 3 2 3 7 7 2 2 158  0 10  2 0      0 0 9 10  0 0 3 3 0 2 6 0 0 166  0 9 0 0 1 0 9 9 00 2 2 1 2 000 167  0      10  2 0 1 0 9 10  0 0 5 2 1 4 1 0 0 168  0 7 0000 5 7 000000 2 00 1      (100 g/ha) 0 6 0 -- 0 0 2 6 0 0 0000000 2  0 9 0000 5 9 000000000 3  0      0000000000000000 4  0 9 0 -- 0 0 9 9000000000 5  0 9 0 3 0 0 8 8 0 0 0 0      0 0 5 0 0 6  0 8 2 0 0 0 5 6 000000000 7  00000000000000000 8  0 9 3 1 2      0 6 8 0 0 0 0 0 2 2 0 0 9  00000000000000000 10  0 2 0000 5 2 000000000      11  0 2 0000 2 2 000000000 12  0 2 0 5 0 0 4 4 0 -- 0000000 13  000000000      00000000 14  00000000000000000 15  02 0 0 0 0 5 5000000000 16  00000003      000000000 17  0 5 00000 5 000000 1 00 34  0 8 0000 8 8 000000 1 00 40      00000000000000000 41  00000000000000000 42  00000000000000000 105  00 2      000000 -- 0000 2 00 106  00000000000000000 18       (50 g/ha) 00000000000000000 21 000000 3 2 0 -- 0000000 22  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000000000

TEST B

Seeds of barley (Hordeum vulgare), barnyardgrass (Echinochloa crus-galli), blackgrass (Alopecurus myosuroides), cheatgrass (Bromus secalinus), chickweed (Stellaria media), cocklebur (Xanthium pensylvanicum), corn (Zea mays), cotton (Gossypium hirsutum), crabgrass (Digitaria spp.), Galium (Galium aparine), giant foxtail (Setaria faberii), lambsquarters (Chenopodium album), morningglory (Ipomea hederacea), rape (Brassica napus), rice (Oryza sativa), sorghum (Sorghum bicolor), soybean (Glycine max), sugar beet (Beta vulgaris), velvetleaf (Abutilon theophrasti), wheat (Triticum aestivum), wild buckwheat (Polygonum convolvulus), and wild oat (Avena fatua) and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were also treated with postemergence applications of test chemicals. Plants ranged in height from two to eighteen cm (one to four leaf stage) for postemergence treatments. Treated plants and untreated controls were maintained in a greenhouse for approximately fifteen to twenty days, after which all treated plants were compared to untreated controls and visually evaluated. Plant response ratings, summarized in Table B, are based on a scale of 0 to 10 where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

    TABLE B          Barn-          Lambs- Morn-         Wild-   COM- Bar- yard- Black-      Cheat- Chick- Cockle-  Cot- Crab- Gal- Giant quar- ing- Nut-   Sor- Soy-      Sugar Velvet- buck- Wild Rate POUND ley grass grass grass weed bur Corn      ton grass ium foxtail ters glory sedge Rape Rice ghum bean beet leaf      Wheat wheat oat        POSTEMERGENCE (400 169 0 0 0 0 0 1 0 1 1 0 0 3 1 0 0 1 2 2 0 1 0 0 0      g/ha) 170 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (200 162 0 0 0 0      0 2 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 g/ha) 163 0 0 0 0 2 0 0 0 0 0 0 0      0 0 0 0 0 0 2 0 0 0 0  164 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0       165 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0  171 7 10  5 5 5 8 9      2 9 2 9 2 2 9 5 9 5 7 5 7 8 4 4 (100 169 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0      0 0 0 0 0 0 g/ha) 170 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (50      162 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 g/ha) 163 0 0 0 0 0 0      0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0  164 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0      0 2 0 0 0 0  165 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0  171 0 9      0 1 0 4 7 2 5 0 5 0 2 2 0 9 2 4 0 5 0 0 0 PREEMERGENCE (400 169 0 0 0 0      0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 g/ha) 170 0 0 0 0 0 0 0 0 0 0 0 0      0 0 0 0 0 0 0 0 0 0 0 (200 162 2 1 3 2 2 0 1 0 2 0 3 0 0 0 0 0 0 0 0 0 0      0 g/ha) 163 0 0 2 2 6 0 0 0 0 0 3 2 0 0 2 0 0 0 3 0 0 0  164 0 0 3 2 0 0      0 0 0 0 2 -- 0 0 0 0 0 0 2 0 2 0 2  165 3 0 2 0 10  -- 0 0 0 0 0 0 0 0 0      0 0 0 2 0 0 2 2  171 0 10  10  10  10  5 7 7 9 10  9 10  4 0 7 5 1 8 9 8      1 10  9 (100 169 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 g/ha) 170      0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (50 162 0 0 2 2 0 0 0 0 0      0 0 0 0 0 0 0 0 0 0 0 0 0 0 g/ha) 163 0 0 2 0 5 0 0 0 0 0 0 0 0 0 0 0 0      0 2 0 0 0 0  164 0 0 2 0 0 -- 0 0 0 0 0 -- 0 0 0 0 0 0 2 0 0 0 0  165 0      0 2 0 0 -- 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0  171 0 9 5 2 5 -- 3 2 10  2      9 1 2 -- 1 2 0 2 0 4 0 0 0

TEST C

Seeds of barley (Hordeum vulgare), barnyardgrass (Echinochloa crus-galli), blackgrass (Alopecurus myosuroides), chickweed (Stellaria media), cocklebur (Xanthium pensylvanicum), corn (Zea mays), cotton (Gossypium hirsutum), crabgrass (Digitaria spp.), downy brome (Bromus tectorum), giant foxtail (Setaria faberii), green foxtail (Setaria viridis), jimsonweed (Datura stramonium), johnsongrass (Sorghum halepense), lambsquarters (Chenopodium album), morningglory (Ipomea spp.), rape (Brassica napus), rice (Oryza sativa), sicklepod (Cassia obtusifolia), soybean (Glycine max), sugar beet (Beta vulgaris), teaweed (Sida spinosa), velvetleaf (Abutilon theophrasti), wheat (Triticum aestivum), wild buckwheat (Polygonum convolvulus), and wild oat (Avena fatua) and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were also treated with postemergence applications of test chemicals. Plants ranged in height from two to eighteen cm (two to three leaf stage) for postemergence treatments. Treated plants and untreated controls were maintained in a greenhouse for approximately 24 days, after which all treated plants were compared to untreated controls and visually evaluated. Plant response ratings, summarized in Table C, are reported on a 0 to 10 scale where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

                                      TABLE C                                      __________________________________________________________________________                       Barnyard-                                                    Rate  COMPOUND                                                                               Barley                                                                             grass Blackgrass                                                                           Chickweed                                                                            Cocklebur                                                                            Corn                                                                              Cotton                                                                             Crabgrass                                                                            Downy                   __________________________________________________________________________                                                            brome                   POSTMERGENCE                                                                   (500 g/ha)                                                                           32      0   10    0     0     0     0  0   5     0                             34      0   7     0     0     0     0  0   --    0                             93      0   7     4     0     3     3  0   0     4                       (250 g/ha)                                                                            2      0   6     0     0     0     0  0   5     0                             25      0   8     3     0     6     0  0   0     0                             32      0   10    0     0     0     0  0   0     0                             34      0   7     0     0     0     0  0   0     0                             93      0   5     3     0     0     0  0   0     3                             94      0   2     3     0     5     0  0   0     0                             102     0   8     7     0     0     0  0   4     0                             118     0   10    8     7     0     0  0   2     1                             120     --  10    10    6     2     1  0   9     4                             130     5   10    9     7     0     0  0   9     8                             131     0   10    6     4     --    2  0   3     3                             132     3   8     6     4     --    0  2   6     4                             133     0   7     4     4     0     0  4   0     3                             134     2   10    6     5     4     0  0   3     3                             135     0   8     4     3     --    0  0   4     0                       (125 g/ha)                                                                            2      0   2     0     0     0     0  0   0     0                             25      0   4     0     0     5     0  --  0     0                             32      0   4     0     0     0     0  0   0     0                             34      0   7     0     0     0     0  0   0     0                             94      0   0     0     0     0     0  0   0     0                             102     0   6     3     0     --    0  0                                       118     0   10    0     5     0     0  0   2     0                             119     5   9     9     6     0     0  1   5     7                             120     9   10    9     6     1     0  0   9     4                             130     0   9     9     7     --    0  0   0     3                             131     0   5     4     4     --    0  0   0     0                             132     0   7     3     3     0     0  2   3     0                             133     0   4     3     4     0     0  3   0     0                             134     0   8     4     4     0     0  0   0     0                             135     0   7     3     0     --    0  0   3     0                       (62 g/ha)                                                                            32      0   0     0     0     0     0  0   0     0                             34      0   3     0     0     0     0  0   0     0                             94      0   0     0     0     0     0  0   0     0                             102     0   0     0     0     --    -- 0   0     0                             118     0   9     0     0     0     0  0   0     0                             120     1   10    4     3     0     0  0   7     0                             130     0   0     0     3     0     0  0   0     0                             131     0   5     0     3     --    0  0   0     0                             132     0   5     2     0     0     0  0   0     0                             133     0   3     0     0     0     0  2   0     0                             134     0   7     3     3     0     0  0   0     0                             135     0   6     0     0     --    0  0   3     0                       (31 g/ha)                                                                            94      0   0     0     0     0     0  0   0     0                             102     0   0     0     0     --    0  0   0     0                             118     0   4     0     0     0     0  0   0     0                             120     0   10    0     0     0     0  0   0     0                             130     0   0     0     0     0     0  0   0     0                             131     0   3     0     0     0     0  0   0     0                             132     0   3     0     0     0     0  0   0     0                             133     0   0     0     0     0     0  0   0     0                             134     0   6     0     0     0     0  0   0     0                             135     0   4     0     0     --    0  0   0     0                       __________________________________________________________________________     Rate  COMPOUND                                                                               Giant foxtail                                                                         Green foxtail                                                                         Jimsonweed                                                                            Johnsongrass                                                                          Lambsquarters                                                                          Morningglory                                                                          Nutsedge              __________________________________________________________________________     (500 g/ha)                                                                           32      7      5      0      3      5       0      0                           34      5      0      7      0      --      0      3                           93      7      0      0      0      --      0      3                            2      0      0      0      0      7       0      0                           25      3      0      0      0      5       0      0                           32      3      0      0      0      3       0      0                           34      3      0      3      0      0       0      0                           93      4      0      0      0      --      0      0                           94      5      2      0      0      --      0      0                           102     5      0      0      3      0       3      0                           118     10     10     5      4      10      4      0                           120     10     10     0      6      --      0      0                           130     9      8      0      6      3       4      0                           131     6      0      0      0      8       0      0                           132     7      6      3      3      6       0      6                           133     6      0      0      0      8       3      0                           134     7      6      4      6      6       4      7                           135     6      3      2      6      6       2      5                     (125 g/ha)                                                                            2      0      0      0      0      5       0      0                           25      0      0      0      0      4       0      0                           32      0      0      0      0      0       0      0                           34      0      0      0      0      0       0      0                           94      2      0      0      0      --      0      0                           102     3      0      0      0      0       2      0                           118     7      9      0      4      5       0      --                          119     9      4      0      0      9       1      0                           120     10     10     0      --     8       0      0                           130     9      0      0      0      3       3      0                           131     6      0      0      0      5       0      0                           132     5      2      2      0      4       0      0                           133     4      0      0      0      6       0      0                           134     6      3      3      3      3       3      5                           135     5      0      0      3      5       0      5                     (62 g/ha)                                                                            32      0      0      0      0      0       0      0                           34      0      0      0      0      0       0      0                           94      0      0      --     0      0       0      0                           102     0      0      0      0      0       0      0                           118     5      8      0      0      0       0      0                           120     10     5      0      5      8       0      0                           130     0      0      0      0      2       0      0                           131     3      0      0      0      4       0      0                           132     3      0      0      0      0       0      0                           133     3      0      0      0      0       0      0                           134     5      0      3      2      0       3      3                           135     4      0      0      0      4       0      3                     (31 g/ha)                                                                            94      0      0      0      0      --      0      0                           102     0      0      0      0      0       0      0                           118     2      0      0      0      --      0      0                           120     8      3      0      0      2       0      0                           130     0      0      0      0      --      0      0                           131     0      0      0      0      3       0      0                           132     0      0      0      0      0       0      0                           133     0      0      0      0      0       0      0                           134     4      0      2      0      0       3      0                           135     3      0      0      0      0       0      0                     __________________________________________________________________________                                                         Wild                       Rate  COMPOUND                                                                               Rape                                                                              Rice                                                                              Sicklepod                                                                            Soybean                                                                             Sugar beet                                                                           Teaweed                                                                             Velvetleaf                                                                           Wheat                                                                              buckwheat                                                                            Wild                 __________________________________________________________________________                                                               oat                  (500 g/ha)                                                                           32      0  5  0     0    0     0    7     0   8     0                          34      7  0  --    0    5     0    6     0   6     3                          93      0  3  0     0    3     7    4     5   0     0                    (250 g/ha)                                                                            2      4  0  0     0    0     0    --    0   --    0                          25      0  0  2     2    --    0    --    0   3     0                          32      0  2  0     0    0     0    5     0   3     0                          34      3  0  0     0    3     0    5     0   5     0                          93      0  0  0     0    3     5    2     3   0     0                          94      0  0  0     0    4     0    --    0   0     0                          102     0  3  0     0    6     0    0     3   3     0                          118     0  9  0     3    2     6    3     0   10    3                          120     0  6  3     3    6     4    --    6   10    --                         130     0  2  0     0    0     0    0     5   9     7                          131     0  6  0     0    7     0    0     4   7     0                          132     2  6  0     0    6     5    5     0   9     0                          133     2  5  0     0    3     3    6     3   7     0                          134     0  7  0     2    6     0    4     4   7     0                          135     4  3  0     0    6     5    6     0   7     0                    (125 g/ha)                                                                            2      0  0  0     0    0     0    --    0   --    0                          25      0  0  2     0    5     0    5     0   0     0                          32      0  0  0     0    0     0    4     0   0     0                          34      0  0  0     0    0     0    0     0   0     0                          94      0  0  0     0    3     --   0     0   0     0                          102     0  0  0     0    4     0    0     2   0     0                          118     0  0  0     0    0     0    0     0   9     0                          119     0  3  3     0    6     2    6     7   9     7                          120     0  6  0     3    4     2    6     6   10    5                          130     0  0  0     0    0     0    0     3   7     3                          131     0  3  0     0    6     0    0     3   6     0                          132     0  5  0     0    3     3    2     0   6     0                          133     0  2  0     0    3     0    3     0   5     0                          134     0  6  0     2    3     0    3     3   7     0                          135     3  0  0     0    3     3    4     0   5     0                    (62 g/ha)                                                                            32      0  0  0     0    0     0    3     0   0     0                          34      0  0  0     0    0     0    0     0   0     0                          94      0  0  --    0    0     0    0     0   0     0                          102     0  0  0     0    3     0    0     0   0     0                          118     0  0  0     0    0     0    0     0   9     0                          120     0  6  0     2    0     2    5     0   2     0                          130     0  0  0     0    0     0    0     0   6     0                          131     0  0  0     0    3     0    0     0   3     0                          132     0  0  0     0    0     0    0     0   5     0                          133     0  0  0     0    3     0    0     0   3     0                          134     0  4  0     0    3     0    3     0   4     0                          135     0  0  0     0    3     0    3     0   0     0                    (31 g/ha)                                                                            94      0  0  0     0    0     0    0     0   0     0                          102     0  0  0     0    0     0    0     0   0     0                          118     0  0  0     0    0     0    0     0   6     0                          120     0  0  0     0    0     2    0     0   0     0                          130     0  0  0     0    0     0    0     0   3     0                          131     0  0  0     0    0     0    0     0   0     0                          132     0  0  0     0    0     0    0     0   4     0                          133     0  0  0     0    0     0    0     0   0     0                          134     0  3  0     0    3     0    3     0   4     0                          135     0  0  0     0    0     0    3     0   0     0                    __________________________________________________________________________     PREEMERGENCE                                                                                     Barnyard-                                                    Rate  COMPOUND                                                                               Barley                                                                             grass Blackgrass                                                                           Chickweed                                                                            Cocklebur                                                                            Corn                                                                              Cotton                                                                             Crabgrass                                                                            Downy                   __________________________________________________________________________                                                            brome                   (500 g/ha)                                                                           32      0   10    9     4     0     10 0   9     4                             34      0   10    5     0     --    8  0   9     0                             93      8   10    10    6     9     10 0   9     0                       (250 g/ha)                                                                            2      0   10    7     0     0     2  0   8     0                             25      0   10    10    6     7     3  0   9     2                             32      0   10    8     2     0     3  0   2     2                             34      0   10    5     0     0     0  0   8     0                             93      7   10    9     6     7     8  0   9     0                             94      3   10    7     4     10    0  3   10    4                             102     4   20    6     9     3     2  0   10    3                             118     7   10    7     7     4     10 3   10    5                             120     10  10    10    7     3     10 9   10    5                             130     5   10    7     8     6     4  5   10    4                             131     7   10    8     8     0     6  0   10    5                             132     6   10    7     7     10    5  2   10    6                             133     3   10    6     8     7     3  3   10    4                             134     7   10    10    9     3     8  4   10    8                             135     0   10    6     9     0     0  0   10    3                       (125 g/ha)                                                                            2      0   10    0     0     0     0  2   0                                   25      0   10    10    3     0     2  0   7     0                             32      0   10    6     0     0     3  0   2     0                             34      0   10    3     0     0     0  0   3     0                             93      3   10    7     4     0     2  0   8     0                             94      0   10    3     3     5     0  2   9     3                             102     0   10    3     3     0     0  0   7     2                             118     2   10    6     7     4     5  3   10    5                             119     7   10    6     7     3     3  3   10    7                             120     5   10    10    7     0     10 5   10    4                             130     0   10    4     7     5     3  5   10    3                             131     4   10    7     8     0     2  0   10    3                             132     4   10    7     7     10    4  0   10    4                             133     3   10    3     8     7     0  0   10    3                             134     7   10    7     9     --    3  3   10    5                             135     0   10    3     7     0     0  0   10    0                       (62 g/ha)                                                                             2      0   8     0     0     0     0  0   0     0                             25      0   10    7     0     0     0  0   6     0                             32      0   10    2     0     0     0  0   0     0                             34      0   10    3     0     0     0  0   0     0                             93      0   10    0     0     --    0  0   0     0                             94      0   7     0     0     3     0  0   6     0                             102     0   9     3     0     0     0  0   4     0                             118     0   10    5     2     4     0  3   10    0                             119     6   10    5     7     0     0  0   10    5                             120     2   10    7     6     0     2  5   10    3                             130     0   10    3     7     --    0  0   10    2                             131     3   10    5     8     0     0  0   9     0                             132     3   10    7     7     5     2  0   10    2                             133     3   7     0     7     6     0  0   9     2                             134     6   10    5     9     --    3  3   9     3                             135     0   10    0     6     0     0  0   8     0                       (31 g/ha)                                                                             2      0   3     0     0     0     0  0   0     0                             25      0   10    0     0     --    0  0   6     0                             94      0   5     0     0     0     0  0   5     0                             102     0   4     0     0     0     0  0   0     0                             118     0   10    4     0     0     0  0   8     0                             119     2   10    3     7     0     0  0   9     3                             120     0   10    4     6     0     0  4   9     0                             130     0   4     0     6     --    0  0   7     0                             131     0   10    4     7     0     0  0   8     0                             132     0   10    3     7     3     0  0   9     0                             133     2   5     0     6     3     0  0   7     0                             134     3   10    4     9     --    0  0   8     3                             135     0   7     0     5     0     0  6   0                             __________________________________________________________________________     Rate  COMPOUND                                                                               Giant foxtail                                                                         Green foxtail                                                                         Jimsonweed                                                                            Johnsongrass                                                                          Lambsquarters                                                                          Morningglory                                                                          Nutsedge              __________________________________________________________________________     (500 g/ha)                                                                           32      10     10     0      10     --      0      0                           34      10     10     0      10     --      0      0                           93      10     10     0      9      --      0      3                     (250 g/ha)                                                                            2      10     10     0      8      3       0      0                           25      10     9      6      10     10      10     0                           32      10     10     0      8      --      0      0                           34      10     10     0      7      --      0      0                           93      10     10     0      8      --      0      0                           94      10     9      3      6      --      4      5                           102     10     7      3      4      6       3      0                           118     10     10     0      10     10      --     4                           120     10     10     4      10     9       --     5                           130     10     10     5      9      9       --     4                           131     10     10     5      10     9       5      4                           132     10     10     5      10     9       3      4                           133     10     10     5      7      8       5      8                           134     10     10     6      8      10      5      5                           135     10     10     0      8      9       0      0                     (125 g/ha)                                                                            2      9      7      0      5      2       0      0                           25      10     6      3      7      3       6      0                           32      8      7      0      8      --      0      0                           34      10     10     0      7      --      0      0                           93      10     10     0      5      --      0      0                           94      10     6      0      5      --      4      3                           102     8      5      0      2      5       0      0                           118     10     10     0      10     3       --     3                           119     10     10     0      8      9       4      3                           120     10     10     3      10     9       --     5                           130     10     10     2      8      0       --     0                           131     10     10     5      10     8       3      4                           132     10     10     5      9      8       3      3                           133     10     9      4      5      8       3      3                           134     10     10     6      7      7       4      0                           135     10     10     0      7      7       0      0                     (62 g/ha)                                                                             2      7      5      0      2      0       0      --                          25      10     6      3      5      0       0      0                           32      7      7      0      2      8       0      0                           34      7      7      0      4      --      0      0                           93      2      2      0      0      --      0      0                           94      4      4      0      0      --      4      0                           102     7      5      0      0      3       0      0                           118     10     10     0      7      0       --     3                           119     9      10     0      7      9       4      3                           120     10     10     2      6      8       --     0                           130     10     10     2      3      0       --     0                           131     8      10     4      7      7       3      4                           132     10     10     5      7      7       3      0                           133     7      5      3      4      7       0      0                           134     9      10     5      7      7       3      0                           135     9      9      0      4      7       0      0                     (31 g/ha)                                                                             2      2      3      0      0      0       0      0                           25      9      6      3      5      0       0      0                           94      3      3      0      0      --      4      0                           102     5      4      0      0      3       0      0                           118     6      9      0      5      0       --     0                           119     8      9      0      4      9       3      0                           120     10     6      0      4      0       --     0                           130     2      2      0      0      0       --     0                           131     6      5      4      4      5       0      4                           132     7      8      5      7      7       3      0                           133     5      4      0      3      7       0      0                           134     8      5      4      5      5       0      0                           135     7      7      0      3      6       0      0                     __________________________________________________________________________                                                         Wild                       Rate  COMPOUND                                                                               Rape                                                                              Rice                                                                              Sicklepod                                                                            Soybean                                                                             Sugar beet                                                                           Teaweed                                                                             Velvetleaf                                                                           Wheat                                                                              buckwheat                                                                            Wild                 __________________________________________________________________________                                                               oat                  (500 g/ha)                                                                           32      3  0  0     0    0     3    6     0   0     4                          34      0  0  --    0    0     5    3     0   0     0                          93      0  3  --    0    5     6    4     8   8     6                    (250 g/ha)                                                                            2      2  0  0     0    0     0    3     0   0     0                          25      3  0  3     0    4     9    0     0   5     3                          32      2  0  0     0    0     2    5     0   0     2                          34      0  0  3     0    0     5    3     0   0     0                          93      0  -- 7     0    0     2    2     5   6     2                          94      0  6  3     0    0     7    8     3   0     4                          102     0  3  3     0    6     3    0     4   7     3                          118     2  3  9     7    9     6    9     2   9     6                          120     0  9  7     6    6     9    9     --  9     4                          130     0  0  5     3    5     8    9     4   10    2                          131     0  7  8     4    7     6    7     2   8     3                          132     0  6  7     3    8     7    7     4   10    4                          133     0  3  7     6    7     7    5     4   7     0                          134     2  3  7     6    9     5    7     6   7     6                          135     3  0  8     5    6     10   7     0   8     0                    (125 g/ha)                                                                            2      0  0  0     0    0     0    2     0   0     0                          25      0  0  0     0    3     5    0     0   0     0                          32      0  0  0     0    0     0    1     0   0     0                          34      0  0  0     0    0     2    0     0   0     0                          93      0  3  --    0    0     0    0     3   3     0                          94      0  0  0     0    0     6    3     2   0     3                          102     0  0  0     0    3     0    0     3   5     0                          118     0  2  5     5    7     --   8     0   9     0                          119     0  7  8     3    6     3    6     7   8     6                          120     0  -- 5     5    5     9    8     5   8     2                          130     0  0  5     0    4     6    5     4   9     0                          131     0  6  6     4    6     5    6     0   7     3                          132     0  5  6     0    6     7    7     3   8     3                          133     0  3  5     4    6     6    4     2   7     0                          134     0  0  7     5    7     3    6     4   7     4                          135     2  0  3     0    6     3    6     0   7     0                    (62 g/ha)                                                                             2      0  0  0     0    0     0    --    0   0     0                          25      0  0  0     0    0     5    0     0   0     0                          32      0  0  0     0    0     0    0     0   0     0                          34      0  0  0     0    0     2    0     0   0     0                          93      0  0  6     0    0     --   0     0   0     0                          94      0  0  0     0    0     6    0     0   0     0                          102     0  0  0     0    0     0    0     0   3     0                          118     0  0  2     0    4     --   8     0   5     0                          119     0  5  6     3    5     3    6     4   7     4                          120     0  8  3     3    5     8    7     3   8     0                          130     0  0  2     0    4     3    4     0   4     0                          131     0  0  5     3    5     4    0     0   7     0                          132     0  3  6     0    6     6    3     2   7     2                          133     0  2  5     3    5     4    3     0   5     0                          134     0  0  7     3    6     3    5     3   7     3                          135     0  0  0     0    4     3    4     0   5     0                    (31 g/ha)                                                                             2      0  0  0     0    0     0    0     0   0     0                          25      0  0  0     0    0     5    0     0   0     0                          94      0  0  0     0    0     6    0     0   0     0                          102     0  0  0     0    0     0    0     0   2     0                          118     0  0  2     0    2     5    2     0   --    0                          119     0  2  4     0    3     3    5     3   6     3                          120     0  0  3     0    4     6    3     0   6     0                          130     0  0  0     0    0     2    0     0   3     0                          131     0  0  5     0    4     3    0     0   6     0                          132     0  3  5     0    5     6    0     0   6     0                          133     0  0  0     2    4     0    2     0   5     0                          134     0  0  5     0    6     0    4     3   7     0                          135     0  0  0     0    4     0    3     0   3     0                    __________________________________________________________________________

TEST D

Compounds evaluated in this test were formulated in a non-phytotoxic solvent and applied to the soil surface before plant seedlings emerged (preemergence application), to water that covered the soil surface (paddy application), and to plants that were in the one-to-four leaf stage (postemergence application). A sandy loam soil was used for the preemergence and postemergence tests, while a silt loam soil was used in the paddy test. Water depth was approximately 2.5 cm for the paddy test and was maintained at this level for the duration of the test.

Plant species in the preemergence and postemergence tests consisted of barley (Hordeum vulgate), blackgrass (Alopecurus myosuroides), chickweed (Stellaria media), corn (Zea mays), cotton (Gossypium hirsutum), crabgrass (Digitaria sanguinalis), downy brome (Bromus tectorum), galium (Galium aparine), giant foxtail (Setaria faberii), lambsquarters (Chenopodium album), morningglory (Ipomoea hederacea), pigweed (Amaranthus retroflexus), rape (Brassica napus), ryegrass (Lolium multiflorum), sorghum (Sorghum bicolor), soybean (Glycine max), speedwell (Veronica persica), sugar beet (Beta fulgaris), velvetleaf (Abutilon theophrasti), wheat (Triticum aestivum), wild buckwheat (Polygonum convolvulus), and wild oat (Avena fatua). All plant species were planted one day before application of compounds for the preemergence portion of this test. Plantings of these species were adjusted to produce plants of appropriate size for the postemergence portion of the test. Plant species in the paddy test consisted of barnyardgrass (Echinochloa crus-galli), rice (Oryza sativa), and umbrella sedge (Cyperus difformis).

All plant species were grown using normal greenhouse practices. Visual evaluations of injury expressed on treated plants, when compared to untreated controls, were recorded approximately fourteen to twenty-one days after application of test compounds. Plant response ratings, summarized in Table D, were recorded on a 1 to 10 scale where 0 is no injury and 10 is plant death. A dash (-) response means no test result.

    TABLE D       POSTEMERGENCE         Downy  Giant        COMPOUND Rate Barley Blackgras      s Chickweed Corn Cotton Crabgrass brome Galium foxtail Lambsquarters      Morningglory Pigweed Rape Ryegrass Sorghum Soybean        136 (250 g/ha) 2 5 9 2 0 8 0 7 7 9 0 2 5 4 3 0 145  2 0 0 2 0 3 0 5 6      0 3 0 0 3 0 0 146  5 9 4 2 0 7 0 2 8 0 0 0 0 7 30 147  6 4 0 3 0 8 2 0 8      0 3 0 0 6 40 152  8 9 9 8 3 8 7 8 7 8 2 7 0 8 6 6 153  9 9 8 7 3 7 8 6 8      9 0 7 0 9 8 6 154  7 8 8 7 0 9 6 7 8 6 2 6 0 8 6 2 155  0 5 8 3 3 3 0 2      7 5 0 0 3 0 0 2 157  4 8 9 6 3 6 5 4 8 8 0 0 0 7 6 2 158  0 5 6 0 3 6 0      4 7 6 0 5 2 0 0 7        POSTEMERGENCE PADDY PREEMERGENCE    Sugar Velvet-  Wild Wild      Umbrella       Downy        COMPOUND Rate Speedwell beet leaf Wheat buckwheat oat Barnyardgrass      Rice sedge Barley Blackgrass Chickweed Corn Cotton Crabgrass brome        136 (250 g/ha) 9 8 5 3 9 0 9 8 9 3 8 7 4 0 10  3 145  0 8 5 3 9 0 9 7      4 3 10  7 3 3 9 3 146  0 0 2 4 6 0 8 7 8 2 10  7 2 2 10 3 147  0 0 4 6 0      3 8 7 8 4 10  8 3 3 10  0 152  9 10  6 8 10  8 10  9 10  5 10  9 5 5 10      5 153  10  10  7 -- 10  6 10  9 9 7 10  9 6 5 10 5 154  9 8 6 7 9 6 10      9 10  5 10  8 7 4 10  7 155  7 9 6 0 9 4 10  8 9 3 7 8 0 2 10  0 157  9      9 4 4 9 5 10  9 9 3 9 9 0 3 10  4 158  6 10  5 0 7 0 10  7 9 0 7 8 0 2      10        3                                                                      P      REEMERGENCE    Giant         Sugar Velvet-  Wild Wild COMPOUND Rate      Galium foxtail Lambsquarters Morningglory Pigweed Rape Ryegrass Sorghum      Soybean Speedwell beet leaf Wheat buckwheat oat        136 (250 g/ha) -- 10  9 0 7 5 7 5 3 -- 9 8 4 9 4 145  3 10  10  2 3 0      10  3 1 -- 0 5 3 5 0 146  0 10  10  0 0 0 10  4 0-- 0 5 3 5 0 147  0 10      -- 2 2 0 10  8 2 -- 0 7 4 4 3 152  -- 10  9 0 8 0 10  10  79 9 8 5 9 10      153  -- 10  9 0 8 6 10  10  8 8 8 8 5 9 10  154  -- 10  8 0 7 0 10  6 0      10  9 8 5 8 6 155  -- 10  9 0 7 4 3 4 0 7 8 8 0 7 -- 157  -- 10  9 0 7 3      7 6 0 8 8 7 4 8 0 158  6 10        8 0 7 3 5 3 0 7 7 8 0 6 0                     POSTEMERGENCE      Downy  Giant        COMPOUND Rate Barley Blackgrass Chickweed Corn      Cotton Crabgrass brome Galium foxtail Lambsquarters Morningglory Pigweed      Rape Ryegrass Sorghum Soybean        136 (125 g/ha) 0 4 9 0 0 6 0 4 5 6 0 2 5 0 2 0 145  0 0 0 0 0 0 0 0 5      0 0 0 0 0 0 0 146  2 2 0 0 0 3 0 0 4 0 0 0 0 5 0 0 147  5 -- 0 2 0 7 0 0      7 0 2 0 0 6 3 0 152  5 8 7 6 2 4 5 3 7 7 0 3 0 4 3 4 153  4 6 7 6 2 5 5      3 7 6 0 5 0 7 3 3 154  6 6 8 6 0 7 5 6 7 6 0 3 0 7 2 0 155  0 3 5 0 0 0      0 2 4 -- 0 0 0 0 0 0 157  4 7 7 6 0 3 4 3 7 7 0 0 0 4 0 0 158  0 0 2 0 2      4 0 0 7 5 0 5 0 0 0 3        POSTEMERGENCE PADDY PREEMERGENCE    Sugar Velvet-  Wild Wild      Umbrella       Downy        COMPOUND Rate Speedwell beet leaf Wheat buckwheat oat Barnyardgrass      Rice sedge Barley Blackgrass Chickweed Corn Cotton Crabgrass brome        136 (125 g/ha) 7 2 5 0 9 0 9 7 9 2 8 7 1 0 10  2 145  0 0 2 3 0 0 6 3      3 0 7 7 1 2 9 0 146  0 0 0 2 4 0 6 4 4 0 7 6 0 1 10  0 147  0 0 3 5 0 0      6 7 4 3 8 7 2 2 10  0 152  6 8 3 3 8 3 10  8 9 5 10  9 3 0 10  3 153  9      4 5 6 9 5 10  8 9 4 10  8 2 3 10  4 154  8 -- 5 6 6 3 10 9 9 3 7 8 3 3      10  4 155  7 6 5 0 3 0 10  5 8 0 6 8 0 0 10  0 157  9 6 0 4 5 3 10  8 9      2 8 8 0 2 10 3 158  4 0 3 0 0 0 10  2 8 0 4 8 0 0 10        0                    PREEMERGENCE    Giant         Sugar Velvet-  Wild W      ild COMPOUND Rate Galium foxtail Lambsquarters Morningglory Pigweed Rape      Ryegrass Sorghum Soybean Speedwell beet leaf Wheat buckwheat oat        136 (125 g/ha) -- 10  8 0 7 5 7 4 0 7 9 7 3 9 3 145  0 9 10  0 2 0 7 1      0 -- 5 30 3 0 146  0 10  10  0 0 0 5 2 0 -- 0 5 3 3 2 147  0 9 -- 2 0 0      10  1 0 -- 0 5 3 3 2 152  -- 10  9 0 7 0 5 10  48 8 7 4 8 3 153  -- 10      9 0 7 3 6 10  6 8 7 8 4 8 10  154  7 10  8 0 6 0 8 3 0 8 8 8 4 7 3 155      -- 10  9 0 6 3 0 3 0 7 6 6 3 7 0 157  0 10  8 0 3 0 5 3 0 7 6 6 0 4 0      158  0 10        8 0 6 2 0 0 0 6 6 6 0 4 0      POSTEMERGENCE         Downy  Giant        COMPOUND Rate Barley Blackgrass       Chickweed Corn Cotton Crabgrass brome Galium foxtail Lambsquarters      Morningglory Pigweed Rape Ryegrass Sorghum Soybean        136 (62 g/ha) 0 4 2 0 0 2 0 0 2 3 0 0 0 0 0 0 145  0 0 0 0 0 0 0 0 5 0      0 0 0 0 0 0 146  0 0 0 0 0 2 0 0 3 0 0 0 0 0 0 0 147  4 0 0 0 0 0 0 0 2      0 0 0 0 4 2 0 152  4 5 7 3 0 3 4 0 4 5 0 0 0 3 0 2 153  2 4 6 2 2 3 0 2      6 4 0 4 0 0 0 2 154  3 4 6 4 0 6 3 5 7 0 0 0 0 0 0 0 155  0 0 0 0 0 0 0      0 0 4 0 0 0 0 0 0 157  2 2 5 0 0 3 3 0 4 -- 0 0 0 4 0 0 158  0 0 0 0 2 2      0 -- 3 4 0 3 0 0 0 2        POSTEMERGENCE PADDY PREEMERGENCE    Sugar Velvet-  Wild Wild      Umbrella       Downy        COMPOUND Rate Speedwell beet leaf Wheat buckwheat oat Barnyardgrass      Rice sedge Barley Blackgrass Chickweed Corn Cotton Crabgrass brome        136 (62 g/ha) 0 0 2 0 4 0 9 4 9 0 7 5 0 0 10  0 145  0 0 0 0 0 0 4 1 2      0 3 6 0 0 9 0 146  0 0 0 0 0 0 5 1 2 0 3 6 0 0 9 0 147  0 0 0 3 0 0 4 3      2 0 6 7 0 0 10  0 152  6 0 3 3 -- 0 10  7 9 3 7 9 0 0 10  0 153  6 -- 4      4 9 2 10  8 9 3 7 8 0 0 10  3 154  8 5 3 5 6 2 10 8 9 2 6 7 0 2 10  3      155  4 2 3 0 0 0 10  3 7 0 4 7 0 0 10  0 157  8 3 0 1 4 0 9 6 9 0 6 7 0      0 93 158  0 0 0 0 0 0 10        0 8 0 0 7 0 0 9 0                                PREEMERGENCE    Giant              Sugar Velvet-  Wild Wild COMPOUND Rate Galium foxtail Lambsquarte      rs Morningglory Pigweed Rape Ryegrass Sorghum Soybean Speedwell beet      leaf Wheat buckwheat oat        136 (62 g/ha) 8 10  5 0 6 2 4 2 0 2 8 5 0 8 2 145  0 8 10  0 0 3 0 0      -- 3 2 0 3 0 146  0 8 10  0 0 0 0 0 0 -- 0 2 0 3 0 147  0 8 -- 0 0 0 7 0      0 -- 0 5 0 0 0 152  -- 10  7 0 6 0 4 6 2 8 7 5 3 7 0 153  0 10  9 0 6 0      6 3 3 8 6 6 3 7 0 154  3 10  8 0 5 0 5 2 0 7 6 7 3 6 0 155  0 10  7 0 3      0 0 0 0 6 6 3 0 4 0 157  0 10  8 0 0 0 3 0 0 6 6 4 0 4 0 158  0 10  5 0      4 0 0 0 0 5 5 3 0 3 0        POSTEMERGENCE         Downy  Giant        COMPOUND Rate Barley      Blackgrass Chickweed Corn Cotton Crabgrass brome Galium foxtail Lambsquar      ters Morningglory Pigweed Rape Ryegrass Sorghum Soybean        136 (31 g/ha) 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 145  0 0 0 0 0 0 0 0 0 0      0 0 0 0 0 0 146  0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 147  0 0 0 0 0 0 0 0 0      0 0 0 0 0 0 0 152  0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 153  0 0 2 0 0 2 0 0      4 3 0 3 0 0 0 0 154  3 0 3 2 0 3 2 0 4 0 0 0 0 0 0 0 155  0 0 0 0 0 0 0      0 0 4 0 0 0 0 0 0 157  0 -- 0 0 0 3 0 0 3 0 0 0 0 0 0 0 158  0 0 0 0 2 0      0 0 0 0 0 0 0 0 0 0        POSTEMERGENCE PADDY PREEMERGENCE    Sugar Velvet-  Wild Wild      Umbrella       Downy        COMPOUND Rate Speedwell beet leaf Wheat buckwheat oat Barnyardgrass      Rice sedge Barley Blackgrass Chickweed Corn Cotton Crabgrass brome        136 (31 g/ha) 0 0 2 0 0 0 6 2 7 0 5 4 0 0 8 0 145  0 0 0 0 0 0 3 0 0 0      0 3 0 0 7 0 146  0 0 0 0 0 0 4 1 0 0 0 5 0 0 9 0 147  0 0 0 2 0 0 3 1 0      0 3 7 0 0 9 0 152  0 -- 2 0 6 0 9 4 9 0 5 7 0 0 10  0 153  3 0 0 2 0 0 9      2 9 0 6 8 0 0 10  0 154  4 0 0 0 -- 0 10 4 -- 0 3 7 0 0 10  0 155  0 2 0      0 0 0 10  2 -- 0 3 5 0 0 7 0 157  0 0 0 0 0 0 9 2 -- 0 3 7 0 0 8 0 158      0 0 0 0 0 0 9 0 2 0 0 3 0 0 5 0        PREEMERGENCE    Giant         Sugar Velvet-  Wild Wild COMPOUND Rate      Galium foxtail Lambsquarters Morningglory Pigweed Rape Ryegrass Sorghum      Soybean Speedwell beet leaf Wheat buckwheat oat        136 (31 g/ha) 8 8 0 0 4 0 0 0 0 2 7 3 0 5 0 145  0 4 10  0 0 0 0 0 0      -- 0 2 0 0 0 146  0 6 10  0 0 0 0 0 0 -- 0 2 0 0 0 147  0 7 -- 0 0 0 0 0      0 -- 0 0 0 0 0 152  -- 10  -- 0 5 0 3 3 2 6 6 3 0 6 0 153  0 10  3 0 3 0      3 2 0 6 5 0 0 6 0 154  0 10  5 0 0 0 3 0 0 6 4 4 0 4 0 155  0 9 5 0 0 0      0 0 0 4 4 0 0 3 0 157  0 10  8 0 0 0 0 0 0 6 2 3 0 2 0 158  0 8 3 0 0 0      0 0 0 3 4 0 0 0 0        POSTEMERGENCE         Downy  Giant        COMPOUND Rate Barley      Blackgrass Chickweed Corn Cotton Crabgrass brome Galium foxtail Lambsquar      ters Morningglory Pigweed Rape Ryegrass Sorghum Soybean        145 (16 g/ha) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 146  0 0 0 0 0 0 0 0 0 0      0 0 0 0 0 0 147  0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 152  0 0 0 0 0 2 0 0 0      0 0 0 0 0 0 0 153  0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 154  2 0 0 0 0 0 0 0      0 0 0 0 0 0 0 0 155  0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 157  0 0 0 0 0 3 0      0 0 0 0 0 0 0 0 0 158  0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0        POSTEMERGENCE PADDY PREEMERGENCE    Sugar Velvet-  Wild Wild      Umbrella       Downy        COMPOUND Rate Speedwell beet leaf Wheat buckwheat oat Barnyardgrass      Rice sedge Barley Blackgrass Chickweed Corn Cotton Crabgrass brome        145 (16 g/ha) 0 0 0 0 0 00 0 0 0 0 3 0 0 4 0 146  0 0 0 0 0 0 2 0 0 0      0 3 0 0 7 0 147  0 0 0 0 0 0 3 1 0 0 0 4 0 0 5 0 152  0 0 0 0 0 0 9 2 --      0 3 -- 0 0 10  0 153  0 0 0 0 0 0 8 1 -- 0 3 6 0 0 8 0 154  2 0 0 0 5 0      8 2 -- 0 3 7 0 0 8 0 155  0 0 0 0 0 0 9 0 -- 0 0 3 0 0 8 0 157  0 -- 0 0      -- 0 8 0 -- 0 0 0 0 0 3 0 158  0 0 0 0 0 0 9 0 -- 0 0 0 0 0 4 0        PREEMERGENCE    Giant         Sugar Velvet-  Wild Wild COMPOUND Rate      Galium foxtail Lambsquarters Morningglory Pigweed Rape Ryegrass Sorghum      Soybean Speedwell beet leaf Wheat buckwheat oat        145 (16 g/ha) 0 2 10  0 0 0 0 0 0 -- 0 0 0 0 0 146  0 2 10  0 0 0 0 0      0 -- 0 2 0 0 0 147  0 2 -- 0 0 0 0 0 0 -- 0 0 0 0 0 152  -- 8 0 0 4 0 0      0 0 5 3 0 0 4 0 153  0 10  0 0 0 0 0  0 5 3 0 0 4 0 154  10  3 0 0 0 0 0      0 0 4 3 0 0 3 0 155  0 6 3 0 0 0 0 0 0 3 0 0 0 0 0 157  0 10  3 0 0 0 0      0 0 3 0 0 0 0 0 158  0 5 0 0 0 0 0 0 0 3 0 0 0 0 0

TEST E

Plastic pots were partially filled with silt loam soil. The soil was then saturated with water. Indica and/or Japonica rice (Oryza sativa) seedlings at the 2.0 to 2.5 lead stage; seeds of barnyardgrass (Echinochloa crus-galli), bulrush (Scirpus mucronatus), duck salad (Heteranthera limosa), and umbrella sedge (Cyperus difformis); and tubers of arrowhead (Sagittaria spp.) and waterchestnut (Eleocharis spp.) were planted into this soil. Several days after planting, water levels were raised to 3 cm above the soil surface and maintained at this level throughout the test. Chemical treatments were formulated in a non-phytotoxic solvent and applied directly tot he paddy water. Treated plants and untreated controls were maintained in a greenhouse for 21 days, after which all treated plants were compared to untreated controls and visually evaluated. Plant response ratings, summarized in Table E, are reported on a 0 to 10 scale where 0 is no effect and 10 is complete control. A dash (-) response means no test result.

                                      TABLE E                                      __________________________________________________________________________     PADDY                                                                                                                       Japonica                                                                            Umbrella                     COMPOUND                                                                               Rate  Arrowhead                                                                            Barnyardgrass                                                                          Bulrush                                                                             Duck salad                                                                           Indica rice                                                                          rice sedge                                                                               Waterchestnut           __________________________________________________________________________      5      (500 g/ha)                                                                            7    10       7   --     4     7   10   10                       8             8    10       9   --     3     7   10    9                      25             0    10       0   10     7     5   10    6                      26            --     8       7    9     0     0   10    0                      27            --     9       8   10     0     4   10    0                      28            --    10       7   10     4     7   10    0                      29            --    10       0   10     0     0   10    0                      30            --     9       0   10     0     0   10    0                      31            --    10       7   10     3     5   10    0                      32            --    10       8   10    --     5   10    5                      50            --    10       8   10     0     3   10    5                      51            --    10       4   10    --     0    8    0                      53            --    10       0   10     0     0    0    0                      54            --    10       6   10     5     4    7    0                      56            --    10       6   10     0     0   10    0                      58            --     6       0    0     0     0    0    0                      59            --    10       0    0     2     3    0    9                      107            5    10      --   10    --     5   10    7                      110            0     8      --   10    --     1   10    0                      118            8    10      --   10    --     9   10    6                      119            9    10      --   10    --     7   10    8                      130            9     9      --   10    --     8   10    8                      149            0     7      --    4    --     1    2    0                      150            0     6      --    7    --     3    8    3                      151            0     8      --    4    --     2    6    3                      __________________________________________________________________________                                                  Japonica                                                                            Umbrella                     COMPOUND                                                                               Rate  Arrowhead                                                                            Barnyardgrass                                                                          Bulrush                                                                             Duck salad                                                                           Indica rice                                                                          rice sedge                                                                               Waterchestnut           __________________________________________________________________________      5      (250 g/ha)                                                                           10     8       7   --     0     2   10    8                       8             0     9       9   --     0     0   10    9                      25             0    10       0   10     6     0   10    0                      26            --     6       0    7     0     0   10    0                      27            --     9       4   10     0     2   10    0                      28            --    10       0   10     0     4    9    0                      29            --     7       0   10     0     0   10    0                      30            --     8       0   10     0      0   8    0                      31            --    10       6   10     3     4   10    0                      32            --    10       6    8    --     4   10    0                      50            --    10       5   10     0     0   10    0                      51            --     9       0   10    --     0    7    0                      53            --     9       0    5     0     0    0    0                      54            --    10       4   10     3     3    7    0                      56            --    10       9   10     0     0   10    0                      58            --     6       0    0     0     0    0    0                      59            --     8       0    0     0     2    0    9                      93            --    10       5   --     5     5   --    6                      107            3     9      --   10    --     3   10    4                      110            0     7      --   10    --     0    8    0                      118            8    10      --   10    --     6   10    5                      119            8     9      --   10    --     6   10    7                      130            9    10      --   10    --     5   10    8                      149            0     3      --    1    --     1    1    0                      150            0     0      --    0    --     1    1    1                      151            0     4      --    0    --     1    0    3                      __________________________________________________________________________                                                  Japonica                                                                            Umbrella                     COMPOUND                                                                               Rate  Arrowhead                                                                            Barnyardgrass                                                                          Bulrush                                                                             Duck salad                                                                           Indica rice                                                                          rice sedge                                                                               Waterchestnut           __________________________________________________________________________      5      (125 g/ha)                                                                            0     6       6   --     0     0   10    0                       8             0     8       0   --     0     0   10    9                      25             0    10       0   10     2     0   10    0                      26            --     0       0    0     0     0    0    0                      27            --     6       0    7     0     0    9    0                      28            --     9       0   10     0     4    8    0                      29            --     7       0   10     0     0   10    0                      30            --     4       0    0     0     0    0    0                      31            --     8       0   10     0     0   10    0                      32            --    10       4    6    --     0   10    0                      50            --     9       0   10     0     0    6    0                      51            --     8       0    6    --     0    5    0                      53            --     8       0    0     0     0    0    0                      54            --    10       4   10     3     0    5    0                      56            --     8       0    6     0     0    0    0                      58            --     4       0     0    0     0    0    0                      59            --     7       0    0     0     0    0    0                      93            --    10       2   --     0     0   --    2                      107            0     5      --   10    --     2    8    2                      110            0     4      --   10    --     0    8    0                      118            7    10      --   10    --     4   10    2                      119            5    10      --   10    --     4   10    5                      130            4     8      --   10    --     4   10    5                      149            0     0      --    0    --     1    0    0                      150            0     0      --    0    --     0    0    0                      151            0     0      --    0    --     1    0    0                      __________________________________________________________________________                                                  Japonica                                                                            Umbrella                     COMPOUND                                                                               Rate  Arrowhead                                                                            Barnyardgrass                                                                          Bulrush                                                                             Duck salad                                                                           Indica rice                                                                          rice sedge                                                                               Waterchestnut           __________________________________________________________________________      5      (64 g/ha)                                                                             0     4       0   --     0     0    9    0                       8             0     5       0   --     0     0   10    0                      25             0    10       0    8     0     0   10    0                      26            --     0       0    0     0     0    0    0                      27            --     5       0    8     0     0    9    0                      28            --     9       0   10     0     0    0    0                      29            --     6       0   10     0     0   10    0                      30            --     4       0    0     0     0    0    0                      31            --     7       0   10     0     0   10    0                      32            --    10       0    6    --     0    4    0                      50            --     8       0    5     0     0    6    0                      51            --     8       0    0    --     0    0    0                      53            --     7       0    0     0     0    0    0                      54            --     9       0   10     0     0    4    0                      56            --     7       0    0     0     0    0    0                      58            --     0       0    0     0     0    0    0                      59            --     7       0    0     0     0    0    0                      93            --    10       2   --     0     0   --    2                      107            0     4      --   10    --     0    4    2                      110            0     2      --    9    --     0    6    0                      118            6     7      --   10    --     3   10    0                      119            2     7      --   10    --     3   10    5                      130             2    7      --   10    --     1   10    2                      149            0     0      --    0    --     0    0    0                      150            0     0      --    0    --     0    0    0                      151            0     0      --    0    --     0    0    0                      __________________________________________________________________________                                                  Japonica                                                                            Umbrella                     COMPOUND                                                                               Rate  Arrowhead                                                                            Barnyardgrass                                                                          Bulrush                                                                             Duck salad                                                                           Indica rice                                                                          rice sedge                                                                               Waterchestnut           __________________________________________________________________________      5      (32 g/ha)                                                                             0     0       0   --     0     0    5    0                       8             0     0       0   --     0     0    5    0                      25             0    10       0    5     0     0    8    0                      26            --     0       0    0     0     0    0    0                      27            --     4       0    0     0     0    0    0                      28            --     8       0    8     0     0    0    0                      29            --     3       0   10     0     0   10    0                      30            --     0       0    0     0     0    0    0                      31            --     6       0    9     0     0    8    0                      32            --    10       0    0    --     0    0    0                      50            --     7       0    0     0     0    0    0                      51            --     6       0    0    --     0    0    0                      53            --     7       0    0     0     0    0    0                      54            --     9       0    0     0     0    0    0                      56            --     6       0    0     0     0    0    0                      58            --     0       0    0     0     0    0    0                      59            --     5       0    0     0     0    0    0                      93            --     7       2   --     0     0   --    2                      107            0     0      --   10    --     0    0    2                      110            0     0      --    9    --     0    2    0                      118            2     6      --   10    --     2   10    0                      119            0     4      --    9    --     2    9    4                      130            0     5      --   10    --     0   10    2                      149            0     0      --    0    --     0    0    0                      150            0     0      --    0    --     0    0    0                      151            0     0      --    0    --     0    0    0                      __________________________________________________________________________                    COMPOUND                                                                               Rate  Barnyardgrass                                                                          Bulrush                                                                             Indica rice                                                                          Japonica                                                                              Waterchestnut           __________________________________________________________________________                    93      (16 g/ha)                                                                             4       2    0     0      0                      __________________________________________________________________________

TEST F

Seeds of spring and winter barley (Hordeum vulgare), blackgrass (Alopecurus myosuroides), black nightshade (Solanum nigrum), bluegrass (Poa annua), cheatgrass (Bromus secalinus), downy brome (Bromus tectorum), field pennycress (Thlaspi arvense), field violet (Viola arvensis), galium (Galium aparine), green foxtail (Setaria viridis), ivyleaf speedwell (Veronica hederaefolia), jointed goatgrass (Aegilops cylindrica), kochia (Kochia scoparia), lambsquarters (Chenopodium album), persian speedwell (Veronica persica), rape (Brassica napus), Russian thistle (Salsola kali), ryegrass (Lolium multiflorum), scentless chamomile (Matricaria inodora), sugar beet (Beta vulgaris), spring and winter wheat (Triticum aestivum), wild buckwheat (Polygonum convolvulus) and wild oat (Avena fatua) were planted and treated preemergence with the test chemical dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were also treated with postemergence applications of the test chemical. Plants ranged in height from two to twenty-four cm for postemergence treatments. Blackgrass and wild oat were treated postemergence at two growth stages. The first growth stage (1 ) was at the 1-2 leaf stage while the second stage (2) was at the four leaf stage. Treated plants and untreated controls were maintained in a greenhouse for approximately 21 days. All treated plants were then compared to untreated controls and visually evaluated for injury. Plant response ratings, summarized in Table F, are based on a zero to ten scale where 0 is no effect and 10 is complete control.

                                      TABLE F                                      __________________________________________________________________________     POSTEMERGENCE                                                                  COMPOUND 25                                                                             Rate (500 g/ha)                                                                        Rate (250 g/ha)                                                                        Rate (125 g/ha)                                                                        Rate (64 g/ha)                                                                         Rate (32 g/ha)                        __________________________________________________________________________     Barley (Spring)                                                                         5       4       4       2       1                                     Barley (Winter)                                                                         5       4       2       1       0                                     Blackgrass (1)                                                                          3       1       0       0       0                                     Blackgrass (2)                                                                          2       0       0       0       0                                     Blk. nightshade                                                                         0       0       0       0       0                                     Bluegrass                                                                               2       1       0       0       0                                     Cheatgrass                                                                              0       0       0       0       0                                     Downy brome                                                                             0       0       0       0       0                                     Fld. pennycress                                                                         0       0       0       0       0                                     Fld. violet                                                                             2       0       0       0       0                                     Galium   0       0       0       0       0                                     Green foxtail                                                                           4       2       1       0       0                                     Ivylf speedwell                                                                         0       0       0       0       0                                     Jntd. goatgrass                                                                         1       0       0       0       0                                     Kochia   2       0       0       0       0                                     Lambsquarters                                                                           4       3       0       0       0                                     Prsn. speedwell                                                                         0       0       0       0       0                                     Rape     4       2       1       0       0                                     Russian thistle                                                                         1       0       0       0       0                                     Ryegrass 3       1       0       0       0                                     Snls. chamomile                                                                         0       0       0       0       0                                     Sugar beet                                                                              2       1       1       0       0                                     Wheat (Spring)                                                                          7       4       2       1       0                                     Wheat (Winter)                                                                          2       2       1       0       0                                     Wild buckwheat                                                                          0       0       0       0       0                                     Wild oat (1)                                                                            1       0       0       0       0                                     Wild oat (2)                                                                            1       0       0       0       0                                     __________________________________________________________________________     PREEMERGENCE                                                                   COMPOUND 25                                                                             Rate (500 g/ha)                                                                        Rate (250 g/ha)                                                                        Rate (125 g/ha)                                                                        Rate (64 g/ha)                                                                         Rate (32 g/ha)                        __________________________________________________________________________     Barley (Spring)                                                                         6       3       2       1       1                                     Barley (Winter)                                                                         4       2       1       0       0                                     Blackgrass                                                                              6       3       2       0       0                                     Blk. nightshade                                                                         0       0       0       0       0                                     Bluegrass                                                                               8       8       7       5       2                                     Cheatgrass                                                                              6       6       5       3       0                                     Downy brome                                                                             3       1       0       0       0                                     Fld. pennycress                                                                         10      7       4       0       0                                     Fld. violet                                                                             2       0       0       0       0                                     Galium   5       0       0       0       0                                     Green foxtail                                                                           10      10      10      8       3                                     Ivylf speedwell                                                                         2       0       0       0       0                                     Jntd. goatgrass                                                                         3       1       0       0       0                                     Kochia   3       1       0       0       0                                     Lambsquarters                                                                           2       1       1       0       0                                     Prsn. speedwell                                                                         7       7       2       0       0                                     Rape     3       3       2       0       0                                     Russian thistle                                                                         3       1       0       0       0                                     Ryegrass 9       9       9       7       4                                     Snls. chamomile                                                                         7       2       0       0       0                                     Sugar beet                                                                              5       3       3       2       2                                     Wheat (Spring)                                                                          3       1       1       0       0                                     Wheat (Winter)                                                                          2       1       0       0       0                                     Wild buckwheat                                                                          2       0       0       0       0                                     Wild oat 2       1       0       0       0                                     __________________________________________________________________________

TEST G

Seeds, rhizomes, or tubers of alfalfa (Medicago sativa), barnyardgrass (Echinochloa crus-galli), bermudagrass (Cynodon dactylon), broadleaf signalgrass (Brachiaria plantaginea), field bindweed (Convolvulus arvensis), guineagrass (Panicum maximum), johnsongrass (Sorghum halepense), large crabgrass (Digitaria sanguinalis), pitted morningglory (Ipomoea lacunosa), purple nutsedge (Cyperus rotundus), purslane (Portulaca oleracea), ragweed (Ambrosia artemisiifolia), sandbar (Cenchrus echinatus), smooth crabgrass (Digitaria ischaemum), Texas panicum (Panicum texanum), tropical kudzu (Pueraria javanica), and yellow nutsedge (Cyperus esculentus) were planted into greenhouse pots containing greenhouse planting medium. Each pot contained only one plant species. Test compounds were dissolved in a non-phytotoxic solvent and applied to the soil surface (preemergence). These applications were made within one day of planting. Control pots receiving not test treatments and treated pots were maintained under greenhouse conditions for 13 to 21 days after herbicide application. Growth of treated plants was compared to that of untreated controls and visually evaluated. Plant response ratings, summarized in Table G, are based on a zero to 10 scale where zero is no injury, and 10 is plant death. A dash (-) response means no test result.

                  TABLE G                                                          ______________________________________                                         PREEMERGENCE                                                                             COMPOUND                                                                       118  132    136    147  153  154  157                                ______________________________________                                         Rate (250 g/ha)                                                                Alfalfa     2      5      3    0    2    4    3                                Barnyardgrass                                                                              10     10     10   10   10   10   10                               Bermudagrass                                                                               10     10     10   10   10   10   10                               Brdlf sgnlgrass                                                                            10     10     10   10   10   10   10                               Field bindweed                                                                             0      5      1    0    1    1    0                                Guineagrass 10     10     9    10   10   10   10                               Johnsongrass                                                                               8      10     2    2    10   10   10                               Large crabgrass                                                                            9      10     10   10   10   10   10                               Pitted mrnglory                                                                            0      3      2    1    0    3    2                                Purple nutsedge                                                                            10     10     10   7    10   3    8                                Purslane    7      10     8    1    9    9    7                                Ragweed     1      6      2    0    5    10   9                                Sandbur     --     10     --   --   --   --   --                               Smooth crbgrass                                                                            10     10     10   10   10   10   10                               Texas panicum                                                                              6      10     5    9    10   10   9                                Trop. kudzu 6      10     9    7    9    9    9                                Yellow nutsedge                                                                            6      10     2    0    8    2    1                                Rate (125 g/ha)                                                                Alfalfa     0      3       1   0    1    4    5                                Barnyardgrass                                                                              10     10     10   10   10   10   10                               Bermudagrass                                                                               10     10     10   10   10   10   10                               Brdlf sgnlgrass                                                                            10     10     10   7    10   10   9                                Field bindweed                                                                             0      0      1    0    1    1    0                                Guineagrass 10     8      9    8    10   10   10                               Johnsongrass                                                                               4      10     2    0    9    9    10                               Large crabgrass                                                                            9      10     10   10   10   10   9                                Pitted mrnglory                                                                            1      0      1    0    1    3    2                                Purple nutsedge                                                                            10     8      10   0    7    1    3                                Purslane    5      7      3    0    10   6    2                                Ragweed     0      3      0    0    1    9    9                                Sandbur     --     10     --   --   --   --   --                               Smooth crbgrass                                                                            10     10     10   10   10   10   10                               Texas panicum                                                                              1      9      2    8    10   9    8                                Trop. kudzu 5      6      10   0    9    9    9                                Yellow nutsedge                                                                            1      4      0    0    1    1    0                                Rate (64 g/ha)                                                                 Alfalfa     0      3      1    0    0    2    1                                Barnyardgrass                                                                              10     10     8    0    10   10   10                               Bermudagrass                                                                               9      10     1    10   10   10   10                               Brdlf sgnlgrass                                                                            2      10     4    2    9    10   9                                Field bindweed                                                                             0      2      0    0    2    1    0                                Guineagrass 9      9      10   1    9    9    10                               Johnsongrass                                                                               1      3      0    0    10   6    8                                Large crabgrass                                                                            3      10     4    3    10   10   9                                Pitted mrnglory                                                                            0      0      0    0    1    1    2                                Purple nutsedge                                                                            10     10     10   0    1    0    1                                Purslane    3      2      2    0    2    6    1                                Ragweed     0      0      0    0    --   8    6                                Sandbur     --     10     --   --   --   --   --                               Smooth crbgrass                                                                            10     10     10   9    10   10   9                                Texas panicum                                                                              0      3      1    1    8    8    6                                Trop. kudzu 0      4      0    0    9    9    9                                Yellow nutsedge                                                                            0      3      0    0    1    0    0                                Rate (32 g/ha)                                                                 Alfalfa     0      2      0    0    1    0    1                                Barnyardgrass                                                                              0      10     7    0    10   10   10                               Bermudagrass                                                                               2      9      9    10   10   10   9                                Brdlf sgnlgrass                                                                            0      10     0    0    9    9    7                                Field bindweed                                                                             0      0      0    0    1    0    0                                Guineagrass 0      9      1    0    9    9    4                                Johnsongrass                                                                               0      2      0    0    3    2    1                                Large crabgrass                                                                            1      6      0    0    9    8    7                                Pitted mrnglory                                                                            0      0      0    0    0    1    2                                Purple nutsedge                                                                            1      0      0    --   1    0    0                                Purslane    0      0      0    0    1    2    0                                Ragweed     0      --     0    0    7    2    6                                Sandbur     --     10     --   --   --   --   --                               Smooth crbgrass                                                                            3      10     7    2    9    8    7                                Texas panicum                                                                              0      3      1    0    6    7    7                                Trop. kudzu 0      0      0    0    6    8    9                                Yellow nutsedge                                                                            0      2      0    0    1    0    0                                ______________________________________                                     

What is claimed is:
 1. The compounds of the formula ##STR35## and stereoisomers thereof, whereinX and Y are independently H or C(R³)(R⁴) OR⁵ ; R¹ is H or a straight-chain C₁ -C₃ alkyl; R² is H, C₁ -C₆ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, phenyl or C₁ -C₄ alkyl substituted by Ph, OH, CN, OR⁸, SO₂ R⁸, PhSO₂, N₃, CO₂ R⁸ or CO₂ H; R³, R⁴, R⁹ and R¹⁰ are independently H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl or C₁ -C₃ alkyl substituted with OCH₃ or OCH₂ CH₃ ; R⁵ is C₁ -C₃ alkyl, C₂ -C₄ alkenyl, C₃ -C₄ alkynyl, benzyl or C₁ -C₄ alkyl substituted with OR⁸, OCF₃ ; R⁸ is C₁ -C₃ alkyl; Q is WCH₂ or ##STR36## W is phenyl optionally substituted with 1-3 substituents selected from F. Cl, Br, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, OH, CN, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy, C₁ -C₃ alkylthio, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl, or W is a 5 or 6-membered heterocyclic ring containing 0-2 nitrogens, 0-2 oxygens of 0-2 sulfurs, each ring optionally substituted with 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃ ; Z¹ is CH₂, NR_(a), O, S or may be taken to form a double bond with an adjacent carbon; R_(a) is H or C₁ -C₃ alkyl; R⁶ is H, halogen, R⁸, OR⁸, SR⁸ or CN; R⁷ is H, F, Cl, CH₃, OCH₃, OH or OR⁸ ; q¹ is 0, 1 or 2; and q is 0, 1 or 2.provided that 1) at least one of X and Y is C(R³)(R⁴)OR⁵ ; 2) R³, R⁴, R⁹ and R¹⁰ each contains no more than four carbon atoms; 3) the sum of q and q¹ is 0, 1 or 2; and 4) if the sum of q and q¹ is 0 then Z¹ is CH₂.
 2. The compounds of Formula III according to claim 1 wherein:W is phenyl optionally substituted by 1-2 substituents selected from F, Cl, Br, CH₃ and OCH₃ ; or W is tetrahydropyran, tetrahydrofuran, thiophene, isoxazole, pyridine or pyrazine, each ring optionally substituted with 1-2 substituents selected from F, Cl, Br, CH₃ or OCH₃ ; Q is ##STR37## R_(a) is H or C₁ -C₃ alkyl; and R⁵ is other than benzyl.
 3. The compounds of claim 3 whereinR³ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;
 4. The compounds of claim 3 whereinR³ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl; R⁴ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl; R⁵ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl; R⁹ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl; R¹⁰ is H, C₁ -C₃ alkyl, C₃ -C₄ alkenyl or C₃ -C₄ alkynyl;
 5. The compounds of claim 4 wherein Q is Q-1, Q-3, Q-6, Q-7 or Q-15.
 6. The compound of claim 4 which is: 2-(ethoxymethyl)-5-methyl-4-(phenylmethoxy)-6-oxabicyclo[3.2.1]octane, (2-endo, 4-endo).
 7. The compound of claim 4 which is 5-ethyl-4-(2,6-difluorophenylmethoxy)-2-methoxymethyl-6-oxabicyclo [3.2.1]octane, (2-endo, 4-endo).
 8. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 1 and at least one of the following: surfactant, solid or liquid diluent.
 9. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 2 and at least one of the following: surfactant, solid or liquid diluent.
 10. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 3 and at least one of the following: surfactant, solid or liquid diluent.
 11. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 4 and at least one of the following: surfactant, solid or liquid diluent.
 12. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 5 and at least one of the following: surfactant, solid or liquid diluent.
 13. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 6 and at least one of the following: surfactant, solid or liquid diluent.
 14. An agriculturally suitable composition for controlling the growth of undesired vegetation comprising an effective amount of the compound of claim 7 and at least one of the following: surfactant, solid or liquid diluent.
 15. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 1. 16. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 2. 17. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 3. 18. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 4. 19. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 5. 20. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 15. 21. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 7. 